Sentences with phrase «number of changes over the years»

From the early days of Mayan civilization and the logging of 1600s to the recent explosion of offshore banking and tourism, the economy of the country has undergone a number of changes over the years.

Games have undergone a number of changes over the years, these changes encompass every aspect of video games.

Christian Whitehead's original fan game underwent a number of changes over the years, and was one of the first Sonic fan games to closely match the feel of the Mega Drive classics.

Not exact matches

Over the years, there have been a number of changes to the c - suite.

We referenced their numbers when we looked at the changing anatomy of U.S. oil imports, or when showing the decline in coal use over recent years.

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

Over the last year and a half a number of prominent voices in the Bitcoin community have been warning that the system needed to make fundamental changes to its core software code to avoid being overwhelmed by the continued growth of Bitcoin transactions.

The chart below shows the rate of change in bitcoin and the number of Coinbase users over the last four years (thanks to @alistairmilne for the user data).

The percentage beside each city shows how the number of homes for sale has changed over the last five years.

Climbing Mount Improbable, Dawkins» most recent popular work, 9 is mainly a refutation of arguments put forward over many years by a number of distinguished physical scientists who have claimed that biological evolutionary change by natural selection is intrinsically unreasonable, using arguments from probability theory.

And she didn't change her mind over night she changed her mind over a number of years.

Over the past few years, Columbus has made a number of changes to its personnel and the result is «a really nice blend of people who have been with the company for a very long time and people who have come to the organization in the recent past,» Todd says.

Nothing stays the same, though, and football over the years has seen any number of tactical changes, so I wonder if we are now coming to the end of tiki - taka in favour of a more athletic, robust and high pressing style of football.

This is an incredibly difficult question to answer for a variety of reasons, most importantly because over the years our once vaunted «beautiful» style of play has become a shadow of it's former self, only to be replaced by a less than stellar «plug and play» mentality where players play out of position and adjustments / substitutions are rarely forthcoming before the 75th minute... if you look at our current players, very few would make sense in the traditional Wengerian system... at present, we don't have the personnel to move the ball quickly from deep - lying position, efficient one touch midfielders that can make the necessary through balls or the disciplined and pacey forwards to stretch defences into wide positions, without the aid of the backs coming up into the final 3rd, so that we can attack the defensive lanes in the same clinical fashion we did years ago... on this current squad, we have only 1 central defender on staf, Mustafi, who seems to have any prowess in the offensive zone or who can even pass two zones through so that we can advance play quickly out of our own end (I have seen some inklings that suggest Holding might have some offensive qualities but too early to tell)... unfortunately Mustafi has a tendency to get himself in trouble when he gets overly aggressive on the ball... from our backs out wide, we've seen pace from the likes of Bellerin and Gibbs and the spirited albeit offensively stunted play of Monreal, but none of these players possess the skill - set required in the offensive zone for the new Wenger scheme which requires deft touches, timely runs to the baseline and consistent crossing, especially when Giroud was playing and his ratio of scored goals per clear chances was relatively low (better last year though)... obviously I like Bellerin's future prospects, as you can't teach pace, but I do worry that he regressed last season, which was obvious to Wenger because there was no way he would have used Ox as the right side wing - back so often knowing that Barcelona could come calling in the off - season, if he thought otherwise... as for our midfielders, not a single one, minus the more confident Xhaka I watched played for the Swiss national team a couple years ago, who truly makes sense under the traditional Wenger model... Ramsey holds onto the ball too long, gives the ball away cheaply far too often and abandons his defensive responsibilities on a regular basis (doesn't score enough recently to justify): that being said, I've always thought he does possess a little something special, unfortunately he thinks so too... Xhaka is a little too slow to ever boss the midfield and he tends to telegraph his one true strength, his long ball play: although I must admit he did get a bit better during some points in the latter part of last season... it always made me wonder why whenever he played with Coq Wenger always seemed to play Francis in a more advanced role on the pitch... as for Coq, he is way too reckless at the wrong times and has exhibited little offensive prowess yet finds himself in and around the box far too often... let's face it Wenger was ready to throw him in the trash heap when injuries forced him to use Francis and then he had the nerve to act like this was all part of a bigger Wenger constructed plan... he like Ramsey, Xhaka and Elneny don't offer the skills necessary to satisfy the quick transitory nature of our old offensive scheme or the stout defensive mindset needed to protect the defensive zone so that our offensive players can remain aggressive in the final third... on the front end, we have Ozil, a player of immense skill but stunted by his physical demeanor that tends to offend, the fact that he's been played out of position far too many times since arriving and that the players in front of him, minus Sanchez, make little to no sense considering what he has to offer (especially Giroud); just think about the quick counter-attack offence in Real or the space and protection he receives in the German National team's midfield, where teams couldn't afford to focus too heavily on one individual... this player was a passing «specialist» long before he arrived in North London, so only an arrogant or ignorant individual would try to reinvent the wheel and / or not surround such a talent with the necessary components... in regards to Ox, Walcott and Welbeck, although they all possess serious talents I see them in large part as headless chickens who are on the injury table too much, lack the necessary first - touch and / or lack the finishing flair to warrant their inclusion in a regular starting eleven; I would say that, of the 3, Ox showed the most upside once we went to a back 3, but even he became a bit too consumed by his pending contract talks before the season ended and that concerned me a bit... if I had to choose one of those 3 players to stay on it would be Ox due to his potential as a plausible alternative to Bellerin in that wing - back position should we continue to use that formation... in Sanchez, we get one of the most committed skill players we've seen on this squad for some years but that could all change soon, if it hasn't already of course... strangely enough, even he doesn't make sense given the constructs of the original Wenger offensive model because he holds onto the ball too long and he will give the ball up a little too often in the offensive zone... a fact that is largely forgotten due to his infectious energy and the fact that the numbers he has achieved seem to justify the means... finally, and in many ways most crucially, Giroud, there is nothing about this team or the offensive system that Wenger has traditionally employed that would even suggest such a player would make sense as a starter... too slow, too inefficient and way too easily dispossessed... once again, I think he has some special skills and, at times, has showed some world - class qualities but he's lack of mobility is an albatross around the necks of our offence... so when you ask who would be our best starting 11, I don't have a clue because of the 5 or 6 players that truly deserve a place in this side, 1 just arrived, 3 aren't under contract beyond 2018 and the other was just sold to Juve... man, this is theraputic because following this team is like an addiction to heroin without the benefits

Over the last decade, the average number of managerial changes per season has been nine, up from an average of six for the previous ten years before that.

They've been imperious at home this season, where they are undefeated in 26, winning 23, and although Sir Alex Ferguson has confirmed he will make a number of changes from the side which comfortably secured victory in the first leg over in Germany, the 69 - year - old has assured fans that the defence will still posses plenty of experience, which is a smart move on his part, as so long as United don't concede, a feat they've achieved in 15 of 26 home games this season, they'll sail through.

Publication of the Purdue study sent shock - waves reverberating through the football world, with the findings cited by concussion experts calling on youth sports organizations to take more aggressive action to minimize exposure to RHI, including sub-concussive blows, by changing the way contact and collision sports are played and practiced, and reducing the amount of brain trauma a child incurs by limiting the number of hits they sustain in a sports season, over the course of a year, and during a career.

In 1930, the company produced 842,000 cans of baby food; by 1931 the number had risen to 1,311,500 cans; one year later, in 1932, Gerber manufactured 2,259,818 cans of baby food.65 Despite competitors» quick development of their own mass - produced strained baby foods, Gerber dominated U.S. market share over such competitors as Clapp's, Heinz, Beech - Nut, Stokeley, and Libby.66 The new baby food products were so successful that by 1941 the Fremont Canning Company changed its name to Gerber's Baby Foods (and in the 1960s became the Gerber Products Company), and two years later it abandoned its line of regular vegetables to make baby foods exclusively.

The figure of course depends on the number of diaper changes a day and the age at toilet training, but assuming an average two and a half - year diapering period, and an average of eight to ten diaper changes a day this translates to 7,000 to 9,000 diapers over the diapering period.

And that's before accounting for some of the factors that the model doesn't consider: the disagreement in the polls, the unusual nature of Trump's candidacy and the demographic changes it is producing, Clinton's superior turnout operation, the possibility of «shy Trump» voters, the fact that the news cycle is still somewhat fluid headed into the final weekend, the declining response rates to polls, and the substantial number of high - profile polling misses around the world over the past few years.

The committee will also discuss several technical changes relating to an annual report produced by the Administration for Children's Services and the Department of Youth and Community Development on the number of sexually exploited youth each agency has come into contact with over the course of the calendar year.

The bulk of the report focuses on changes to be made over the next 10 years, including criminal justice reforms aimed at lowering the number of people in city jails.

Federal money from a Medicaid waiver: After they enacted a number of changes designed to bend the long - term cost curve of the state - federal Medicaid program, New York officials applied for a federal waiver that would let the state invest $ 10 billion of $ 17 billion in savings over the next five years.

A proposed Milwaukee County rule change that would define small business enterprises as those that make $ 4 million or less per year faces further debate over the validity of the number.

The number and size of the fellowship program areas has changed over the years and continues to evolve.

Researchers have found over the years that any number of factors — weather changes, chocolate, sleeping patterns, alcohol, stress, odors and so on — can trigger migraine headaches in different people.

By observing lizards in the field, Sinervo and a colleague showed that the number of lizards employing the strategies of aggression, cooperation, and deception fluctuated over the course of 6 years, the dominant strategy changing as new lizards were born.

The number of experimentally determined protein structures is quite small at the moment, but this will change markedly over the next 5 years.

A number of theories have been developed over the years to explain more recent extinctions such as those at the end of the last ice age, including human hunting, climate change, disease, and even a cosmic impact such as an asteroid or comet.

Secondly, the authors of the dictionary — and this is an easy criticism of a work which has emerged over a number of years and can not be expected to keep up with every change in common usage — will need to pay attention to the influence of political correctness, which has resulted in changes to many signs in BSL in recent years.

By tuning the model to replicate population data, such as the number of people at risk for developing TB and the fraction of TB patients who have drug resistance, the model can predict changes in the TB disease burden — or number of cases — over many years.

Severe hurricanes, storm surges and an increase in the number of icebergs are just some of the changes planet Earth has experienced due to warming oceans over the last 20 years, according to a new report.

This finding may have potentially been due to the relatively low number of participants who made significant changes to their tea consumption over a 4 - year period thereby limiting statistical power to detect true associations.

Over the past year, a number of prominent Republican voices have argued their party must rethink its long - standing opposition to measures designed to address climate change.

The sun's activity shifts over the course of its 11 - year cycle, with sun spot numbers, radiation levels, and ejected material changing over time.

1:28 Her health struggle and how she came to real food 2:25 Her lightening bolt moment and how she made lasting changes 3:15 Her «last supper» 5:23 The factors that helped her with quitting sugar, lose 60 lbs, and keep it off for over 15 years 6:16 How accountability helped her 7:23 How long it takes to detox from sugar and how to do it 8:20 Why she has hope for the health of future generations 10:45 Natural pregnancy, parenting, and birthing tips 16:00 The crunchy thing she can't do and the crunchiest thing she's ever done 16:45 The thing she recommends to help have a natural birth — Hint: it starts in the 2nd trimester 17:46 Why Fermented Cod Liver Oil & exercise can improve birth 18:00 Tips to help baby's position before birth 19:00 Crunchyest thing she's ever tried, and what weird foods she ate after she gave birth 21:28 Her best advice for listening to your body 23:00 Number one health step to take now 24:07 The book she recommends everyone should read

From packing 20 pounds of muscle onto a skinny vegetarian, to getting a life long couch potato to lose over 83 pounds in just 5 months, to creating the Number ONE program for helping people lose the last few pounds, I've spent the last 12 years helping people change their lives and bodies.

I've changed a lot in the way I dress over the years, I used to have a number of very low cut tops, I cringe thinking about it now.

Now, with online dating sites and apps, your potential partner... add a privacy layer to your real number with either a Google Voice number or a Burner... Over the past year, online dating service OkCupid has shaken up a few of its core features, and the changes have all pushed the service far Read More...

The sacred element of marriage has changed dramatically over the decades, it doesn't hold the same tradition or relevance it once did, but there are those out there who have been married for several years, but «Hope Springs» addresses the concept of being «happily married», a term that is thrown around all too frequently these days, Kay (Meryl Streep) and Arnold (Tommy Lee Jones) are said couple, married for 31 years as Arnold keeps reminding us, reminding us because Kay knows the spark is gone, and Arnold uses this fun fact to remind her, just because the number is there doesn't mean it's a happy one.

Over the years, the number of nominations changed.

A number of prominent Conservative MPs on Theresa May's Cabinet, including Liam Fox and David Davis, have been vocal proponents of grammar schools, and Education Secretary Justine Greening has said that the government should be «open minded» to the idea of new grammar schools as the education landscape has changed over the last few years.

Reimers says he looked at a number of case studies and evaluations, as well as conducted interviews of business leaders, military officials, and the intelligence community in order to gauge how much change has occurred in foreign area expertise and foreign language over the past 50 years.

«We have introduced a number of changes to the examination system in Wales over the past year.

Our studies use variation from one year to the next in snow or the number of instructional days cancelled due to bad weather to explain changes in each school's test scores over time.

Year 6 Science Assessments and Tracking Objectives covered: Describe how living things are classified into broad groups according to common observable characteristics and based on similarities and differences, including micro-organisms, plants and animals Give reasons for classifying plants and animals based on specific characteristics Identify and name the main parts of the human circulatory system, and describe the functions of the heart, blood vessels and blood Recognise the impact of diet, exercise, drugs and lifestyle on the way their bodies function Describe the ways in which nutrients and water are transported within animals, including humans Recognise that living things have changed over time and that fossils provide information about living things that inhabited the Earth millions of years ago Recognise that living things produce offspring of the same kind, but normally offspring vary and are not identical to their parents Identify how animals and plants are adapted to suit their environment in different ways and that adaptation may lead to evolution Recognise that light appears to travel in straight lines Use the idea that light travels in straight lines to explain that objects are seen because they give out or reflect light into the eye Explain that we see things because light travels from light sources to our eyes or from light sources to objects and then to our eyes Use the idea that light travels in straight lines to explain why shadows have the same shape as the objects that cast them Associate the brightness of a lamp or the volume of a buzzer with the number and voltage of cells used in the circuit Compare and give reasons for variations in how components function, including the brightness of bulbs, the loudness of buzzers and the on / off position of switches Use recognised symbols when representing a simple circuit in a diagram

For over 20 years, the National Curriculum has been revised and over the next couple of years there are a number of changes to be put in place, including some changes that have already happened.

Five years after issuing a report warning that the United States was losing its competitive edge over other countries by not producing adequate numbers of scientists, engineers, and mathematicians, a national panel is back with a second report that finds that not much has changed.

And with recent changes in state law, it becomes possible over the next several years to double the number of charter school seats in Boston from the current 5,200.

Statistics published in December showed the number of GCSE grades changed after marking review last year increased by 52 per cent, with over 25,000 more changes than in 2016.