Sentences with phrase «null allele»

Our data suggest that certain presumed null alleles, although unable on their own to support basal transcription, may in fact have a substantial impact on disease outcome in compound heterozygous humans, as they do in mouse models.

Short guide RNA was targeted to the sequence corresponding to the CCHa2 peptide - coding region, resulting in the isolation of putative null alleles for CCHa2 (CCHa2CR - 1, CCHa2CR - 2, and CCHa2CR - 3)(Figs 5A and S5).

Long PCR detection of the C4A null allele in B8 - C4AQ0 - C4B1 - DR3.

Of the Iron Age individuals, three carry at least one Duffy null allele, protecting against malaria, and two have at least one sleeping - sickness - resistance variant in the APOL1 gene.

In a first step knock - out models with conditional potential (knock - out first allele, tm1a) will be produced from which tm1b null alleles can be derived for phenotyping

At low - density lipoprotein receptor (LDLR), carriers of rare non-synonymous mutations were at 4.2-fold increased risk for MI; carriers of null alleles at LDLR were at even higher risk (13-fold difference).

Red SNPs indicate discordant homozygous calls between MAGIC and BRLMM, which are indicative of the presence of «null alleles» (individuals lacking specific binding to either probe, usually because of a variant at the probe binding site).