Microspheres are then able to use proteinoids as templates to make polynucleotides, which are themselves nonrandom because specific three -
nucleotide sequences bind preferentially to specific amino acids.
Cloning and
sequencing of complementary DNA's from normal and WHHL rabbits, shows that this defect arises from an in - frame deletion of 12
nucleotides that eliminates four amino acids from the cysteine - rich ligand
binding domain of the LDL receptor.