Sentences with phrase «null alleles at»

At low - density lipoprotein receptor (LDLR), carriers of rare non-synonymous mutations were at 4.2-fold increased risk for MI; carriers of null alleles at LDLR were at even higher risk (13-fold difference).

Not exact matches

Of the Iron Age individuals, three carry at least one Duffy null allele, protecting against malaria, and two have at least one sleeping - sickness - resistance variant in the APOL1 gene.

Red SNPs indicate discordant homozygous calls between MAGIC and BRLMM, which are indicative of the presence of «null alleles» (individuals lacking specific binding to either probe, usually because of a variant at the probe binding site).