On any given day, a # 1 bestseller in an ebook store might be selling twice the number copies as the # 5 - ranked title on that day, and triple or quadruple
the number of copies as the # 10 bestseller.
If going with a larger print run on offset lithographic presses makes sense because you'll need a large
number of copies as cost - effectively as possible, then we'll get your books into production in our offset plant.
In the past, indie publishers were typically forced to order a required
number of copies as a first printing, and figure out how to sell and distribute them later.
Not exact matches
Haik and Moretti say Mic is also tracking time spent on a page along with other metrics such
as repeat visitors, scroll depth (how far a reader gets into a story before they click away), and the
number of times content is
copied and pasted into a post, tweet, or email.
If the box's channels don't have your entertainment options covered, you can easily
copy video onto a USB stick and plug it in, with a
number of channels / apps such
as Plex also helping with streaming from a computer.
While there are certainly a stable
of proven sale strategies that are widely applicable to growing your startup regardless
of the industry you're in, it's not quite
as simple
as copying, pasting, and kicking back to watch your
numbers soar.
While some rights holders have argued that the standard for a substantial is very low (the National Post recently argued in a case that «even the reproduction
of a small
number of words in a newspaper article can be an impermissible reproduction»), the Copyright Board says that its preliminary view is that «
copying of a few pages or a small percentage from a book that is not a collection
of short works, such
as poems, is not substantial.»
If you would like to revoke your consent to householding and in the future receive your own Notice
of Internet Availability
of Proxy Materials (or your own set
of proxy materials,
as applicable), or if your household is currently receiving multiple
copies of the same items and you would like in the future to receive only a single
copy at your address, please contact Householding Department by mail at 51 Mercedes Way, Edgewood, New York 11717, or by calling 1-800-542-1061, and indicate your name, the name
of each
of your brokerage firms or banks where your shares are held, and your account
numbers.
Also, we'll be covering a
number of other A / B testing topics
as part
of this series, including website
copy, email campaigns, pay - per - click advertising, and SEO landing pages.
To get a phone
number, it's simple to set up a local SIM card,
as long
as you have a
copy of your passport and address.
You should also have a
copy of your drivers license handy,
as well
as the social security
numbers of everyone whose name will be listed on the mortgage.
In this video I'm going to show you a great way to get better keywords out
of the Google Adwords Keyword tool if you haven't seen the previous video you'll want to watch that video where I show you how to get better search volume
numbers from both google adwords
as well
as some other sources to get better estimates for the amount
of times that keyword is searched each month i'll put a link in the video here so that you can click that video if you haven't seen that yet let's get started now if you want better results from the Google Adwords Keyword planner you have to work a little differently than everyone else so most people come to the Google Adwords Keyword planner and they simply click on this search for new keywords using a phrase, website, or category and then they just paste a bunch
of keywords into this text box so let's say
as an example that these were our starting keywords ok so let's say we have the keywords «fishing tips» «fishing tackle» «fishing for bass» «fishing rod» and «fishing reel» what most people do is that they would simply come here and they would
copy this they would paste it into this field and they would hit Search and they would get back their results and that's fine but one little tip that will help you get much better results is only paste in one key word at a time so instead
of pasting all these in just paste in the single keyword «fishing tips» and then proceed from there to pull that those results up and you'll get this back if you click right here you can download the ideas you'll notice they're 701 here listed so if we download these ideas will download them to a CSV file comma separated value file you can open that with notepad you can open it with excel open office when you're finished putting all your ideas and individually you will now have a bunch
of different common separate value files containing the keywords and the search volume I've already gone ahead and done that just to save time on the video but i want to show you what happens when you use this method versus just pasting in the keywords like most people do so here you'll see this column here represents these two columns here represent if we had pasted in all
of the keywords at once and click search at google adwords keyword tool is one that showed you and you'll see we have a total
of 706 results we got back when we did that this column this column here represents what happens when we paste one key word at a time and then download the file paste the second keyword download the file and then we just simply grab those terms and
copy them and you'll see now we have a total
of 1,915 keywords now what I've done with the highlighting here is to show you anything that's not highlighted in this column is a keyword we would not have gotten back had we pasted in all the keywords at once you can see there's lots and lots
of keywords here we would not have seen know your competitors and the company's you're competing against they're using probably the simple method just pasting a bunch
of keywords sitting search and then looking through those terms to find their terms if you will take the extra few minutes it takes doesn't take long to simply go in and paste one key word at a time you will get back a ton
of great keywords that others aren't seeing because they're using this other method and in actuality when I ran the
numbers there's a total
of 3.8 million searches represented by these keywords here that you would miss if you simply just
copied and pasted those five terms and hit search the Google Adwords Keyword planner once you've used the google keyword planner to find lots
of new keyword ideas what do you do with all those keywords the biggest problem is that you can there are so many keyword tools out there you can get hundreds
of thousands
of keywords by spending a day using the different keyword tools but what you do with all that information the answer is a cool tool called keyword grouper pro and Keyword Grouper Pro is completely free there's not even an opt in you just simply download the tool now at the top
of this video there's a link if you click that i'll show you exactly how to use keyword grouper pro doesn't matter where you got your keywords from i'm going to show you how to take those keywords group them into tight groups and then you can set up your campaigns and know exactly which groups represent buyers and once you know where the buyers are at you can simply focus your marketing in that area to make more profit in your business
I have a
number of copies of these before me
as I write.
I believe because the evidence is continuing to back the Bible and
as I said earlier the
number of ancient
copies of the Bible is inscribe, way over a hundred, and they all match, although there are sometimes variations, they agree with one another.
I'm pretty sure that my
copy will have the same
number of bookmarks
as yours!
Once your list is complete, email us your name and telephone
number as well
as a photograph or photo -
copy of your military or first responder ID.
Copies of texts supplied by Matt Seaton and Chris Sharpe,
as well
as photos
of pictures and winners from the «Images
of Fathers» exhibition (in print and email format) are available from Fathers Direct and from the Lloyds TSB Foundation (contact
numbers attached).
So what we did was once the plates were dry was draw a circle — some I did and some J did —
as I wanted us to look at
numbers and symmetry but without J realising it so I drew a line down the middle
of the plate — on one side I drew either 1, 2, 3, 4 or 5 circles and then J
copied them on the other side
of the line he did it really well.
So his campaign released a television ad
as rudimentary
as any broadcast that political season, featuring a
number of prominent politicians — City Council Speaker Christine Quinn, West Side Congressman Jerry Nadler, Manhattan borough president Scott Stringer — carrying a folded
copy of The New York Times, while reading from its endorsement
of his candidacy.
It is also crucial that such information is available in hard
copy format
as well
as online to help the substantial
numbers of taxpayers who are either digitally excluded or find it difficult to engage with government online.»
But there is widespread concern within the industry about the quality
of journalism being published online, with «clickbait» often ruling the roost and the performance
of reporters being judged solely on visitor
numbers as opposed to the standard
of their
copy.
Applicants must bring a
copy of a recent utility bill
as well
as documentation verifying income, rent, and the date -
of - birth and social security
number of each household member.
They made these clones by a process called automatic parthenogenesis: The egg is formed normally (with half the species» usual
number of chromosomes), then fertilized by the «polar body,» a cell that is created during oogenesis and contains the same gene
copies as the egg, resulting in the shark having half the genetic variation
of its mother.
Extra bases are easily added or lost when the DNA is
copied, so the
number of repeats in each
of these stretches, known
as microsatellites, varies widely from one individual to another.
These primers allow the DNA to be
copied (in a process known
as PCR), to build up a sufficient
number of copies that can be read by a DNA sequencer.
A strong, male - biased mutation spectrum was also measured, wherein three - quarters
of mutations occurred in sperm thorough spermatogenesis,
as well
as new structural alterations, such
as changes in gene conversion and
copy number.
Both the hunter - gatherers
as well
as the early farmers displayed high
copy numbers of amylase genes in their genomes, suggesting that both populations had already adapted to a starch - rich diet.
Using clinical, genetic, and gene expression data
as filters to distinguish genes whose
copy number alteration causes cancer from those for whom
copy number changes are incidental, the team whittled down their list from 14,000 to a more manageable
number, each
of which they systematically tested using genetic experiments in animals.
By studying rare «
copy number variations,» which are individual errant insertions or deletions
of DNA segments (each
of which occur in less than one percent
of the population), researchers discovered a new cluster
of genes that are affected in some autistic individuals
as well
as a
number of mutations that were present in autistic children but not their parents.
He notes that because
of the boggling
number of potential factors, such
as copy number variations, point mutations and epigenetic (inherited mutation) factors involved in autism, it will be important to find common pathways «because the mechanisms interrupting those pathways might be different among individuals.»
As all school - children learn, cells divide using a process called mitosis, which consists
of a
number of phases during which duplicate
copies of the cell's DNA - containing chromosomes are separated into two distinct cells.
«We also showed that
as the
number of mutant KRAS
copies increases, the tumor's aggressiveness and ability to metastasize also increases.»
As with most cancers, triple - negative breast cancer (TNBC) cells have abnormal amounts
of chromosomes or DNA
copy number aberrations (CNAs) in their genomes.
«Our preliminary data in cancers such
as prostate, colon, liver and lung suggest a punctuated model
of copy number evolution is also likely to be operative in other solid cancers,» said Navin.
This type
of disorder is also known
as a
copy number variation (CNV).
Mark Daly, an assistant professor
of medicine at Harvard University Medical School and MGH
as well
as co-author
of the NEJM study, notes that «It is extremely unusual to see these spontaneous deletions and duplications in a region that's usually a
copy number — stable region.
«The general approach
of looking at
copy number variation
as the cause for genetic disease has probably taken one
of those exponential — it's probably hyper --- exponential leaps,» he says.
Citing the growing body
of evidence
of links between
copy number variations and diseases such
as autism, an international science consortium announced yesterday that it plans to sequence the genomes
of 1,000 people from around the world in an attempt to flush out genetic suspects.
(Chromosome 16 is the second instance
of a
copy number variation to be fingered
as a causative mutation
of the condition.
There are a
number of viruses that have a similar way
of copying themselves — a process that reverses the normal flow
of information in cells, which is where the term «retro» comes from — and their central machinery for replication may be a bridge from the original life - forms on this planet to what we know
as life today.
Using a specific work flow, they assessed both the coding and noncoding regions
of the human genome, including the evaluation
of highly polymorphic SNPs, structural and
copy number variations,
as well
as 69 control genomes sequenced by the same procedures.
This murine model system offers a superior source
of immortalized cell populations
as many
of the difficulties associated with the in vitro transfection process are eliminated (e.g., initial requirement for many cells, different sites
of gene integration, multiple
copy number; Ref.
However, such CRISPR screens are sensitive to a phenomenon called the
copy number effect, where genes that have been repeatedly duplicated within a cell (
as commonly happens in cancer cells) can be flagged
as essential regardless
of whether they are or not.
The patterns
of somatic
copy number changes,
as assessed by high - density SNP array, suggest widespread segmental CNA instability:
The development
of high - throughput screening methods such
as array - based comparative genome hybridization (array CGH) allows screening
of the human genome for
copy -
number changes.
Anecdotal data on an increasing
number of genes support this view: Drosophila has one
copy each
of the Ras, Raf and Notch genes,
as well
as of the genes
of the Hox cluster, while vertebrates have three or more
of each
of these genes.
As an example, skeletal malformations and dysplasias, often detected through routine prenatal ultrasound examination, constitute a phenotypic finding in more than 300 syndromic and non-syndromic disorders and their genetic etiology may be due to a wide variety
of genetic aberrations, ranging from
copy number variations to single gene mutations.
This is to accommodate small variants that occur at sites
of copy number variation
as well
as in samples that are not pure: for example, due to tumor heterogeneity or sample mosaicism.
Developing novel tools to quantify gene expression in single cells
As it has become increasingly apparent that gene expression in individual cells deviates significantly from the average behavior
of cell populations, new methods that provide accurate integer counts
of mRNA
copy numbers in individual cells are needed.
Our results establish gene conversion
as a previously under - appreciated mechanism
of generating
copy number changes in humans and reveal the exceptionally large size
of the conversion events that can occur.