Sentences with phrase «nucleotide resolution»

There she developed an approach, native elongation transcript sequencing, NET - seq, that directly visualizes global transcriptional activity through mapping RNA polymerase density genome - wide with single - nucleotide resolution.

Dynamic repertoire of a eukaryotic transcriptome surveyed at single - nucleotide resolution.

Luscombe, J. Ule (2010) iCLIP reveals the function of hnRNP particles in splicing at individual nucleotide resolution.

Recent computational improvements in analyses of HITS - CLIP maps have allowed robust genome - wide predictions of combinatorial RNA regulation and single - nucleotide resolution of protein interaction sites in the brain.

Using cutting - edge techniques enabled by next - generation sequencing, the authors generated complete methylome maps at single nucleotide resolution in a low - passage breast cancer cell line and normal breast tissue (primary human mammary epithelial cells).

Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution Nature, 461 (7265), 809 - 813 DOI: 10.1038 / nature08489

The excision products (26 — 34 nucleotides in length) were visualised at nucleotide resolution on a denaturing polyacrylamide gel as indicated.

Called individual nucleotide resolution crosslinking immunoprecipitation (iCLIP), the technique enabled Sanford's lab to identify IGF2BP3 binding sites in several hundred RNA transcripts in two B - ALL cell lines.

Not exact matches

That sort of resolution should be good enough to determine the sequence of all the nucleotide bases in the human genetic code.

We have determined at 2.1 angstrom resolution the crystal structure of a T7 RNAP elongation complex with 30 base pairs of duplex DNA containing a «transcription bubble» interacting with a 17 - nucleotide RNA transcript.

Whole - genome sequencing (WGS) marks the final step in increasing genetic marker density by assaying all single - nucleotide variants (SNVs), and thus has the potential to further improve relationship detection by enabling more accurate detection of IBD segments and more precise resolution of IBD segment boundaries.

However, the NextSeq series ™ NGS generates genome - wide sequence data as «digital data» in the resolution of single nucleotide and has no specificity, discrimination and sensitivity issues.

At the highest level of resolution, the user can inspect the nucleotide sequence of individual genes.