Sentences with phrase «number of mouse genes»

2006 Shinya Yamanaka identifies and activates a small number of mouse genes in the cells of connective tissue, showing they can be reprogrammed to behave like immature stem cells.

Not exact matches

After determining the proper dosage of tamoxifen — an early trial resulted in a number of mouse deaths due to overactivation of Mecp2 — researchers settled on a four - week regimen of ramping up the gene's function.

Unless sufficient cohesin was present in the developing mouse brain, the researchers showed that the regulation of a number of genes was disrupted, leading to neuronal defects and increased anxiety.

The researchers were studying a well - established mouse model that forms a significant number of CCMs following the injection of a drug to induce gene deletion.

They found that the phages from antibiotic - treated mice carried significantly higher numbers of bacterial drug - resistance genes than they would have carried by chance.

As in the former case, after being treated with telomerase gene therapy «the telomeres in the peripheral blood in these mice also lengthened and the number of blood cells increased considerably,» write the authors.

Examining spinal cord cells under a microscope, the scientists noticed that the axons of mice missing the OPTN gene were swollen, inflamed and far fewer in number, compared with spinal cord cells obtained from mice with the OPTN gene.

The scientific community uses knockout mice to analyze basal phenotypes (the appearance of genetic characteristics) to analyze the function of such a large number of genes.

«When we compared the gene signature activity of glioblastoma cells from around 60 patients we found that a large number of patients could be divided into subgroups that showed a correlation between gene activity, tumor cell characteristics and cell of origin similar to the one we had seen in the mouse study.

The mice seem to develop normally when only one copy of the gene is removed, but microscopic inspection reveals a number of small «gaps,» or disorganized regions of tissue (on the scale of a few nanometers) on their aortas, the largest artery in their bodies.

After a week, the injected mice had more than twice the number of β cells as animals that didn't get the extra genes.

Gene expression divergence levels were obtained from [71] and were measured in terms of the number of commonly co-expressed genes between human and mouse one to one orthologs.

Further study of these mice showed that activating HIF - 1 in the cells appeared to turn on a number of genes that help these cells not only home to the ischemic limb, but to stay there once they arrive.

• Mouse whole genome scanning The unit offers microsatellite and SNP based Genome Scanning Services for gene identification projects, based on linkage analysis, offering coverage for a number of mouse strains (i.e. C57BL6, DBA2J, CBA, 129S6, 129P2), as well as bioinformatic analysis using suitable mouse genetic softMouse whole genome scanning The unit offers microsatellite and SNP based Genome Scanning Services for gene identification projects, based on linkage analysis, offering coverage for a number of mouse strains (i.e. C57BL6, DBA2J, CBA, 129S6, 129P2), as well as bioinformatic analysis using suitable mouse genetic softmouse strains (i.e. C57BL6, DBA2J, CBA, 129S6, 129P2), as well as bioinformatic analysis using suitable mouse genetic softmouse genetic software.

We have developed a new mouse model harboring a high number of MAIT cells that are also fluorescent by introgressing both a wild mouse gene and a ror (gt) GFP transgene.

A small number of mice were likely already carrying the genes that protect against heavy metals or infectious diseases.

Loss of Vascular Endothelial Growth Factor A (VEGFA) Isoforms in the Testes of Male Mice Causes Subfertility, Reduces Sperm Numbers, and Alters Expression of Genes That Regulate Undifferentiated Spermatogonia.

TRPV1: Gene knockout of the pain receptor TRPV1 is one of a number of methods of slowing aging and extending life in mice that appears to work through altered insulin signaling.

Researchers have determined that a gene present in mouse cells limits the number of times that a cell can divide.

If the genome projects verify the underlying octoploid nature of the human and mouse genomes, then the basic vertebrate gene number may be similar to that of the fly and worm, about 12,000 to 14,000 genes.

We conclude that the large number of mouse mutants and human de novo mutations may be due to the combination of the Chd7 gene being a large target and the fact that many heterozygous carriers of the mutations are viable individuals with a readily detectable phenotype.

The C / C mice are the homozygous line with the fewest number of human SMN2 genes that is viable.

The technical evaluation of projects may require the provision of additional data such as information on the genetic modification of your mutant mouse line if applicable (e.g. affected gene, MGI ID of the gene, type of mutation, ES - cell line used, genetic background (e.g. number of backcross generations), safety level, description of DNA modification, vector, remaining non-recipient DNA, donor organism), mutant phenotype (s), special housing or care requirements, current sanitary status, and intellectual property rights (who generated the mouse line, owner of the mouse line)

However, many E. coli strains that severely infected the mouse models were missing these virulence genes, and some of these strains outcompeted those with high numbers of the genes.

Interestingly, the number of immature ILC2s in bone marrow was comparable in normal and gene - deleted mice.

In the most recent assembly of the reference mouse genome (GRCm38) over 1,200 genes are annotated as coding for ORs and around 530 for VRs with a smaller number of TAAR and FPR genes.

To better illustrate gene expression profiles in mouse ES cells, we have organized the results in an interactive database with a number of features and tools.

Using the information provided in this article, calculate the number of mouse and human genes that are the same or similar.

In recent years, a number of genome - wide approaches have identified transcripts present in mouse and human ES cells or their differentiated derivatives using a variety of gene expression profiling methods [24], [27]--[32].

The Sanger Institute Gene Trap Resource (SIGTR) mouse ES cell line collection was developed to provide a powerful and cost effective approach using gene trapping to create large numbers of insertional mutations that are immediately accessible to molecular characterizatGene Trap Resource (SIGTR) mouse ES cell line collection was developed to provide a powerful and cost effective approach using gene trapping to create large numbers of insertional mutations that are immediately accessible to molecular characterizatgene trapping to create large numbers of insertional mutations that are immediately accessible to molecular characterization.

A gene screen revealed a number of genetic changes in the first (daughter) and third (great granddaughter) high - fat mice generations, including several linked to increased breast cancer in women, increased resistance to treatment, poor prognosis, and impaired anticancer immunity.

Genetic studies in humans and mice with idiopathic epilepsy have revealed a number of causative genes for specific forms of epilepsy 31.