Sentences with phrase «nucleotide polymorphisms from»

To find out, Craig and his colleagues developed a mathematical strategy to search the pool for DNA variants called single - nucleotide polymorphisms from a known individual.

Not exact matches

One of the tools, the SNP - Seek database, is designed to provide user - friendly access to a type of genetic marker called single nucleotide polymorphisms (SNPs) identified from this data.

The lab has also shifted from testing genetic markers known as short tandem repeats (STRs), which are standard in paternity testing, to recording single letter variants in the genetic code known as single nucleotide polymorphisms, or SNPs, which are rarely used for this purpose.

Results from a statistical analysis shows a cluster of SNPs — single nucleotide polymorphisms — in one section of a single gene, indicating the location of a mutation likely linked to autism.

The researchers looked at functional single nucleotide polymorphisms within the CLOCK gene that are able to influence how much protein is transcribed from the gene.

From beetles collected at 27 sites in Alberta and British Columbia, they looked for any patterns amongst their catalog of 1536 mutations (single - nucleotide polymorphisms, or SNPs).

To get a clearer picture of the settlement patterns, David Reich of Harvard Medical School in Boston and his colleagues compared DNA from 52 Native American populations across Canada, Greenland and Central and Southern America, focusing on variations called single - nucleotide polymorphisms (SNPs) in protein - coding and non-coding regions across the genome.

To identify new genetic variations associated with different SLE phenotypes, a total of 598,258 different regions on the genome (known as single - nucleotide polymorphisms) were genotyped in a population of 482 Caucasian European SLE patients of Spanish origin recruited from the rheumatology departments of 15 Spanish university hospitals belonging to the IMID Consortium (SLE group).

Then they checked blood samples against half a million known variations in DNA sequences, or single - nucleotide polymorphisms, which recently were identified by the International HapMap Project that looked for differences in the genomes of people from many populations.

The team identified 15 new genetic CAD associations, via SNPs — or single - nucleotide polymorphisms, places in genes in which the DNA building blocks differ from person to person by only one block, or nucleotide.

Objective To identify common genetic markers that may confer differential benefit from aspirin or NSAID chemoprevention, we tested gene × environment interactions between regular use of aspirin and / or NSAIDs and single - nucleotide polymorphisms (SNPs) in relation to risk of colorectal cancer.

Previous genetic studies have examined the association of aspirin, NSAIDs, or both with colorectal cancer according to a limited number of candidate genes or pathways.6 - 10 Thus, to comprehensively identify common genetic markers that characterize individuals who may obtain differential benefit from aspirin and NSAIDs, we conducted a discovery - based, genome - wide analysis of gene × environment interactions between regular use of aspirin, NSAIDs, or both and single - nucleotide polymorphisms (SNPs) in relation to risk of colorectal cancer.

Estimation of population parameters and recombination rates from single nucleotide polymorphisms.

Estimating population divergence time and phylogeny from single ‐ nucleotide polymorphisms data with outgroup ascertainment bias.

Estimating population divergence time and phylogeny from single ‐ nucleotide polymorphisms data with outgroup ascertainment bias Wang, Y. and R. Nielsen.

Estimation of population parameters and recombination rates from single nucleotide polymorphisms Nielsen, R. 2000.

Here we report a public database of common variation in the human genome: more than one million single nucleotide polymorphisms (SNPs) for which accurate and complete genotypes have been obtained in 269 DNA samples from four populations, including ten 500 - kilobase regions in which essentially all information about common DNA variation has been extracted.

We will then validate the generalizability of protective human immune responses against Clone 10 and other candidate antigens in an independent cohort of Tanzanian children, and investigate potential single nucleotide polymorphisms in Clone 10 from P. falciparumfield isolates from Tanzania.

In a new study, Sklar and her colleagues are scanning 500,000 gene variants, known as single nucleotide polymorphisms, obtained from a sampling of patients with bipolar disorder.

To date, this collaboration has built a catalogue of 1 million single nucleotide polymorphisms (SNPs) in more than 6,000 falciparum samples collected directly from malaria patients in Africa, Asia, Latin America and Oceania.

In this project, I applied NASP for single nucleotide polymorphism (SNP) identification and characterization, and used FigTree and PHYLOBar for phylogenetic analysis and visualization.The NASP method differs from other published SNP pipelines in terms of supported short - read aligners and SNP callers, the ability to call both monomorphic and polymorphic sites, and the ability to integrate the results from multiple SNP callers and identify the consensus set of SNPs that define the population structure.

Replication in 63,475 (47,227 of European ancestry) individuals from 33 cohorts for whole body lean body mass and in 45,090 (42,360 of European ancestry) subjects from 25 cohorts for appendicular lean body mass was successful for five single - nucleotide polymorphisms in / near HSD17B11, VCAN, ADAMTSL3, IRS1, and FTO for total lean body mass and for three single - nucleotide polymorphisms in / near VCAN, ADAMTSL3, and IRS1 for appendicular lean body mass.

Microsatellite genotypes were obtained for 203 clinical infection samples from eight locations, and Illumina paired - end sequences were obtained to yield high coverage genome - wide single nucleotide polymorphism (SNP) data for 65 clinical infection samples from four locations.

Additionally, copy number aberrations inferred from the Ion Torrent sequencing were compared to single nucleotide polymorphism arrays and found to be 59 % concordant on average.

To this end, we determined the susceptibility of 38 NAPCR1 isolates to ten antibiotics from seven classes using E-tests or macrodilution tests and examined 31 NAPCR1 whole - genome sequences to identify single nucleotide polymorphisms and genes that could explain the observed resistance phenotypes.

Methods: Here we genotype 276 single nucleotide polymorphisms (SNPs) in 5199 P. falciparum isolates from two Kenyan sites and one Gambian site to determine the spatio - temporal extent of parasite mixing, and use Principal Component Analysis (PCA) and linear regression to examine the relationship between genetic relatedness and relatedness in space and time for parasite pairs.

Genome sequence analysis was performed on multiple culture time point samples from six monoclonal isolates, and single nucleotide polymorphism (SNP) variants emerging over time were detected.

We are able to call 22 million high quality single nucleotide polymorphisms (SNP) from the nuclear genome, representing the largest SNP call set from an East Asian population to date.

Genome - based comparison of E. coli from infected patients and their immediate environment indicated low genetic similarity overall between the two, although three clinical - environmental isolate pairs differed by ≤ 5 single nucleotide polymorphisms.

One of the tools, the SNP - Seek database, is designed to provide user - friendly access to a type of genetic marker called single nucleotide polymorphisms (SNPs) identified from this data.

A previous method, COIL, was developed to estimate complexity of infection (COI) from single nucleotide polymorphism (SNP) data, but relies on monogenomic infections to estimate allele frequencies or requires external allele frequency data which may not available.

To gain a deeper understanding of how mosquito populations are evolving, here we sequenced the genomes of 765 specimens of Anopheles gambiae and Anopheles coluzzii sampled from 15 locations across Africa, and identified over 50 million single nucleotide polymorphisms within the accessible genome.

Methods: We did a genome - wide association study of 297 P falciparum isolates from Cambodia to investigate the relationship of 11 630 exonic single - nucleotide polymorphisms (SNPs) and 43 copy number variations (CNVs) with in - vitro piperaquine 50 % inhibitory concentrations (IC ₅₀ s), and tested whether these genetic variants are markers of treatment failure with dihydroartemisinin - piperaquine.

I've just returned from a four day conference taught by methylation expert Dr. Ben Lynch on SNPs (single nucleotide polymorphisms).

The information imparted here — including lists of toxic medications electromagnetic fields (EMFs), cancer screening, and SNPs (single nucleotide polymorphism — a type of genetic variation passed from parent to child which has become a critical component of personalized medicine) is a vital clarion call to us all.

Scientists used gene chips containing feline single nucleotide polymorphisms (SNPs)-- variations from the common feline DNA sequence that can help track down genes responsible for genetic diseases — to conduct their investigations.

They first looked for individual letters in DNA, called bases, that varied from one genome to the next, identifying about 4 million of these so - called single - nucleotide polymorphisms (SNPs).

Participants volunteered either a blood or saliva sample from which levels of serum serotonin (N = 66) and / or serotonin - system single nucleotide polymorphisms (N = 157) were assayed.