Sentences with phrase «number of drugs targeting»

«Importantly, while the overall number of new investigational cardiovascular drugs has declined, we also found a relative growth in the number of drugs targeting novel biological pathways,» Kesselheim said.

The increasing number of drugs targeting specific proteins implicated in tumourigenesis and the commercial promotion of relatively affordable genome - wide analyses has led to an increasing expectation among patients with cancer that they can now receive effective personalised treatment based on the often complex genomic signature of their tumour.

Friedman notes that, even with the increasing number of drugs targeting specific molecular abnormalities that drive tumor growth, most patients are only treated with one such drug at a time.

Researchers in Sweden have just identified a number of drug targets that can be used in the development of new efficient treatment strategies with minimum side effects.

Not exact matches

She says a number of experimental drugs now in clinical trials are designed to target serotonin in other ways in the brain, and may have better success than the SSRIs.

From accelerating the identification and validation of novel therapeutic targets, to creating better animal models of human diseases in a shorter time frame, to reducing the number of failed products, Crispr looks set to shave millions off R&D costs and boost drug discovery, she says.

«The number of protein functions that are currently targeted by drugs is incredibly small compared to the total number of protein interactions that could be targeted for therapeutic benefit,» says Geoffrey Wahl, a professor in Salk's Gene Expression Laboratory.

It is triggered by the immune system, and new insights into immune processes have thrown up a number of exciting drug targets.

Structure - based drug design, in which the physical structure of a targeted protein is used to help identify compounds that will interact with it, has already been used to generate therapeutic agents for a number of infectious and metabolic diseases.

Unsurprisingly, then, MET is the target of a number of drug development efforts, which have in common the aim of blocking MET's activation.

A number of drugs that target the p53 pathway, like Nutlin - 3, are currently in clinical development.

In an effort to expand the number of cancer gene mutations that can be specifically targeted with personalized therapies, researchers at University of California San Diego School of Medicine and Moores Cancer Center looked for combinations of mutated genes and drugs that together kill cancer cells.

Further, a significant percentage of these complex mutations are found in well - known cancer genes that could be targeted by existing drugs, potentially expanding the number of cancer patients who may benefit.

Mardinoglu says the team's network modeling approach, which relied on data from the Sweden - based Human Protein Atlas project and The Genotype - Tissue Expression (GTEx) project consortia, can be used in the identification of drug targets and eventually in the development of efficient strategies for treating a number of chronic liver diseases.

However, the reality is that nanocarriers may not always reach their intended target in sufficient numbers because of a constraint on their ability to transit through the blood vessel wall at the tumor site, leading the encapsulated drugs to be diverted or lost before they can deliver their payload.

Thus, the glutamate pathway has become the target of a number of new drug therapies.

A small number of these mutations have been found previously in other cancers, and drugs have been developed to target these mutations,» said lead author Raphael Bueno, MD, chief of the Division of Thoracic Surgery at BWH and co-director of the BWH Lung Center.

Although a small number of repurposed and new drugs have recently become available to treat drug - resistant TB (including bedaquiline, delamanid, and linezolid), the authors warn that without accurate diagnostic tests to deliver individually targeted treatments, clear prescription guidelines on appropriate use and improved control efforts to prevent transmission, optimal dosing and administration, and well - functioning health care systems, the effectiveness of the drugs could be rapidly lost.

To narrow down the number of chemical compounds that could be potential drug candidates, scientists utilize computer models that can predict how a particular chemical compound might interact with a biological target of interest — for example, a key protein that might be involved with a disease process.

He thinks a number of cancer cell subsets are never really affected by most targeted anticancer drugs currently used.

Ahead of us now is the major task of exploring the potential of new drug targets, so that hopefully we can prevent the number of people with untreatable infections from escalating further,» says Professor Anders Miki Bojesen, who coordinates the UC - Care research activities at the Department of Veterinary Clinical and Animal Sciences.

Research led by scientists at the University of Birmingham shows more precisely how G protein - coupled receptors, which are the key target of a large number of drugs, work.

«We are working to increase our understanding of Alzheimer's disease all the time, and there are already a number of drugs in clinical testing that are targeted against amyloid.

It can be used in the identification of drug targets and eventually in the development of efficient strategies for treating a number of chronic liver diseases.

Lung cancer treatment is an evolving field of science, currently there are several pathways under investigation as a possible treatment target.1 - 3 Targeted treatment is currently considered to be more efficient compared to the non-specific cytotoxic drugs, however; the small number of patients identified with mutations, limit the application of these drugs.

Vescor, advised by its scientific founders White and Kimmelman, whose research has shown inhibition of autophagy can dramatically impact tumor growth in pre-clinical models, will develop small molecule inhibitors of a number of protein targets at critical nodes of the autophagy cascade, perform investigational new drug (IND) enabling studies, and move these into clinical development.

In the search for compounds that might alter a protein's behavior or function — such as that of alpha - synuclein — drug companies often rely on so - called target - based screens that test the effect large numbers of compounds have on the protein in question in rapid, automated fashion.

Horizontal transfer of genes of bacterial origin has contributed to some of the metabolic differences in these parasites, and a number of novel potential drug targets have been identified.

The study includes a detailed picture of the proteins that are linked to cancer, the number of proteins present in the bloodstream, and the targets for all approved drugs on the market.

Fortunately, there are a number of targeted drugs in phase III clinical trials.

They expect that many genes will overlap and affect the same cellular process, which will help them narrow down the number of potential drug targets.

We are applying it to evaluate large number of potential drug targets in a faster and more systematic way than before and to select the best ones to work on.

Knowledge of these mutations could potentially identify a greater number of patients with treatable mutations because many potent cancer drugs that target these mutations already exist.

In fact, a predominant number of current drugs target the GPCR signaling.

To understand the selection mechanism behind mutations, network - based studies were used to estimate the importance of a mutated protein compared to non-mutated ones in signalling and protein — protein interaction networks.10, 11,12,13 Proteins mutated in cancer were found having a high number of interacting partners (i.e., a high degree of connectivity), which indicates high local importance.10 Mutated proteins are also often found in the centre of the network, in key global positions, as quantified by the number of shortest paths passing through them if all proteins are connected with each other (i.e., they have high betweenness centrality; hereafter called betweenness).11, 12 Mutated proteins also have high clustering coefficients, which means their neighbours are also neighbours of each other.10, 13 Moreover, neighbourhood analysis of mutated proteins have been previously successfully used to predict novel cancer - related genes.14, 15 However, to the best of our knowledge, no study has concentrated particularly on the topological importance of first neighbours of mutated proteins in cancer, and their usefulness as drug targets themselves.

This led to the development of a number of drugs that targeted and blocked specific receptors in this pathway.

Police will soon be launching their national campaign which will target drink drivers, as the number of drink and drug driving offences increases hugely around the Christmas time.

Goals: Formalise and rationalise the collection of data in the region; reduce by half the number of Aboriginal and Torres Strait Islander children on long - term care and protection orders by 2008; Achieve a target of 90 % of Aboriginal and Torres Strait Islander children enrolled in pre-primary and kindergarten programs by 2008; reduction in truancy rates; achieve 20 % increase in participation rates in sport and recreation; reduce number of alcohol related and drug related incidents in community.