The DNA in
the nucleus of the fertilized egg contains all the instructions needed to make all the different proteins and all the different sorts of structures in all the different sorts of cells in the body.
Not exact matches
The method, called somatic cell nuclear transfer (SCNT), replaces the DNA in an
egg cell's
nucleus with the genetic material from the
nucleus of a skin cell, then tricks the
egg cell to start dividing as if it had been
fertilized with sperm.
But like the medieval alchemists, today's cloning and stem cell biologists are working largely with processes they don't fully understand: What actually happens inside the oocyte to reprogram the
nucleus is still a mystery, and scientists have a lot to learn before they can direct a cell's differentiation as smoothly as nature's program
of development does every time
fertilized egg gives rise to the multiple cell types that make up a live baby.
Cytoplasmic transfer involves injecting a bit
of cytoplasm — the jellylike substance that surrounds the
nucleus of an
egg — from a healthy donor
egg into the
egg of an infertile woman before the
egg is
fertilized.
This method involves removing the freshly
fertilized nucleus from an
egg that has little chance
of further development because
of age or disease and injecting it into the donor
egg.
The researchers then injected the
nucleus of an
egg from a second macaque,
fertilized the cell with sperm, and implanted it in the second monkey's womb.