Sentences with phrase «nude mice»

CSCs were prepared from 231BrM and CN34BrM cells that were infected with lentivirus carrying with or without miR -7-2, and they were transplanted into nude mice through intracardiac injection followed by monitoring metastatic tumor growth in the brain.

Treatment of nude mice bearing human TNBC tumors was initiated after the tumors had reached a volume of ~ 100 mm3 and lasted for five weeks.

None of the ten C57BL / 6 beige nude mice rejected BALB / c corneal allografts (Figure 2A).

iPS cells injected into athymic nude mice form teratomas and differentiate into all germ lineages in vivo (C, F, I).

We previously showed that follistatin can also block myostatin activity in vivo; specifically, we showed that follistatin can ameliorate the cachexia induced by high level expression of myostatin in nude mice [21] and that transgenic mice expressing follistatin in muscle have dramatic increases in muscle mass [19].

PP2A mediates diosmin p53 activation to block HA22T cell proliferation and tumor growth in xenografted nude mice through PI3K - Akt - MDM2 signaling suppression.

Peter HJ, Gerber H, Studer H, Becker DV, Peterson ME: Autonomy of growth and of iodine metabolism in hyperthyroid feline goiters transplanted onto nude mice.

Female nude mice (Harlan Laboratories) between 10 and 11 weeks of age (20g body weight) were housed in a climate - controlled environment with a 12 - h light / dark cycle and were fed standard laboratory diet with water ad libitum.

T lymphocytes are required for the rejection of corneal allografts, as athymic, T cell - deficient nude mice do not reject corneal allografts (3).

Request a custom bibliography search or select from our list of citations available on - line: Select one Agents Administered Biotechnology / Protein & Peptide Delivery Cancer Research Cardiovascular Research Endocrinology Gene Therapy Immunology Neuroscience Pharmacology Physiology Route of Agent Administration Toxicology / Teratology In Vitro Use Nude Mice Neonates

Antagonistic analogs of growth hormone - releasing hormone increase the efficacy of treatment of triple negative breast cancer in nude mice with doxorubicin; A preclinical study

Moreover, one compound substantially decreased the growth of human melanoma xenografts in nude mice without any apparent side effects.

Spleen cells (5 × 107) were injected intraperitoneally (i.p.) into C57BL / 6 beige nude mice.

To determine the in vivo developmental potential of our iPS lines, we injected iPS - 1 and iPS - 3 lines into athymic nude mice to induce teratomas.

Inhibition of SDF - 1 / CXCR4 interaction using an anti-CXCR4 monoclonal antibody significantly impairs the migration of breast cancer cells to regional lymph nodes and lung in nude mice [28].

Bruce Robinson, founder of the Diagram Group, a publishing solutions firm, established the first prize in 1978, with the crown going to Proceedings of the Second International Workshop on Nude Mice.

Peter HJ, Becker DV, Peterson ME, Gerber H, Studer H: Autonomy of growth and of iodine metabolism in hyperthyroid feline goiters transplanted onto nude mice.

Finally, a 2011 study from Paprotka, et al. provided strong evidence that XMRV is a 22Rv1 - derived laboratory contaminant originating from recombination of two mouse endogenous retroviruses during serial passage of CWR22 in nude mice [38].

«I think this might be related to the nude mouse,» the Harvard scientist suggested.

For experimental metastasis assay, nude mice (7 — 8 weeks) were injected with 50,000 luciferase - labeled CSCs in PBS into left cardiac ventricle in a total volume of 100 μL.

In these experiments, Berger and colleagues show that somatic PREX2 mutations identified through whole - genome sequencing of human melanoma can contribute to enhanced lethality of tumor xenografts in nude mice (Figure 3B, S6B, and S6C; Berger et al., 2012).

Nude mice were challenged with BALB / c corneal allografts one day after the adoptive cell transfers.

By contrast, 71 % (5/7) of the beige nude mice that received spleen cells from CD4 KO mice rejected their BALB / c corneal allografts.

In some experiments, one donor - equivalent of unfractionated spleen cells (5 — 8 × 107 cells / mouse) was transferred to each C57BL / 6 nude mouse.

Cell suspensions were enriched or depleted of CD8 + cells as described above and one donor - equivalent was transferred intravenously (i.v.) to each C57BL / 6 nude mouse.

Lymphoid cells were adoptively transferred to C57BL / 6 beige nude mice and DTH responses to BALB / c alloantigens were determined 24 hr later using a conventional footpad swelling assay.

Hedgehog inhibitor sonidegib potentiates (177) Lu - octreotate therapy of GOT1 human small intestine neuroendocrine tumors in nude mice.

BALB / c corneal allografts were transplanted to C57BL / 6 beige nude mice that received either CD8 − or CD8 + T cells from C57BL / 6 CD4 knockout (KO) mice that had rejected BALB / c corneal allografts.

Both CD8 − and CD8 + T cells from CD4 KO corneal allograft rejector mice mediated corneal allograft rejection following adoptive transfer to nude mice.

The Rac inhibitor EHop - 016 inhibits mammary tumor growth and metastasis in a nude mouse model.

The Rac inhibitor EHop - 016 Inhibits Mammary Tumor Growth And Metastasis In A Nude Mouse Model Translational Oncology PMID: 25389450 [PubMed] PMCID: PMC4225654.

Once the tissues matured and differentiated, they were transplanted onto the skin of a live and nude mouse.

Teratomas were generated from iPS clones 1 and 3 by subcutaneous injection of 1 × 106 cells into the dorsal flank of isoflurane - anesthetized athymic nude mice (Jackson Labs).

Studies on human cancer lines xenografted into nude mice have demonstrated anti-tumor activity of GHRH antagonists against multiple human cancer types.

Methods: HCC1806 (doxorubicin - sensitive) and MX - 1 (doxorubicin - resistant), cell lines were xenografted into nude mice and treated with MIA - 602, doxorubicin, or their combination.

[37 - 39] In this study, we used HCC1806 and doxorubicin - resistant MX - 1 human TNBC cell lines xenografted into nude mice to evaluate the effects of a GHRH antagonist (MIA - 602) alone and in combination with doxorubicin.

We have recently reported that the GHRH antagonist, MIA - 602, suppresses the expression of inflammatory cytokines in human TNBC tumors xenografted into nude mice.

: HCC1806 (doxorubicin - sensitive) and MX - 1 (doxorubicin - resistant), cell lines were xenografted into nude mice and treated with MIA - 602, doxorubicin, or their combination.

On the basis of studies on the XMRV - producing human prostate cancer cell lines CWR22Rν1 and CWR - R1 and their progenitor tumour xenograft CRW22, they concluded that XMRV infections were caused by contamination during in vivo passaging in nude mice.

Human head and neck squamous cell carcinoma cells transfected with mutant TP53 (SAS / mp53) or with neo vector (SAS / neo) were injected subcutaneously into hind legs of nude mice.

Cells were injected subcutaneously into nude mice (MCF7, 231, and 468) and NOD scid gamma mice (primary metastatic, COB9).

Finally, to determine whether LARP7 KD also results in an increase in breast cancer metastasis in vivo, the T47D control or shLARP7 - 2 cells were injected intravenously into the nude mice, and lung metastasis was examined 12 weeks later.

MDA - MB - 468 and MDA - MB - 231 cells carrying tet - shMELK were orthotopically implanted into the mammary fat pads of nude mice.