Sentences with phrase «number of all other genes»

The researchers now are studying some of the master genes to determine whether modifying them also causes changes in large numbers of other genes.

This doubles the number of all other genes known on the planet.

Like SIR2 in yeast, sir - 2.1 may exert its effect by shutting down a number of other genes.

«We're continuing to test a number of other genes to see if one strikes us as being a very potent modifier of type 1 diabetes,» he adds.»

This gene, along with a number of other genes encoding proteins involved in nickel homeostasis, has been acquired a long time ago by the bacterium via horizontal gene transfer.

Because you have her whole genome, and not just a test for a single gene, you can potentially look for a vast number of other gene variants that raise the risk of other diseases of adulthood, such as the BRCA1 gene for breast cancer.

In contrast to ospC, a number of other genes on cp26 encodes proteins of presumed physiologic significance to the spirochete (39 - 43).

A number of other genes, including MAOA — the so - called «warrior gene», which affects neurotransmitters such as dopamine, norepi - nephrine and serotonin — have also been identified as undergoing methylation in response to early life adversity.

Not exact matches

Even with the phenotype, perhaps there is a «trade off involved» in that the same underlying genetic sub-scripts serve other purposes, or perhaps the sheer numbers of gene - hormonal permutations mean it will always manifest itself due to pure statistics.

For other couples, gene editing could increase the number of healthy embryos available by fixing some that would otherwise be thrown away, Amato says.

For a very small number of genes, though, people inherit only one working copy; the other copy is turned off, forever silenced.

The Duke researchers who made this discovery say it may help explain how a relatively small number of genes can create the dazzling array of different cell types found in human brains and the nervous systems in other animals.

This study showed the two subtypes have different genetic origins and involve a dramatically different number of chromosomal rearrangements, mutations and other gene variations.

A total of 21,257 genes were identified, a number similar to that of human beings and other mammals, and they have been compared to those of cats, tigers, cheetahs and dogs.

In this research, the group looked at two variants of miR - 21, a microRNA «oncomiR» known to target tumor suppressor genes and which is highly expressed in a number of cancers as well as other proliferative diseases such as psoriasis.

«It's very possible that other researchers and clinicians could use this type of gene editing to explore ways to cure a large number of diseases.»

The elimination of this host factor via the deletion of the FREP1 gene had other effects besides reducing the number of mosquitoes infected with malaria.

Results from the analysis confirmed previous findings of some copy number variants already associated with autism, but they also found a host of other genes (SHANK2, SYNGAP1, DLGAP2 and the X chromosome — linked DDX53 - PTCHD1 locus) in which mutations seem to be linked to autism.

It is only when these same cognate TFs act as noncognate TFs for other genes, or that new binding sites in the promoter drastically increase the number of noncognate binding configurations, that crosstalk constraints become clear.

A peek at tardigrades» genetic diaries may dispel a rumor about an amazing feat the tiny creatures were supposed to perform: borrowing large numbers of genes from other organisms.

She also says that other recent work confirms that it's possible to compute the impact of large numbers of genes using simple arithmetic.

Kayser's team plans to hunt for other genes, by increasing the number of landmarks they evaluate and acquiring MRIs of more people.

The site's newest sections describe the growing number of fly genes known to have close relatives in other animals, including humans — evidence, researchers are discovering, that the animal kingdom is interwoven genetically by its own worldwide web.

In the illustration, each tissue type is followed by the number of genes whose level of activity is controlled by nearby genes on the same chromosome (cis); those whose activity is associated with genes on other chromosomes (trans); and the number of tissue samples studied.

Surprisingly, these conserved gene sets were also associated with several other biological traits, which evolved multiple times in ants, such as number of queens in a colony, whether an ant species is invasive or not, and the degree of worker sterility.

Most researchers believed that the Y chromosome of cattle would be similar to the Y chromosome of other mammals, which does not have a large number of genes and is considered mostly transcriptionally inactive, Liu said.

A new genetic analysis reveals that our brawny cousins had a number of distinct genes involved in the buildup of certain types of fat in their brains and other tissues — a trait shared by today's Europeans, but not Asians.

For example, when the researchers decoded the complete sequence of one extrachromosomal circular phage from a disease - causing Staphylococcus, they identified a number of genes that may help this strain evade a host's immune system and that could readily spread to other Staphylococcus bacteria.

Surveillance that is not stringent enough, on the other hand, would allow eggs with a lot of jumping gene - related errors to survive, and lead to a high level of birth defects, such as those caused by an incorrect number of chromosomes in the offspring.

Probably a number of embryonic genes, after being turned off for decades, are reexpressed in cancer cells, enabling those cells to regain their embryonic capacity to move around and invade other tissues.»

NF - κB: Inhibition of this gene extends life modestly in a number of lower species, though given its involvement in immunity, inflammation, apoptosis, and other fundamental processes, there is an embarrassment of riches when it comes to trying to explain the roots of the effect.

Testing for additional genes in the pathway and in a number of pathways is done through a number of commercial resources; the only other clinically relevant test is the homologous recombination defect assay, which is commercially available from Myriad Genetics.

The Nature Genetics studies add another four — MS4A, CD2AP, CD33, and EPHA1 - and contribute to identifying and confirming two other genes, BIN1 and ABCA7, thereby doubling the number of genes known to contribute Alzheimer's disease.

A dizzying number of genetic transcripts, proteins and other molecular players alternatively glom together or fall apart, turning on or tuning down countless patterns of gene expression that keep our cells, organs and bodies humming along with the Earth's daily rotations.

Although counterintuitive, this is reminiscent of the way certain pluripotent stem cells in other systems express a greater number of genes — including more ancient genes — than their somatic daughter cells do.

Similarly, other genes involved together with DHCR7 in the cholesterol biosynthesis pathway, are also associated with a number of genetic disorders / syndromes (e.g., Antley - Bixler syndrome — POR gene), presenting with several common prenatal clinical manifestations (Porter & Herman, 2011).

If it's a noisy, random process, however, the two genes» activity would differ, with some cells producing lots of green and others lots of red, or any number of other variations.

All of the significant regions had been previously reported / validated; they included or were proximal to a number of well - known cancer genes including EGFR, CCND1, KRAS, MDM2, PDGFRA, and others.

There are also many other differences in the number or coding sequences of ankyrin repeat genes between wMel strain genomes and wAu [21], [49](see also [15] and [48] for sequence of wMelCS).

The study convincingly showed that chromium supplementation «upregulated» a number of genes — causing them to become more active — while others were «downregulated.»

This section invites manuscripts describing (a) Linkage, association, substitution or positional mapping and epigenetic studies in any species; (b) Validation studies of candidate genes using genetically - engineered mutant model organisms; (c) Studies focused on epistatis and gene - environment interactions; (d) Analysis of the functional implications of genomic sequence variation and aim to attach physiological or pharmacogenomic relevance to alterations in genes or proteins; (e) Studies of DNA copy number variants, non-coding RNA, genome deletions, insertions, duplications and other single nucleotide polymorphisms and their relevance to physiology or pharmacology in humans or model organisms, in vitro or in vivo; and (f) Theoretical approaches to analysis of sequence variation.

Therapy using live cells is increasingly used to replace damaged tissue, deliver gene therapies to target tissues and organs, and stimulate self - healing along with a number of other applications.

This approach may also be applicable to a number of rare genetic diseases caused by splicing defects, including ataxia telangiectasia, congenital disorder of glycosylation, and Niemann - Pick disease type C. Although the three DMD studies referenced here represent a great step forward for CRISPR gene therapy, it's important to realize that DMD is a simpler case than other genetic diseases we'd like to treat with CRISPR.

DLGAP2, the other gene listed in the accompanying graphic, has also been implicated in the development of autism in a copy number variation (CNV) analysis of people with ASD.

To understand the selection mechanism behind mutations, network - based studies were used to estimate the importance of a mutated protein compared to non-mutated ones in signalling and protein — protein interaction networks.10, 11,12,13 Proteins mutated in cancer were found having a high number of interacting partners (i.e., a high degree of connectivity), which indicates high local importance.10 Mutated proteins are also often found in the centre of the network, in key global positions, as quantified by the number of shortest paths passing through them if all proteins are connected with each other (i.e., they have high betweenness centrality; hereafter called betweenness).11, 12 Mutated proteins also have high clustering coefficients, which means their neighbours are also neighbours of each other.10, 13 Moreover, neighbourhood analysis of mutated proteins have been previously successfully used to predict novel cancer - related genes.14, 15 However, to the best of our knowledge, no study has concentrated particularly on the topological importance of first neighbours of mutated proteins in cancer, and their usefulness as drug targets themselves.

What was humbling was that, when the number of genes in human cells were counted and compared to other organisms, our genome was considerably smaller than that of many other species.

calypso dance at Mitchum here is easily the best scene in the film), but she's never appealed to me as much as say, Gene Tierney or any number of other, similar stars of the 40s, and at 39 in this film, she's a bit past her (overrated) prime.

A number of different breeds contributed to the gene pool of the Rhodesian Ridgeback including the Bloodhound, Greyhound, Pointer, Mastiff, Airedale, and Africa's Hottentot Dog, among others.

The mutation of the MLPH gene which is responsible for dilute color in a number of other breeds is present in the Aussie.

The most recessive version of K is ky; two copies of ky will allow another gene, A (agouti,) to express itself in a number of patterns commonly seen in other breeds, such as tan points.