Sentences with phrase «number of long periods»

Given the small number of long periods without one, I don't actually think they are of any signifigance.

Not exact matches

And much of the reason its creators felt confident enough to invest all that time, money, and effort — given the small number of patients who might eventually use the medicine — can be traced to the Orphan Drug Act, a 1983 federal law that gave those who develop meds for uncommon diseases longer periods of marketing exclusivity and other financial incentives.

Our decision to select a decade - long period also limits the number of companies we'll study.

If so, you'll run a small number of commercials over a long period of time.

Actual results, including with respect to our targets and prospects, could differ materially due to a number of factors, including the risk that we may not obtain sufficient orders to achieve our targeted revenues; price competition in key markets; the risk that we or our channel partners are not able to develop and expand customer bases and accurately anticipate demand from end customers, which can result in increased inventory and reduced orders as we experience wide fluctuations in supply and demand; the risk that our commercial Lighting Products results will continue to suffer if new issues arise regarding issues related to product quality for this business; the risk that we may experience production difficulties that preclude us from shipping sufficient quantities to meet customer orders or that result in higher production costs and lower margins; our ability to lower costs; the risk that our results will suffer if we are unable to balance fluctuations in customer demand and capacity, including bringing on additional capacity on a timely basis to meet customer demand; the risk that longer manufacturing lead times may cause customers to fulfill their orders with a competitor's products instead; the risk that the economic and political uncertainty caused by the proposed tariffs by the United States on Chinese goods, and any corresponding Chinese tariffs in response, may negatively impact demand for our products; product mix; risks associated with the ramp - up of production of our new products, and our entry into new business channels different from those in which we have historically operated; the risk that customers do not maintain their favorable perception of our brand and products, resulting in lower demand for our products; the risk that our products fail to perform or fail to meet customer requirements or expectations, resulting in significant additional costs, including costs associated with warranty returns or the potential recall of our products; ongoing uncertainty in global economic conditions, infrastructure development or customer demand that could negatively affect product demand, collectability of receivables and other related matters as consumers and businesses may defer purchases or payments, or default on payments; risks resulting from the concentration of our business among few customers, including the risk that customers may reduce or cancel orders or fail to honor purchase commitments; the risk that we are not able to enter into acceptable contractual arrangements with the significant customers of the acquired Infineon RF Power business or otherwise not fully realize anticipated benefits of the transaction; the risk that retail customers may alter promotional pricing, increase promotion of a competitor's products over our products or reduce their inventory levels, all of which could negatively affect product demand; the risk that our investments may experience periods of significant stock price volatility causing us to recognize fair value losses on our investment; the risk posed by managing an increasingly complex supply chain that has the ability to supply a sufficient quantity of raw materials, subsystems and finished products with the required specifications and quality; the risk we may be required to record a significant charge to earnings if our goodwill or amortizable assets become impaired; risks relating to confidential information theft or misuse, including through cyber-attacks or cyber intrusion; our ability to complete development and commercialization of products under development, such as our pipeline of Wolfspeed products, improved LED chips, LED components, and LED lighting products risks related to our multi-year warranty periods for LED lighting products; risks associated with acquisitions, divestitures, joint ventures or investments generally; the rapid development of new technology and competing products that may impair demand or render our products obsolete; the potential lack of customer acceptance for our products; risks associated with ongoing litigation; and other factors discussed in our filings with the Securities and Exchange Commission (SEC), including our report on Form 10 - K for the fiscal year ended June 25, 2017, and subsequent reports filed with the SEC.

Challenge number one was how hard it was to find a large number of research subjects working in similar jobs, who could divide into work - at - home and work - at - the - office cohorts, and who were willing to cooperate with the researchers over a long enough period of time.

Research has shown that sitting at a desk for long periods of time can lead to health problems, yet a surprising number of commercial workplaces still reserve their sit to stand desks for executives only, or offer them on a case basis to employees who request them.

At the point the growth began to slow, the multiple would contract, meaning that even if its earnings do grow 600 % in the next few years, if it becomes subject to the law of big numbers - that ever increasing amounts eventually forge their own anchor - the result would be a market capitalization substantially similar to today, leading to no increase in the stock price over a long period of time.

The bottom line: While higher volatility is here for the foreseeable future, the selloff has created a number of potential opportunities for investors with longer - term holding periods.

You can set the device to sound an alarm when the engine RPM exceeds a certain number, when idling longer than a certain period of time, when breaking a specified speed limit, when it senses dangerous driving on the part of the operator, when the seatbelt is not used and when reversing.

While BinaryMate hosts tools for a number of trade types, some of its best features are its options for high / low trades, 60 - second trades, and trades with longer periods of expiry, up through 1 year.

Moreover, a recent speech by Jamie McAndrews outlines a number of respects in which negative interest rates, if attempted on a widespread basis over a long period, could in fact be very disruptive, and in ways not likely to be expansionary for growth.

These numbers will likely be different for each franchisee, as you may decide to make more of a down payment (which would lower your payments), you may decide to finance your equipment over a longer period of time (which will also lower your payments), and you may have to pay a higher interest rate (which would increase your payments).

«Each period, whether a day, a month, a year or longer, represents an infinite number of possible learning opportunities, revealing more and more about correlations, hedging, law, regulation, culture, sizing positions, trading versus holding, activism, bankruptcy law and practice, government action and political impacts on investing, organizational realities and growth, as well as the kind of personal characteristics that are required to do this job well.»

Ukwazi's growth is noticeable through the number of renewed contracts for longer periods and the new clients acquired in 2017; the company also has pipeline clients requesting additional services, mostly in the Southern Africa region.

Christians have also taken life and limb all over the planet in large numbers over long periods of time in order to forcibly convert people or enforce certain «morals».

Steve's point, however, regarding Christians having risked, and also lost, life and limb all over the planet in large numbers over long periods of time, in relief efforts, should be acknowledged.

It is not at all clear that fundamentalism provides an answer to the need for personal well - being of large numbers of people over a long period of time.

The long period of wilderness occupation is behind (how, again, are we to assess historically the obviously round number of «forty years,» Num.

Johnson (White Sox / Padres) and Cravy (Brewers) have both been up and down a number of times, but just haven't been able to be consistent enough to stick for long periods.

For the exquisite brand of football that Arsenal play, and retain possession of the ball for long periods in the game, Wenger's wizards don't score the number of goals you expect of them.

The combative midfielder has suffered a number of long - term injuries in the recent past and considering the physicality of the Premier League, there is a chance that he may spend long periods on the treatment table.

When you forget the names and the reps and just look at the numbers over a long period of time it tells a slightly different story.

I believe, a good exercise would be to take a sufficiently large sample size of players who played for Arsenal and some other club for a long period, say at least 3 - 4 years and compare their injury records in the two phases (number, frequency and nature of injuries incurred).

Nothing like one underachiever blowing smoke up the ass of another... we know that Ozil has some incredible technical gifts, but to be considered the best you have to bring more than just assists to the table... for me, a top player has to possess a more well - rounded game, which doesn't mean they need to be a beast on both ends of the pitch, but they must have the ability to take their game to another level when it matters most... although he amassed some record - like stats early on, it set the bar too high, so when people expected him to duplicate those numbers each year the pressure seemed to get the best of our soft - spoken star... obviously that's not an excuse for what has happened in the meantime, but it's important to make note of a few things: (1) his best year was a transition year for many of the traditionally dominant teams in the EPL, so that clearly made the numbers appear better than they actually were and (2) Wenger's system, or lack thereof, didn't do him any favours; by playing him out of position and by not acquiring world - class striker and / or right - side forward that would best fit an Ozil - centered offensive scheme certainly hurt his chances to repeat his earlier peformances, (3) the loss of Cazorla, who took a lot of pressure off Ozil in the midfield and was highly efficient when it came to getting him the ball in space, negatively impacted his effectiveness and (4) he likewise missed a good chunk of games and frankly never looked himself when he eventually returned to the field... overall the Ozil experiment has had mixed reviews and rightfully so, but I do have some empathy for the man because he has always carried himself the same way, whether for Real or the German National team, yet he has only suffered any lengthy down periods with Arsenal... to me that goes directly to this club's inability to surround him with the necessary players to succeed, especially for someone who is a pass first type of player; as such, this simply highlights our club's ineffective and antiquated transfer policies... frankly I'm disappointed in both Ozil and our management team for not stepping up when it counted because they had a chance to do something special, but they didn't have it in them... there is no one that better exemplifies our recent history than Ozil, brief moments of greatness undercut by long periods of disappointing play, only made worse by his mopey posturing like a younger slightly less awkward Wenger... what a terribly waste

The long fall and early spring typical of Columbia make possible a long season of outdoor sports, and one - hour periods guarantee the facilities will be used by a large number of students.

Whereas Eden Hazard's speed is most notable over a couple of yards, and Ramires is famed for his ability to keep running for long periods, Willian is somewhere between — making a high number of long, high - speed runs.

The veteran defender held his defence together for long periods, making a number of late runs and blocks to deny United.

After a long period of intense speculation, Liverpool finally lost their number ten on Saturday as news broke of Philippe Coutinho's move to Barcelona.

But few are well equipped to handle the strain of a hectic festive schedule than Tottenham's squad and with key personnel returning from long - term injuries at just the right time — Michael Dawson and Jermain Defoe both back from injury and involved in first - team affairs — this could be a defining period of the season for Spurs, a period where others may falter as they capitalise by defying the physical demands of Christmas fixtures by using strength in numbers.

«The goal here is to drive those numbers down through rules changes, culture changes, protocol changes, through greater observation and treatment over a longer term period of time.»

Placing a baby in a restricted position for long periods of time can cause a number of developmental delays.

According to a small group of researchers from Austria and the USA, large numbers of women having C - Sections over a long period of time may influence the evolution of our offspring.

To ensure your milk supply dries up gradually and to reduce the likelihood of engorgement, you'll want to reduce the number of feedings slowly over a longer period of time — 3 — 4 weeks is recommended.

«If reproduced over longer time periods and across the UK, as a whole, the additional numbers of patients presenting to [emergency care], with alcohol related problems could be very substantial.»

A low number of signatures over a long collection period would have a negative effect.

(2) The chairman, with the concurrence of the ranking minority member, or the Committee by motion, may permit an equal number of majority and minority members to question a witness for a specified, total period that is equal for each side and not longer than thirty minutes for each side.

The number of new residential solar - power installations on Long Island so far in 2017 has declined by more than 50 percent compared with the period in 2016 as national companies have fled the market or retuned their businesses.

Hayek, subsequently, had a long period in the intellectual wilderness, moving from the UK to the US, and was mostly ignored except by a small number of adherents.

First of all, when the debt ceiling resumes on February 7, 2014, it will no longer be 16.7 trillion; it will auto - adjust to take into account the borrowing done in the suspension period (although we will presumably still officially hit that higher number on February 7).

After a long period of Labour governments appointing new peers from 1997 to 2010, both Tories and Lib Dems are committed to increasing their numbers to balance Labour's advantage.

While the graph above shows a clear increase in the size of the chamber, the numbers become even more stark when looking only at life peerages over a longer period.

The number of private sector landlords who have registered with the Welsh Government's Rent Smart Wales scheme has barely struggled past ten per cent of those required to do so, with only five months left of the year long registration period, the Welsh Liberal Democrats Housing Spokesperson, Councillor Peter Black has revealed.

Dear CareerDoctor: I'm in a quandary.I'm a university lecturer in Chemistry, but after a long period of uncertainty within my institution, I recently found out that I am likely to be made redundant as funding levels and undergraduate numbers have dropped to apparently untenable levels.

We've had to deal with a large number of samples over a short period, working long hours and sometimes weekends to get results.»

Researchers also need to test a large number of battery cells over a long enough period of time under various physical conditions and temperatures to ensure that dendrites will never grow.

This means that more and more people work as postdocs for longer periods of time, on a series of short - term contracts, often in a number of different countries, before they will — or will not — transition to a group leader position.

The discovery, reported in the current issue of Nature Communications, logs a number of firsts: the first record of ancient tsunami activity found in a sea cave; the first record for such a long time period in the Indian Ocean; and the most pristine record of tsunamis anywhere in the world.

An APC - mimetic scaffold that was engineered to activate a specific type of CAR - T cell was able to generate higher numbers of the modified T cells over longer periods of culture than analogously designed expansion beads, and the resulting cells were similarly effective in killing the lymphoma cells in the mice.

«Our study has several distinct strengths compared to prior studies including the large number of participants, long - term follow - up, large number of cardiovascular events that were confirmed by medical record review, detailed information about diet and other cardiovascular disease risk factors, and repeated assessment of calcium supplement use over the 24 - year follow up period,» said Julie Paik, MD, MPH, BWH Channing Division of Network Medicine, Department of Medicine, lead study author.