Not exact matches
Breeders cross varieties with a differing
number of chromosomes to produce a sterile fruit,
which has small, white, fully edible «seed coats» instead
of mature black seeds.
That's because D7 embryos —
which develop more slowly — are thought more likely to contain an abnormal
number of chromosomes (aneuploidy).
Perhaps because it is normal for human embryos to contain cells with the wrong
number of chromosomes,
which can cause them to self - destruct.
As women age, their eggs are more likely to have the wrong
number of chromosomes,
which can lead to miscarriages.
During periods
of high stress, he says, men produce less testosterone,
which can reduce the
number and quality
of the «male» sperm,
which carry a Y sex
chromosome.
Any deviation in these processes could lead to cells that do not have the proper
number of chromosomes,
which could accelerate tumor initiation and progression.
Results from the analysis confirmed previous findings
of some copy
number variants already associated with autism, but they also found a host
of other genes (SHANK2, SYNGAP1, DLGAP2 and the X
chromosome — linked DDX53 - PTCHD1 locus) in
which mutations seem to be linked to autism.
Venken first sought a vector that could handle large amounts
of DNA efficiently, settling on a bacterial artificial
chromosome,
which was designed a couple years ago and is known to maintain only a few copies
of the DNA (though it can produce a high
number of copies if it is induced).
As all school - children learn, cells divide using a process called mitosis,
which consists
of a
number of phases during
which duplicate copies
of the cell's DNA - containing
chromosomes are separated into two distinct cells.
That is because something about the aging process upsets the process
of meiosis, the nuclear division
of the ovum or sperm in
which chromosomes are reduced to half their original
number.
But Greg Fitzharris at the University
of Montreal in Canada and his team have now identified another way in
which cells can be left with the wrong
number of chromosomes.
Failure has often struck at the stage
of meiosis, a type
of cell division during
which paired
chromosomes swap DNA and the
number of chromosomes per cell is halved.
Aneuploidy is a condition in
which cells contain an abnormal
number of chromosomes, and is known to be the cause
of many types
of cancer and genetic disorders, including Down Syndrome.
In other words, alterations in the
number of chromosomes,
which can lead to a tumour process,» explains Montoya.
Their work,
which is published in Nature Ecology and Evolution, shows for the first time the existence in Leishmania
of a relation between changes in
chromosome copy
number and the selection
of new alleles important for parasite survival.
Rather gene dosage,
which depends on the
number of chromosome copies, is responsible for this: «If the
chromosome is multiplied, then more copies
of the same gene will be transcribed.
Most researchers believed that the Y
chromosome of cattle would be similar to the Y
chromosome of other mammals,
which does not have a large
number of genes and is considered mostly transcriptionally inactive, Liu said.
But to complete their maturation into sperm,
which have half the
number of chromosomes of nongerm cells, these PGC - like cells were transplanted back into mouse testes.
Both
of the new studies found that copy
number events involving either duplication or deletion
of the 25 to 30
chromosome - 16 genes — several
of which are known to play a role in the developing brain — appear to cause autism.
When geographical barriers — such as rising sea levels or retracting ice floes — separate populations, they may develop genetic, physiological, or behavioral differences; changes in
chromosome structure or
number; differently shaped genitalia; or incompatible mating times and rituals — any
of which can prevent successful reproduction.
A. Bar heights indicate the degree to
which each
chromosome contains an unexpectedly high
number of differentially methylated promoters.