Not exact matches
The new method, described in the journal
Stem Cells Translational Medicine, could be used to generate large numbers of muscle cells and muscle progenitors directly from human pluripotent stem ce
Stem Cells Translational Medicine, could be used to generate large
numbers of muscle cells and
muscle progenitors directly from human pluripotent
stem ce
stem cells.
«Starting with pluripotent
stem cells that are not
muscle cells, but can become all existing cells in our body, allows us to grow an unlimited
number of myogenic progenitor cells,» said Nenad Bursac, professor
of biomedical engineering at Duke University.
To create different cell types in the lab,
stem cells must be coaxed down the road
of determination — the branching paths that fetal cells normally travel to become neurons, skin cells,
muscle cells, or any
number of other cell types.
In a new study, researchers at Karolinska Institutet have investigated the
number of mutations that accumulate in the
muscle's
stem cells (satellite cells).
A new study by researchers at Karolinska Institutet in Sweden shows how an unexpectedly high
number of mutations in the
stem cells
of muscles impair cell regeneration.
In the future, medical researchers anticipate being able to use technologies derived from
stem cell research to treat cancer, spinal cord injuries, and
muscle damage, amongst a
number of other diseases and impairments.
Although unequal division occurs among
stem cells — allowing one daughter cell to remain a
stem cell while the other matures into another cell type, such as a skin or
muscle cell — the goal
of a normal symmetric cell division is to generate identical daughter cells and increase cell
number.
The decline in skeletal
muscle function associated with human ageing can be ascribed to an increasing
number of mutations in satellite cells — the resident
stem cells
of skeletal
muscle.
In a new study, researchers have investigated the
number of mutations that accumulate in the
muscle's
stem cells (satellite cells).
In the same way, whereas NR supplementation increased
muscle stem cell
number in aged mice, thereby enhancing mitochondrial function and
muscle strength, it reduced the expression
of cell senescence and apoptosis markers [233]; the state
of senescence is important to protect against carcinogenesis [234].