Sentences with phrase «null mutation»

Knockout Mouse Project Repository; mouse embryonic stem cells containing null mutations in every gene in the mouse genome.

Genomic (in) stability: We have established several cell lines and mice carrying null mutations for specific DNA repair functions.

28.04 % of tested genes with null mutations on a B6N genetic background have a phenotype association to abnormal behavior (1360/4850)

In mice in which the F66 transgene was combined with the Mstn null mutation, the two phenotypes appeared to be additive; that is, the quadrupling of muscle mass in F66 / Mstn − / − mice resulted from an approximately 73 % increase in fiber number and 117 % increase in fiber cross-sectional area.

By combining the follistatin transgene with a myostatin null mutation, I have been able to generate mice with quadrupled muscle mass, which represents yet another doubling of muscle mass compared to mice only lacking myostatin.

To understand the function of such silent genes, it will be necessary to obtain null mutations, just as in the case of genes causing obvious mutant phenotypes.

Resequencing of PRDM16 in a cohort of 75 non-syndromic individuals with LVNC detected 3 mutations, including 1 truncation mutant, 1 frameshift null mutation, and a single missense mutant.

Furthermore, homozygosity for null mutations at CYP2F1 was found associated with higher plasma interleukin - 8 concentrations; and at either A3GALT2 or NRG4, with markedly reduced plasma insulin C - peptide concentrations; hence identifying novel phenotypic associations at these genes.

Viable brain DA deficient flies were previously generated using tissue selective GAL4 - UAS binary expression rescue of a DTH null mutation and these flies show specific behavioral impairments.

Whole body null mutations in the gene encoding AR result in complete androgen insensitivity syndrome.

Homozygous mice carrying a null mutation for the DARPP - 32 gene exhibited minimal levels of P - facilitated sexual receptivity when compared to their wild - type littermates.

C57BL / 10ScCr mice are homozygous for a null mutation of Tlr4.

They also observed the same inability to suppress sleep while in starvation mode in the flies that carried a null mutation in translin.

The molecular analysis of the null mutations (totally non-functioning) of these genes allowed it to be observed that DNA - RNA hybrids accumulated (detected via a specific anti-hybrid antibody) and increased the genetic instability that they caused.

The Repository of mouse ES cell lines, strains and vectors generated by the trans - NIH KOMP initiative that aims to generate a public resource comprised of mouse embryonic stem (ES) cells containing a null mutation in every gene in the mouse genome.

The IMPC aims to generate a null mutation for every protein - coding gene in the mouse genome, to acquire broad - based phenotype data for each mutation, and to disseminate the mutant resource and phenotype data to the scientific community.

We investigated the role of myosin VI by examining the retinas of mice carrying a null mutation in the myosin VI gene.

These differences might be due to the difference between a null mutation, which eliminates all expression of the gene, and partial reduction of expression of GBP1 and GBP2 via RNAi.

But the importance of ApoC - III in TRL metabolism did not became fully apparent until it was shown that transgenic expression of APOC3 in mice resulted in hypertriglyceridemia (6), whereas a null mutation in the murine gene decreased plasma TG levels (7).

To test this hypothesis, R1, R1fs, and R1DeltaB2 transcripts were injected into embryos carrying a homozygous dcr - 2 null mutation, dcr - 2L811fsX.

For example, there is a fairly common genetic change related to Phase II detox that is called a null mutation of GSTM1.