Sentences with phrase «number of risk genes»

Previous studies have identified a number of risk genes responsible for making proteins that are associated with the disease.

However, because of the extremely small effect size of the BD risk (i.e., odds ratio ~ 1.2), Prof. Nakao Iwata says, «a large number of risk genes are still unidentified.

Genetic studies have linked a number of risk genes to autism spectrum disorder (ASD).

This appears to be the case: the greater the number of risk genes a person possessed, the smaller the volume of their hippocampus — regardless of whether they were a high - risk study participant or a patient.

Not exact matches

At last year's Brainstorm Health conference in San Diego, Bergh found himself sitting at dinner with Othman Laraki, the cofounder and CEO of Color Genomics — a company that extracts the DNA from a customer's submitted saliva sample and then looks for a set number of gene mutations known to be associated with increased risk for developing certain hereditary cancers or heart conditions (depending on the test).

7 The number of genes scientists recently linked to insomnia risk.

«Studying congenital heart defects in the «at risk» Down syndrome population can make it possible to reveal genes that impact the risk of heart defects in all children, including those with typical number of chromosomes.»

«This strongly suggests that, though there are hundreds of autism risk genes, the number of underlying biological mechanisms will be far fewer,» he said.

Three simultaneous reports involving more than 32,000 participants uncovered four new diabetes - associated gene variants, bringing to 10 the number of known non-Mendelian genetic risk factors for type 2 diabetes.

The analysis by our unique collaboration indicates that the cancer risk in these relatively benign early lesions is determined by the number of abnormal clones that has been established in the Barrett's mucosa, rather than by specific gene abnormalities.»

«Gene links risk of psychiatric disease to reduced synapse numbers.»

Participating in large international research projects, Dr Harbo and colleagues have helped to identify a number of new risk genes for MS and MG.

«Careful analysis of the total number of repeats, the number of interruptions in the repeat tract, and the methylation status of the FMR1 gene is important for a proper understanding of an individual's risk of transmission of larger alleles to their offspring and to their personal risk of disease pathology.

Previous genetic studies have examined the association of aspirin, NSAIDs, or both with colorectal cancer according to a limited number of candidate genes or pathways.6 - 10 Thus, to comprehensively identify common genetic markers that characterize individuals who may obtain differential benefit from aspirin and NSAIDs, we conducted a discovery - based, genome - wide analysis of gene × environment interactions between regular use of aspirin, NSAIDs, or both and single - nucleotide polymorphisms (SNPs) in relation to risk of colorectal cancer.

As it results in a smaller number of melatonin receptors, the risk variant of the gene can cause weaker natural melatonin signalling, one of the regulatory mechanisms in stabilising the circadian rhythm.

Because you have her whole genome, and not just a test for a single gene, you can potentially look for a vast number of other gene variants that raise the risk of other diseases of adulthood, such as the BRCA1 gene for breast cancer.

However, its extreme length (> 13kb), number of exons (> 50) and high level of alternative splicing means CACNA1C isoform structure and expression is poorly understood, making it difficult to identify which gene isoforms confer disease risk and where they are expressed.

The first reports that gene - editing of bone marrow stem cells in monkeys infected with a variant of simian immunodeficiency virus (SIV) significantly reduces the number of dormant «viral reservoirs» that pose a risk of reactivation.

The alliance will employ Illumina's platform for high - multiplex single - nucleotide polymorphism (SNP) genotyping to develop tests for gene variants deCODE has previously shown to have impact on the risk of a growing number of common diseases with major public health impact.

Next generation sequencing was to include whole exome sequencing (WES) and whole genome sequencing (WGS) and analysis on large numbers of well characterized subjects to identify AD risk and protective gene variants.

Next generation sequencing includes whole exome sequencing (WES) and whole genome sequencing (WGS) and analysis on large numbers of well characterized subjects to identify AD risk and protective gene variants

Linkage and candidate gene studies have been highly successful in the identification of genes that cause the monogenic variants of diabetes and, although progress in the more common forms of T2D has been slow, a number of genes have now been reproducibly associated with T2D risk in multiple studies.

We found mutations in a gene called «POT1» that increased the risk of melanoma in a small number of these families.

Beyond the medical risks to the potential child, a number of long - standing ethical concerns exist regarding the possible practice of germline gene transfer in both human and nonhuman cases.

Fasting has a number of health benefits, including improved cardiovascular health, reduced cancer risk, gene repair, and increased longevity

Fasting, it turns out, has a number of health benefits that most people seek: from improved cardiovascular health and reduced cancer risk, to gene repair and longevity.

«Apo E4, a high - risk gene for Alzheimer's disease, predisposes people to dementia for a number of reasons, including difficulty lowering cholesterol and detoxifying mercury.

A recent study of over 35,000 breast cancer survivors published in the American Cancer Society's journal Cancer found that multi-gene testing can reveal DOUBLE the number of high - risk gene mutations as compared to testing BRCA1 / 2 alone.1

The number of breeding offspring from higher - risk parents should be limited, so that you avoid the possibility of multiplying a defective gene in the breeding population.

In the same way that inbreeding among human populations can increase the frequency of normally rare genes that cause diseases, the selective breeding that created the hundreds of modern dog breeds has put purebred dogs at risk for a large number of health problems, affecting both body and behavior.

It is important to perform the gene test in pedigree Abyssinian and Somali cats that are intended for breeding so that selective breeding can be carried out to gradually reduce the number of carriers and so reduce the risk of affected cats being born.