Sentences with phrase «number of genes involved»

Since its genome was sequenced in 2002, scientists have identified a number of genes involved in how the parasite functions inside its host to cause malaria.

In particular, the protein enhances the expression of a well - characterized oncogene called MYC, which in turn regulates a large number of genes involved in cell proliferation.

This list is fascinating as it includes a number of genes involved in the development of muscle and bones.

A large number of genes involved in nervous system development and function were also deregulated.

Not exact matches

Even with the phenotype, perhaps there is a «trade off involved» in that the same underlying genetic sub-scripts serve other purposes, or perhaps the sheer numbers of gene - hormonal permutations mean it will always manifest itself due to pure statistics.

For instance, one admits that in much of evolution (probably all above the bacteria), evolutionary changes involve enormous numbers of genes, rather than a selection of one or two particular genes (although that occurs in a few instances, possibly, for instance, in industrial melanism).

PRMT1 is involved in a number of genetic processes including gene transcription, DNA repair and signaling.

A number of individual genes have been linked to suicide, such as those involved in the brain's response to mood - lifting serotonin, and a signalling molecule called brain - derived neurotrophic factor (BDNF), which regulates the brain's response to stress.

Comparisons of the Neandertal genome to the genomes of five present - day humans from different parts of the world identify a number of genomic regions that may have been affected by positive selection in ancestral modern humans, including genes involved in metabolism and in cognitive and skeletal development.

This study showed the two subtypes have different genetic origins and involve a dramatically different number of chromosomal rearrangements, mutations and other gene variations.

The researchers used their new method to identify a number of previously unknown genes that are involved in B - cell development.

A number of these genes are involved in cancer and developmental abnormalities, he says, and «they may explain how some of these conditions came to be.»

For the manatee, walrus, dolphin, and killer whale, the return to the sea involved many evolutionary trade - offs amongst hundreds of genes: a general loss of the number of sensory genes for smell and taste, new functions for genes forming skin and connective tissue, and genes involved in muscle structure and metabolism.

Three simultaneous reports involving more than 32,000 participants uncovered four new diabetes - associated gene variants, bringing to 10 the number of known non-Mendelian genetic risk factors for type 2 diabetes.

A comprehensive genomic analysis of Wilms tumor — the most common kidney cancer in children — found genetic mutations involving a large number of genes that fall into two major categories.

By working closely with the KhoeSan, a group of populations indigenous to southern Africa, the researchers have found that the genetics of skin pigmentation become progressively complex as populations reside closer to the equator, with an increasing number of genes — known and unknown — involved, each making a smaller overall contribution.

«We were able to show that a significant number of these adenomas carry a mutation in a gene that is involved in controlling cell proliferation and differentiation,» Calebiro further explained.

«We observed that a large number of genes were involved in pathways related to wound healing, immunity, and metabolism, and this is consistent with the idea that the earliest stages of domestication may involve adapting to highly crowded conditions,» said Mark Christie, lead author of the study.

«We have also found a number of gene families that seem to be involved in the parasitism of insects by worms and we are excited to continue studying these in future experiments.»

Over the years, a number of groups have identified genes which might be involved with bipolar disorder.

A new genetic analysis reveals that our brawny cousins had a number of distinct genes involved in the buildup of certain types of fat in their brains and other tissues — a trait shared by today's Europeans, but not Asians.

This gene, along with a number of other genes encoding proteins involved in nickel homeostasis, has been acquired a long time ago by the bacterium via horizontal gene transfer.

Both of the new studies found that copy number events involving either duplication or deletion of the 25 to 30 chromosome - 16 genes — several of which are known to play a role in the developing brain — appear to cause autism.

A study published online 10 October in Nature Genetics provides the strongest evidence yet for the starting gun theory by showing that mutations in a gene involved in ensuring proper numbers of chromosomes result in childhood cancer.

They found over 700 genes which, when inhibited, brought down ENaC activity, including a number of genes no - one knew were involved in the process.

The researchers also found that these copy number variants occurred more frequently in genes involved in the function of synapses, the connections between brain cells that transmit chemical messages.

With this approach the authors report a number of unique RP mutations, a previously undescribed disease gene called NEK2 that involves the retinal photoreceptors, and structural DNA rearrangements originating in introns.

Reuters reports that «the activity of disease - preventing genes increased while a number of disease - promoting genes, including those involved in prostate cancer and breast cancer, shut down, according to the study published in the journal Proceedings of the National Academy of Sciences.»

Study coauthors Rammohan Rao of the Buck Institute for Research on Aging and Dale Bredesen of the Buck Institute and UCLA «have provided evidence for a novel — in fact, radical — idea: that ApoE somehow gains access to the nucleosol and acts as a conventional transcription factor, influencing the expression of a large number of genes,» Steven Barger, who studies neurodegenerative disease at the University of Arkansas for Medical Sciences and was not involved in the study, wrote in an email to The Scientist.

At any given instant it can be argued that the cell is in a «state» defined by its components — their concentrations and locations, the interactions between components — that are modulated in space and time, and the complex circuitry — that involves a large number of interacting networks and a snapshot of the dynamical processes — such as gene expression, cell cycle, transport of components, etc..

Similarly, other genes involved together with DHCR7 in the cholesterol biosynthesis pathway, are also associated with a number of genetic disorders / syndromes (e.g., Antley - Bixler syndrome — POR gene), presenting with several common prenatal clinical manifestations (Porter & Herman, 2011).

Called RIDL (for «Release of Insects with Dominant Lethality»), it involves releasing large numbers of male mosquitoes with their genes adjusted so that when they mate with wild females, the offspring don't survive.

However, they were not designed to delineate regions of the genome resisting introgression nor investigate the frequency and types of genes involved in genetic incompatibilities, because they were based on a relatively small number of loci (less than 50) and the sampling of the genome was non-random (e.g. overrepresentation of the X-chromosome or regions near centromeres).

Quantitative analysis of bristle number in Drosophila mutants identifies genes involved in neural development.

By analyzing genome sequence data from human populations, including 1269 individuals from sub-Saharan Africa, we identify a diverse array of large copy number variants affecting the host invasion receptor genes GYPA and GYPB We find that a nearby association with severe malaria is explained by a complex structural rearrangement involving the loss of GYPB and gain of two GYPB - A hybrid genes, which encode a serologically distinct blood group antigen known as Dantu.

Figure 7 depicts a stationary view of the KEGG pathways for «Cell Cycle» and «Apoptosis» at three time points; it appears that ES cells (day 0) have higher numbers of expressed genes involved in cell cycle (rectangles in red color) compared to differentiated cells (day 10).