Sentences with phrase «number alterations in»

These three chromosome arms harbor well - known oncogenes and tumor suppressor genes that have been shown to undergo copy number alterations in many cancers, including BC (Vogelstein et al., 2013).

Not exact matches

In addition to the large - scale alterations at its VIP locations, the company made a number of changes to its seating:

This is an important qualification for a number of reasons, most obviously that if one of the justifications for engagement in interreligious polemics is that it is heuristically valuable (as are its analogues in other dimensions of the intellectual life), then obviously revision, alteration, and abandonment of passionately held religious views must be a possibility.

In the past year we have made a number of alterations to the simulator, which should lead to more accurate predictions come tournament time.

Among patients with non-small cell lung cancer (NSCLC) fueled by ALK gene alterations who were being treated with crizotinib (Xalkori), a decrease in the number of circulating tumor cells (CTCs) harboring increased copies of the ALK gene over the first two months of treatment was associated with increased progression - free survival.

So if researchers can chart the changes in the number of salmon that swim upstream, they can get an accurate history of alterations in the ocean — which gives evidence of how climate has changed over time.

A strong, male - biased mutation spectrum was also measured, wherein three - quarters of mutations occurred in sperm thorough spermatogenesis, as well as new structural alterations, such as changes in gene conversion and copy number.

Through their analysis, the researchers determined the genetic alterations found in both the primary tumors and the metastases frequently were a type of genetic abnormality called a copy number alteration, which is when sections of DNA are repeated (i.e. duplicated).

Using clinical, genetic, and gene expression data as filters to distinguish genes whose copy number alteration causes cancer from those for whom copy number changes are incidental, the team whittled down their list from 14,000 to a more manageable number, each of which they systematically tested using genetic experiments in animals.

An analysis of published studies and reports indicates that a number of herbal products may affect the properties of prescription drugs, leading to alterations in the drugs» effectiveness as well as potentially dangerous side effects.

In this study, researchers assessed the outcomes of 280 prostate cancer (Cap) patients, and reviewed the DNA «fingerprints» of each patient's tumor (using the patient's initial diagnostic core biopsy) to determine if gene copy number alterations (CNAs), or breaks in CFSs, were related to a less positive response to treatmenIn this study, researchers assessed the outcomes of 280 prostate cancer (Cap) patients, and reviewed the DNA «fingerprints» of each patient's tumor (using the patient's initial diagnostic core biopsy) to determine if gene copy number alterations (CNAs), or breaks in CFSs, were related to a less positive response to treatmenin CFSs, were related to a less positive response to treatment.

In other words, alterations in the number of chromosomes, which can lead to a tumour process,» explains MontoyIn other words, alterations in the number of chromosomes, which can lead to a tumour process,» explains Montoyin the number of chromosomes, which can lead to a tumour process,» explains Montoya.

More recently, brain scans have directly linked these conditions with changes in levels of neurotransmitters — chemicals that convey messages across neurons — or alterations in the number or structure of neurons in different brain areas.

Telomere dysfunction — alterations in the structure and / or functioning of telomeres — is one of the molecular mechanisms underlying a number of age - related diseases but, to date, little is known about its possible role in pathologies of the liver such as cirrhosis, hepatitis and liver cancer.

The second is chromosomal complexity, which reflects how much of the genome in the cancer cells has copy - number alterations.

In this study, the authors assessed the impact of SNPs, inherited copy number variants (CNVs), and acquired copy number alterations (CNAs) on the gene expression landscape.

The possible expansion of the trial under the PMI ® will include adding new genetically targeted therapies to which patients can be matched and expanding the number of genetic alterations being studied in the trial.

Aneuploidy (an abnormal number of chromosomes) is the most common genetic alteration in human tumors and a major cause for birth defects (Figure 4).

Genome - wide detection of SVs and copy number alterations, which are often pervasive (and clinically relevant) in tumor genomes

Errors in chromosome segregation are a major cause for birth defects and embryonic lethality in humans, and the most common genetic alteration in human tumors is aberrant chromosome numbers, called aneuploidy.

Perhaps surprisingly, the authors find that somatic mutations occur at a continuous distribution in TNBC, and this appears independent of copy number alterations and tumor cellularity.

Especially in this vulnerable phase, the kidney is prone to a number of mechanistic changes driven by epigenetic alterations.

Copy number variation (CNV) is a common chromosomal alteration that can occur during in vitro cultivation of human cells and can be accompanied by the accumulation of mutations in coding region sequences.

Non-physiological alterations in chromosome number are well - established contributors to human disorders: they are responsible of a high percentage of miscarriages and a panel of diseases including Down syndrome, developmental disorders and cancer.

The main molecular alterations are represented by variations in gene expression, usually mild and with consequences for a vast number of target protein coding genes.

This section invites manuscripts describing (a) Linkage, association, substitution or positional mapping and epigenetic studies in any species; (b) Validation studies of candidate genes using genetically - engineered mutant model organisms; (c) Studies focused on epistatis and gene - environment interactions; (d) Analysis of the functional implications of genomic sequence variation and aim to attach physiological or pharmacogenomic relevance to alterations in genes or proteins; (e) Studies of DNA copy number variants, non-coding RNA, genome deletions, insertions, duplications and other single nucleotide polymorphisms and their relevance to physiology or pharmacology in humans or model organisms, in vitro or in vivo; and (f) Theoretical approaches to analysis of sequence variation.

To identify additional alterations, the investigators looked at DNA copy number changes, or changes in gene number resulting from the deletion or amplification (multiplication) of sections of DNA in the genome.

About 90 % of solid tumors display whole - chromosome aneuploidy, while many tumors with diploid karyotypes nonetheless harbor segmental or arm - length aneuploidies that also result in significant gene copy number alterations.

Additionally, we assess the phenotypic consequences of genomic copy - number alterations that are repeatedly observed in iPS cells.

Variations in the genetic code, from single point mutations to large structural or copy number alterations, influence susceptibility, onset, and progression of genetic diseases and tumor transformation.

Persistent inflammation induced by prolonged or repetitive exposure to specific allergens, typically characterized not only by the presence of large numbers of innate and adaptive immune cells (in the form of leukocytes) at the affected site but also by substantial changes in the extracellular matrix and alterations in the number, phenotype and function of structural cells in the affected tissues.

Several prototypes were tested that year, but the launch of the Nissan Primera in 1990 prompted Ford to made a number of major alterations to the final product, as it saw the new competitor from Nissan to be the benchmark car in this sector, having previously identified the Honda Accord as the class leader.

While there is a steady increase, you'll notice between 2007 and 2011 it jumps around a little bit, in terms of the funding amount a customer with LoanMart could receive1; these numbers also take into consideration factors such as modifications and alterations to both the interior and exteriors of the vehicles.

These are characterized by glycosuria (presence of glucose in the urine, which is normally glucose - free), polyuria (excessive production and passage of urine), polydipsia (excessive thirst) and polyfagia (excessive appetite), as well as by a number of serious metabolic alterations caused by the inability of body cells to take up and use blood glucose, which is the main fuel for the body in normal conditions.

Physical activity, or the lack of it, causes alterations in a number of physiological parameters.

Each chapter has a number of collectables in the form of a tie that you can dress Octodad in, and the trophies offer a few interesting and at times tricky alterations to a small number of objectives throughout the game.

The remade course is very accurate, with the only real alterations being the improved graphics and a slight widening to accomodate the number of cars in multiplayer races.

«Almost all the alterations resulted in higher temperatures being reported for the present and lower numbers for the past — with the higher numbers being used to demonstrate a historical warming trend — than the numbers that were actually recorded,» wrote Sterling.

Almost all the alterations resulted in higher temperatures being reported for the present and lower numbers for the past

Reduced number of lanes, changes in speed, alterations or detours to routes, presence of people and equipment on the road, and traffic jams are all contributing factors that generate a significant risk to the lives of both the construction workers and drivers.

The Federation Code provides in Rule 5.1 - 2A that «A lawyer must not counsel or participate in the concealment, destruction or alteration of incriminating physical evidence or otherwise act so as to obstruct or attempt to obstruct the course of justice,» and then adds a number of commentaries clarifying and addressing some of the complexities that can arise for a lawyer who receives such evidence.

Alteration Charge: An alteration fee of Rs 200 for reduction in sum assured / addition of riders is levied by cancelling the numberAlteration Charge: An alteration fee of Rs 200 for reduction in sum assured / addition of riders is levied by cancelling the numberalteration fee of Rs 200 for reduction in sum assured / addition of riders is levied by cancelling the number of units.

You will be responsible for reaching sales goals and improving the sales numbers by identifying areas that are in need of alterations.

Variations in HR occur due to the constant need of the heart to adapt to changing circumstances, and it is thought that loss of balance of the sympathetic and parasympathetic nervous systems causes an alteration to the structure of HRV.5 6 HRV, as a measure of nervous system balance, can therefore provide a quantification of physiological changes associated with mental health disorders, with many studies investigating these associations through a number of time domain, frequency domain and non-linear methods of quantifying HRV.7 — 9