Using clinical, genetic, and gene expression data as filters to distinguish genes whose copy
number alteration causes cancer from those for whom copy number changes are incidental, the team whittled down their list from 14,000 to a more manageable number, each of which they systematically tested using genetic experiments in animals.
Not exact matches
Sweeping
alterations to the electoral map of Britain
caused by the coalition's decision to cut the
number of MPs from 650 to 600 must be approved by October 2013 at the latest if they are to take effect at the planned 2015 general election.
Aneuploidy (an abnormal
number of chromosomes) is the most common genetic
alteration in human tumors and a major
cause for birth defects (Figure 4).
Errors in chromosome segregation are a major
cause for birth defects and embryonic lethality in humans, and the most common genetic
alteration in human tumors is aberrant chromosome
numbers, called aneuploidy.
These are characterized by glycosuria (presence of glucose in the urine, which is normally glucose - free), polyuria (excessive production and passage of urine), polydipsia (excessive thirst) and polyfagia (excessive appetite), as well as by a
number of serious metabolic
alterations caused by the inability of body cells to take up and use blood glucose, which is the main fuel for the body in normal conditions.
Physical activity, or the lack of it,
causes alterations in a
number of physiological parameters.
Variations in HR occur due to the constant need of the heart to adapt to changing circumstances, and it is thought that loss of balance of the sympathetic and parasympathetic nervous systems
causes an
alteration to the structure of HRV.5 6 HRV, as a measure of nervous system balance, can therefore provide a quantification of physiological changes associated with mental health disorders, with many studies investigating these associations through a
number of time domain, frequency domain and non-linear methods of quantifying HRV.7 — 9