Sentences with phrase «number of cell lines»

The number of cell lines can also vary depending on the experiment being implemented; one could test a handful of cell lines, or hundreds of them.

Finkbeiner's team has already characterized a number of these cell lines for differences between people with the disease and their unaffected family members.

Recent studies highlighted significant differences between these two types of stem cells, although only a limited number of cell lines of different origins were analyzed.

Cell lines are therefore indispensable in medical research and a large number of cell lines exist that originate from many different tumor types.

That summer, President George W. Bush had approved federal funding for human ES - cell research, but only for a small number of cell lines that had already been created.

Not exact matches

In August of last year, President Bush approved the use of federal funds to support research on a limited number of existing human embryonic stem cell lines.

Phone numbers were dialed from samples of both standard land - line and cell phones.

For instance, a growing number of households no longer have land lines, but rely on their cell phones instead.

Nevertheless, Vallier is concerned about the number of changes in the reprogrammed cell lines.

Congressional supporters of stem cell research have re-introduced legislation to codify President Barack Obama's 2009 executive order lifting restrictions on the number of human embryonic stem cell lines available to federally funded researchers.

Despite the presumed virulence of the strain — experiments with mouse lungs showed it produces 1000 times more bacteria in infected cells than do standard varieties — Valway says the number of TB cases that developed were kept in line with other typical outbreaks, which «shows that doing good contact investigations is important and preventative therapy works.»

In addition, where cells derived from embryonic stem cells are great at proliferating — a potentially critical feature if one wants to grow sufficient numbers of cells for clinical use — ones from the iPS lines were much feebler.

Collins and others argue not just for a permanent removal of the injunction to resume research with confidence, but also for an extension of the number of embryonic stem cell lines available to federally funded researchers.

He has also been an inveterate foe of abortion, a position that informed his repeated votes against expanding the number of human embryonic stem cell lines available to NIH - funded researchers during the George W. Bush administration.

Under the Obama administration, the number of embryonic stem cell lines available for federally funded research had more than tripled, but no money was going toward the creation of any cell lines (a process that destroys the embryo).

The team found the most influential factors included the number of cells that developed into early stage embryos, the thickness of the womb lining, and body mass index.

When they sequenced the iPS cell lines, they found higher numbers of mitochondrial DNA mutations, particularly in cells from patients older than 60.

«We can work with any embryonic stem cell line from any source and are not restricted to working with the very small number of federally approved lines as is the case for researchers in the United States,» says Minger.

«We believe an overwhelming number of these altered cells reach the lining of the abdominal cavity, survive and grow,» Bulun said.

These human cells were ineligible for federal research funds because they had been created after President Bush's August 9, 2001, announcement freezing the number of government - approved stem cell lines.

They used the gene editing technology CRISPR to engineer a series of human embryonic stem cell lines, which were identical apart from the number of DNA repeats that occurred at the ends of their HTT genes.

The causes of such unpredictable results, Harris said, can include bad ingredients in the lab, including contaminated and misidentified cell lines; poor research design, including insufficient numbers of mice in animal studies; statistical error and overreach, including «HARKing» (hypothesizing after the results are known), a push beyond the limits of the data; and funding pressures, which can lead scientists to hype or exaggerate their results to remain competitive for additional grant money.

The team used light and electron microscopy to show that lymphatic endothelial cells, which line the interior surface of the lymph node capsule, contain a number of channels that penetrate the whole thickness of the cells.

If a woman has an abortion, she's left with a large number of these immature cells lining her breast ducts, and she is therefore more vulnerable to cancer down the road — 30 percent more vulnerable, Brind says, than a woman who has never had an abortion.

In the study, the researchers detected a very small number of SIV infected cells in the gut within initial 2.5 days of viral infection; however, the inflammatory response to the virus was playing havoc with the gut lining.

The limited number of permissible cell lines left, Melton says, can not meet the medical needs of a population as genetically diverse as the human race.

But scientists have struggled for years to harness the small number of T cells, the immune system's first line of defense, that are thought to fight these tumors.

Tübingen neurology researchers can now report how and where brain cells depict an empty set as a part of the number line.

University of Tübingen neuroscience researchers headed by Professor Andreas Nieder now have some answers as to how and where brain cells depict a zero amount as a part of the number line.

«We wanted to see whether very - large - scale screening across a diverse collection of cancer cell lines and a large number of drugs could yield new combinations for patients with cancer,» says Adam Friedman, MD, PhD, of the CBRC and the MGH Cancer Center, who led the study.

More than 5,775 potential drug combinations, as well as each single drug, were screened against each cell line, looking for effects on the number and viability of tumor cells.

«The use of nonhuman oocytes for SCNT is currently the only ethically justifiable option given the large numbers of eggs required to derive cloned human stem cell lines,» he said.

ReNeuron can generate large numbers of stable cell lines by engineering cells with a modified version of the gene c - myc.

Using a new TaqMan PCR - based technique, the researchers screened a number of cancer cell lines from various tissues, and discovered that tRNA halves were specifically expressed in large quantities in sex hormone - dependent cancers, i.e., estrogen receptor (ER)- positive breast cancer and androgen receptor (AR)- positive prostate cancer that are driven by the hormones estrogen and testosterone.

The selection strategy targeted cell populations expressing the inducible endothelial cell adhesion molecules, E-selectin and VCAM - 1, and proved successful in generating microvascular endothelial cell lines from a number of different organs.

However, efforts to examine the in vitro behavior of tumor cells with endothelial cells from different anatomical regions have been prohibited because, in large part, of the limited number of organ - derived endothelial cell lines available for study.

The discovery of NGF has also promoted an intensive search for other specific growth factors, leading to the isolation and characterization of a number of proteins with the ability to enhance the growth of different cell lines.

Number of experiments: n = 15 (XpdTTD / TTD), n = 6 (XpdTTD / KO), n = 4 (XpdTTD / † XPCS), n = 2 (XpdTTD / † XP); 1 — 2 cell lines per genotype were included in each experiment.

Three years ago, an I - Stem team identified a genomic anomaly that very frequently appeared in undifferentiated cell lines when the latter were forced to perform too great a number of proliferation cycles.

NCI's efforts to develop new laboratory models of human cancer includes vastly increasing the number of human cancer cell lines (grown as two - dimensional and three - dimensional cultures) and patient - derived tumor xenografts.

It aims at producing cell lines that are to be broadly available for manufacturing cell therapies matching the widest possible number of récipients.

We have also have adopted a number of lines of study into the regulation of cytokine production and effector cell responses such, as cytotoxicity, in the response of Vα14 iNKT cells to glycolipid antigens or IL - 12 from activated DCs.

\ n \ nIn other words this is a political attempt, based on a technicality, to advance science in the field by getting the US Administration to greatly expand the number of human ES - cell lines that can be used under federal funding.

take a lead in developing the next generation of cancer cell lines and use cell lines to systematically explore in vitro sensitivity to large numbers of anticancer drugs and drug combinations in order to inform choice of cancer types for early drug trials.

SCNT requires a large number of eggs and produces very few stem cell lines.

Stem cell researchers from UCLA used a high resolution technique to examine the genome, or total DNA content, of a pair of human embryonic stem cell lines and found that while both lines could form neurons, the lines had differences in the numbers of certain genes that could control such things as individual traits and disease susceptibility.

In this study, Teitell and his team sought to determine copy number variants (CNVs), or differences in the numbers of certain genes, in two embryonic stem cell lines.

By collecting and banking your stem cells — especially while you are healthy — you are collecting a large number of stem cells and an array of differentiated cell lines, including the ones committed to form immune cells.

RNA - seq analysis of the tumor cell line revealed a number of silenced genes (presumably including many tumor suppressors).

«Basically, this study shows that the genetic makeup of individual human embryonic stem cell lines is unique in the numbers of copies of certain genes that may control traits and things like disease susceptibility,» said Teitell, who also is an associate professor of pathology and laboratory medicine and a researcher at UCLA's Jonsson Comprehensive Cancer Center.