To gain a deeper understanding of how mosquito populations are evolving, here we sequenced the genomes of 765 specimens of Anopheles gambiae and Anopheles coluzzii sampled from 15 locations across Africa, and identified over 50 million single
nucleotide polymorphisms within the accessible genome.
The researchers looked at functional single
nucleotide polymorphisms within the CLOCK gene that are able to influence how much protein is transcribed from the gene.
Not exact matches
They reveal 341 fixed substitutions (35 nonsynonymous, 173 synonymous, and 133 noncoding) between the 2014 EBOV and all previously published EBOV sequences, with an additional 55 single -
nucleotide polymorphisms (SNPs; 15 nonsynonymous, 25 synonymous, and 15 noncoding), fixed
within individual patients,
within the West African outbreak.
The goal of this project is to identify the specific
nucleotide sequences and / or single
nucleotide polymorphisms that are correlated with expression of virulence and disease via comparative genomic analysis between B. pseudomallei strains as well as between various bacteriophages harbored
within B. pseudomallei.
The researchers zeroed in on a single -
nucleotide polymorphism (SNP) that appeared to be the causal mutation, typically consisting of an adenine
nucleotide but appearing as a guanine
nucleotide in roughly a third of the population, located in a region of noncoding DNA that falls
within the PHACTR1 gene.
To explore the possibility of common genetic pathways
within the respective pathophysiologies, nine ADHD candidate single
nucleotide polymorphisms (SNPs) in seven genes were tested for association with PD in 5333 cases and 12,019 healthy controls: one variant, respectively, in the genes coding for synaptosomal - associated protein 25 k (SNAP25), the dopamine (DA) transporter (SLC6A3; DAT1), DA receptor D4 (DRD4), serotonin receptor 1B (HTR1B), tryptophan hydroxylase 2 (TPH2), the norepinephrine transporter SLC6A2 and three SNPs in cadherin 13 (CDH13).
Whole genome association analysis studies that utilize single
nucleotide polymorphism (SNP) markers have been used to identify the molecular causes of various traits and conditions including genetic mutations
within breeds that cause coat color variations [15], hairlessness [25] and defects in spinal development [26].