Sentences with phrase «null mouse which»

Not exact matches

By combining the follistatin transgene with a myostatin null mutation, I have been able to generate mice with quadrupled muscle mass, which represents yet another doubling of muscle mass compared to mice only lacking myostatin.

Current efforts are focused on defining the molecular mechanism underlying the embryonic lethal phenotype of ADAR1 null mutant mice and identification of the dsRNA (s), which triggers the MDA5 - MAVS - IFN pathway.

Interestingly, p21 - deficient mice did not develop T - cell lymphomas, which is one of the most common tumor types in p53 - null mice (36, 37, 38).

On the contrary, p21 deficiency delays the onset of radiation - induced T - cell lymphomas, which is in line with the delay in the appearance of spontaneous T - cell lymphomas produced by p21 deficiency in ATM - null mice (32).

It is interesting to note that p21 - deficient mice did not develop T - cell lymphomas, which is one of the most common tumor types in p53 - null and p19ARF - null mice (36, 37, 38, 42, 43).

The development of spontaneous tumors in p21 - null mice is in contrast to Bax - deficient mice, which do not develop tumors even after 2 years of age (44).

Flpe - and Cre - mediated recombination in vitro generated ES cell lines that contained a conditional or null Sema3B allele, respectively, which were established as homozygous alleles in mice.

The team transplanted stem cell - derived photoreceptors into another strain of mouse, called CRX null, which is congenitally blind.

The use of Western - type diets with added cholesterol (0.15 % - 1.25 % w / w) which are cholic acid free can induce significant atherosclerotic lesions after 12 weeks in LDLr null mice (38 - 40).