Sentences with phrase «null mouse embryos»

By contrast, Pou5f1 - null mouse embryos maintained the expression of orthologous genes, and blastocyst development was established, but maintenance was compromised.

Next generation sequencing of small RNA confirmed global suppression of miRNA and endogenous siRNA synthesis in ADAR1 - null mouse embryos.

Not exact matches

Their embryos had more profound defects than were seen in the Esrp1 - null mice, including craniofacial and forelimb defects, and the complete absence of lungs and salivary glands — two organs made up largely of epithelial cells.

These studies revealed that ADAR1 null mutant mouse embryos dye at mid-gestation due to widespread apoptosis and overwhelming interferon responses caused by activation of the dsRNA sensing mechanism mediated by MDA5 - MAVS signaling.