Not exact matches
There seemed to be a direct relationship between the presence
of CD33 and the
number of destructive
amyloid plaques.
They found no difference in the
number of plaques or the total amount
of amyloid beta between the mice that received the compound and those given just saltwater.
Once again, decreasing the
number of receptors improved memory, even in the presence
of amyloid plaques characteristic
of Alzheimer's.
Characteristic neuropathological findings were focal depletion
of diffuse and neuritic
plaques, but not
of amyloid angiopathy, and the presence
of small
numbers of extremely dense (collapsed)
plaques surrounded by active microglia, and multinucleated giant cells filled with dense Abeta42 and Abeta40, in addition to severe small cerebral blood vessel disease and multiple cortical hemorrhages.
''... we hypothesize that repeated stress - related allostatic overload may affect brain function at three basic levels: (a) at the cellular level, it may compromise proteostasis (e.g. tau protein), organelles homeostasis, and induce epigenetic changes in neuronal DNA; (b) at the tissue level it may affect intracellular communication (synaptic contacts),
number of cells (reduction
of neuronal density), composition
of the extracellular matrix (accumulation
of amyloid plaques), and neuroinflammation; (c) at the systemic levels it may alter the brain's regulation
of behavior (cognitive decline).
Packed with powerful antioxidants such as resveratrol and quercetin, berries» sky - high levels
of flavonoids help to increase the
number of connections between brain neurons — while helping to disrupt the
amyloid plaques found in the brains
of Alzheimer's disease patients.