Sentences with phrase «number of mouse models»

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«Indeed, in a second tumor model of metastatic breast cancer, we demonstrated that mice treated with the EphA2 - targeting paclitaxel conjugate presented nearly no lung metastases, while a large numbers of lesions were observed in both untreated mice and in mice treated with just paclitaxel.»

Using a flexible mouse model, her team set out to determine whether anything could be done to restore memory «after a significant number of neurons are lost in the brain.»

Daley's team showed that a brief, controlled pulse of Lin28 expression in their mouse model increased the numbers of nephrons in newborn mice.

The researchers were studying a well - established mouse model that forms a significant number of CCMs following the injection of a drug to induce gene deletion.

Shah next plans to rationally combine the toxin - secreting stem cells with a number of different therapeutic stem cells developed by his team to further enhance their positive results in mouse models of glioblastoma, the most common brain tumor in human adults.

2) The two repeated experiments analyze the source of POSTN expression in the lung and whether it affects the number / size of primary and secondary tumor formation in a spontaneous mouse model of breast cancer (MMTV - PyMT).

Mouse embryonic stem cells stained for key pluripotency markersGRAZIANO MARTELLO Combining computer science algorithms with biological data has enabled researchers to create a model of the minimal number of factors necessary for mouse embryonic stem cells (ESCs) to self - renew in culMouse embryonic stem cells stained for key pluripotency markersGRAZIANO MARTELLO Combining computer science algorithms with biological data has enabled researchers to create a model of the minimal number of factors necessary for mouse embryonic stem cells (ESCs) to self - renew in culmouse embryonic stem cells (ESCs) to self - renew in culture.

We have developed a new mouse model harboring a high number of MAIT cells that are also fluorescent by introgressing both a wild mouse gene and a ror (gt) GFP transgene.

A very large number of changes have been discovered in HD model mice and then subsequently observed in human HD patients, suggesting the mice are useful research tools, even if they don't really have Huntington's disease.

The massive number of cells within the OSVZ of humans «tells us we have to be careful when modeling human brain diseases in mice,» says Kriegstein.

Our findings first confirmed previous work with this model in demonstrating that compared to undefeated control animals, mice most susceptible to social defeat stress demonstrated a number of abnormalities in social avoidance, depression and anxiety as measured by routine test procedures.

The current study evaluates how CAG repeat number affects both the age of onset and the progression of disease in the R6 / 2 mouse model of Huntington's disease (Mangiarini et al., 1996) by concurrently evaluating R6 / 2 mice with either 110 or 240 CAG repeats in an F1 hybrid background (C57Bl / 6 x CBA / CaJ).

This new mouse model could be very useful in allowing an initial comparative assessment of the likely potential value of the large number of Zika vaccine candidates being developed around the world.

To sidestep the shortcomings of currently used cancer models, the Salk team harnessed the power of lentiviral vectors to infect nondividing as well as dividing cells and ferry activated oncogenes into a small number of cells in adult, fully immunocompetent mice.

Although the mouse remains the most cost - effective choice for comprehensive phenotyping, the rat remains a better model for a number of human conditions, including cardiovascular disease, diabetes and behavioral disorders.

Despite a large number of sex - specific gametogenesis proteins uncovered in the model organisms Drosophila, C. elegans and mice, no conserved male - or female - specific gametogenic factors common to all lineages of animals have been clearly demonstrated [30]--[33].

However, many E. coli strains that severely infected the mouse models were missing these virulence genes, and some of these strains outcompeted those with high numbers of the genes.

A number of private and public health entities have vaccine candidates and antivirals ready to test, but testing has been delayed without a mouse model.

We recently described retinal regeneration in rd10 mice, which is a model of retinitis pigmentosa, a severe disease that affects a large number of individuals and that results in progressive loss of vision (Sanges et al JCI 2010).

Interestingly, when we looked at the splenocytes in these mice and compared them to controls, we were not able to detect a significant difference in the numbers of Tregs, suggesting that in the transplant model, Tregs may be within the graft - infiltrating population where they could regulate infiltrating host T cells.

«We are actively engaged in the production of a number of knock - in mouse models with genOway.

(2005) Retinal Vessel Volume and Pericyte Number Decrease Over Time in the DBA / 2 Mouse Model of Glaucoma (Investigative Ophthalmology & Visual Science, 46: ARVO E-Abstract 1320).

Administration of NSAIDs in a mouse model causes progressive increase in intestinal permeability, marked increase in gram - negative bacterial numbers, and frank intestinal ulceration.