Under the Obama administration,
the number of embryonic stem cell lines available for federally funded research had more than tripled, but no money was going toward the creation of any cell lines (a process that destroys the embryo).
Collins and others argue not just for a permanent removal of the injunction to resume research with confidence, but also for an extension of
the number of embryonic stem cell lines available to federally funded researchers.
Not exact matches
In August
of last year, President Bush approved the use
of federal funds to support research on a limited
number of existing human
embryonic stem cell lines.
He decreed that the case brought by researchers Drs James Sherley and Theresa Deisher, along with a
number of Christian groups including the Christian Medical Association, should be heard; and ordered an injunction temporarily blocking federal funding allocated for human -
embryonic -
stem -
cell research.
Congressional supporters
of stem cell research have re-introduced legislation to codify President Barack Obama's 2009 executive order lifting restrictions on the
number of human
embryonic stem cell lines available to federally funded researchers.
In addition, where
cells derived from
embryonic stem cells are great at proliferating — a potentially critical feature if one wants to grow sufficient
numbers of cells for clinical use — ones from the iPS lines were much feebler.
He has also been an inveterate foe
of abortion, a position that informed his repeated votes against expanding the
number of human
embryonic stem cell lines available to NIH - funded researchers during the George W. Bush administration.
But a
number of the invited speakers, including Alan Trounson, president
of the California Institute for Regenerative Medicine in San Francisco, and keynote speaker George Daley, a
stem -
cell scientist at Children's Hospital Boston in Massachusetts, are involved in research using human
embryonic stem cells, which the Catholic Church considers unethical.
«We can work with any
embryonic stem cell line from any source and are not restricted to working with the very small
number of federally approved lines as is the case for researchers in the United States,» says Minger.
But if homologous recombination could be worked out in human (
embryonic)
stem cells, then cardiomyocytes with mutations in ion channels could be derived, as well as a large
number of other very useful disease models
of other tissues.
They used the gene editing technology CRISPR to engineer a series
of human
embryonic stem cell lines, which were identical apart from the
number of DNA repeats that occurred at the ends
of their HTT genes.
Earlier this year, scientists at University
of California, Los Angeles, and Advanced
Cell Technology
of Marlborough, Massachusetts, reported in The Lancet about the safe and successful use
of RPE
cells derived from human
embryonic stem cells, rather than iPS
cells, to treat a different type
of AMD in a limited
number of human patients.
Pluripotency distinguishes
embryonic stem cells from adult
stem cells found in adults; while
embryonic stem cells can generate all
cell types in the body, adult
stem cells are multipotent and can produce only a limited
number of cell types.
This allows
embryonic stem cells to be employed as useful tools for both research and regenerative medicine, because they can produce limitless
numbers of themselves for continued research or clinical use.
Derivation
of pluripotent
stem cells, either
of embryonic origin or following genetic reprogramming, has opened the path for an alternative source for epidermal
cell therapy as these
cells are both immortal and pluripotent, theoretically capable
of providing any requested
number of cells of any desired phenotype.
Mouse
embryonic stem cells stained for key pluripotency markersGRAZIANO MARTELLO Combining computer science algorithms with biological data has enabled researchers to create a model
of the minimal
number of factors necessary for mouse
embryonic stem cells (ESCs) to self - renew in culture.
In the meantime a large
number of federally funded human
embryonic stem cell projects have been placed on hold, and even more are potentially at risk.
Not so long ago, human
embryonic stem cell (hESC) research and SCNT were being hailed as the future
of regenerative medicine, capable
of generating cures and therapies for any
number of diseases and conditions.
Embryonic stem cells (ESCs) represent a source for the large
numbers of modified EPCs required to therapeutically inhibit tumorigenesis [3], although patient - specific induced pluripotent
stem cells (iPSCs) represent a more attractive option.
Forced aggregation
of defined
numbers of human
embryonic stem cells into embryoid bodies fosters robust, reproducible hematopoietic differentiation.
Stem cell researchers from UCLA used a high resolution technique to examine the genome, or total DNA content, of a pair of human embryonic stem cell lines and found that while both lines could form neurons, the lines had differences in the numbers of certain genes that could control such things as individual traits and disease susceptibil
Stem cell researchers from UCLA used a high resolution technique to examine the genome, or total DNA content,
of a pair
of human
embryonic stem cell lines and found that while both lines could form neurons, the lines had differences in the numbers of certain genes that could control such things as individual traits and disease susceptibil
stem cell lines and found that while both lines could form neurons, the lines had differences in the
numbers of certain genes that could control such things as individual traits and disease susceptibility.
In this study, Teitell and his team sought to determine copy
number variants (CNVs), or differences in the
numbers of certain genes, in two
embryonic stem cell lines.
The use
of human
embryonic stem cells, as opposed to patient blood, as the starting material for AST - VAC2 provides a scalable system for the production
of a large
number of vaccine doses in a single lot, reducing manufacturing costs, enabling «off - the - shelf» availability, and ensuring product consistency.
«Basically, this study shows that the genetic makeup
of individual human
embryonic stem cell lines is unique in the
numbers of copies
of certain genes that may control traits and things like disease susceptibility,» said Teitell, who also is an associate professor
of pathology and laboratory medicine and a researcher at UCLA's Jonsson Comprehensive Cancer Center.
In the last decade, the
number of human
embryonic stem cells (ESC) and human induced pluripotent
stem cell (iPSC) lines has dramatically increased.
Unlike
embryonic stem cells from earlier in development, fetal
stem cells from umbilical cord blood are multipotent - they can develop into a limited
number of cell types.
A
number of recent articles, however, have reported that hiPSCs are, in fact, notably distinct from human
embryonic stem cells in terms
of their gene expression, epigenetic profile, proliferative capacity and the susceptibility
of their differentiated progeny to cellular senescence and apoptosis [3 — 6].
In April 2004, more than 200 members
of the U.S. House
of Representatives sent President Bush a letter, asking him to increase the
number of human
embryonic stem cell lines that should be eligible for public funding.
The results have been organized in an interactive, open - access database with a
number of novel features and search tools to promote studies into the biological properties
of embryonic stem cells.
In April
of 2004, a letter bearing 206 signatures
of Members
of the United States House
of Representatives was sent to President George Bush, asking him to increase the
number of human
embryonic stem cell lines that should be eligible for public funding.