Sentences with phrase «null mice»
The phrase "null mice" refers to lab mice that have been genetically modified so they lack a specific gene. These mice are used in scientific research to understand the function and importance of that gene. Full definition
«The J20 / caspase -2 null mice showed the same dendritic spine density and morphology as the normal mice — as opposed to the deficits in the J20 mice,» said co-lead author Julio Pozueta, PhD.
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At 14 months, however, the J20 / caspase -2 null mice did significantly better in the water maze test than the J20 mice and similarly to the normal mice.
Irradiated Rassf1A null mice also showed increased tumor susceptibility, particularly to tumors associated with the gastrointestinal tract, compared with wild - type mice.
These results suggest that the additional muscle mass induced by follistatin in Mstn null mice results from inhibition of additional ligands that act predominantly to regulate muscle fiber growth.
The p21 - null mice also developed epithelial tumors (Table 2) ⇓.
While very high fat diets (i.e. 60 kcal % fat) are capable of inducing some atherosclerosis, the addition of cholesterol to such diets promotes more atherosclerosis in LDLr null mice (46).
Additionally, they examine MMTV - PyMT control or POSTN null mice to test the effect of POSTN on primary tumor growth and metastasis (Figures 3A, 3B, and S13; Malanchi et al., 2012).
The tumors arising in p21 - null mice derive from a variety of cell types and include hematopoietic (∼ 65 % of the tumors), endothelial (∼ 20 %), and epithelial (∼ 10 %) tumors.
A colony of p21 - null mice composed of 43 females and 30 males and a colony of wild - type mice (20 females and 10 males), all with the same genetic background C57BL / 6; 129Sv (50:50), were observed for the indicated period of time.
Human lymphoid and myeloid cell development in NOD / LtSz - scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cells.
Similarly, genetic silencing of Keap1 is insufficient to maximally activate HMOX1 gene expression in Keap1 null mice [52].
Analysis of transcriptomes in tumour tissues from wild - type mice and Slc6a14 - null mice indicated no compensatory changes in the expression of any other amino acid transporter mRNA.
More importantly, the satiating effects of high protein diets were abolished in PYY null mice [233].
Furthermore, TP63 has been implicated in human NSCL / P [44], and null mice recapitulate the human orofacial clefting phenotypes [45].
Lesion development is very dramatic in apoE null mice fed a Western - type diet and beginning stages of atherosclerosis (i.e. fatty streak lesions) can be found at 6 weeks (41).
Results: We demonstrate that Ad - B2 (− / −) mice display early onset lipodystrophy, in common with congenital Bscl2 null mice and CGL2 patients.
Some well known examples of genetically modified mice used in atherosclerosis research include the LDL receptor (LDLr) null and apolipoprotein E (apoE) null mouse which have mutations that hinder removal of circulating cholesterol by the liver.
Next generation sequencing of small RNA confirmed global suppression of miRNA and endogenous siRNA synthesis in ADAR1 - null mouse embryos.
The use of Western - type diets with added cholesterol (0.15 % - 1.25 % w / w) which are cholic acid free can induce significant atherosclerotic lesions after 12 weeks in LDLr null mice (38 - 40).
Analysis of the neurons showed that the J20 / caspase -2 null mice had a higher density of dendritic spines than the J20 mice.
Their embryos had more profound defects than were seen in the Esrp1 - null mice, including craniofacial and forelimb defects, and the complete absence of lungs and salivary glands — two organs made up largely of epithelial cells.
To investigate the functional role of melanopsin in light resetting of the oscillator, we generated melanopsin - null mice (Opn4 − / −).
To test this hypothesis, the researchers crossed J20 transgenic mice (a common mouse model of Alzheimer's) with caspase - 2 null mice (mice that lack caspase - 2).
In order to determine whether this effect of follistatin results solely from inhibition of myostatin activity, I analyzed the effect of this transgene in myostatin - null mice.
They want a null mouse for your gene that's prone to tumors.
Chen, X, Su, Y, Fingleton, B, Acuff, H, Matrisian, LM, Zent, R, Pozzi, A. Orthotopic models of lung cancer to follow primary and metastatic NSCLC growth in integrin α1 - null mice.
Finally, there are contradictory results concerning the susceptibility of p21 - null mice to chemically induced carcinogenesis of the skin (33, 34).