Sentences with phrase «number of stem cell divisions»

u Christian Tomasetti and Bert Vogelstein, «Variation in Cancer Risk among Tissues Can Be Explained by the Number of Stem Cell Divisions,» Science, Vol.

Analysis linking number of stem cell divisions to different cancer risks suggests most cancer cases can't be prevented

«Is there a limit to the number of stem cell divisions, and does that imply that there's a limit to human life?»

Plotting the total number of stem cell divisions over a lifetime against the lifetime risk of cancer in 31 different organs revealed a correlation.

Tomasetti and Vogelstein conclude that these differences can be explained by the number of stem cell divisions.

As the number of stem cell divisions in a tissue rises, so does the chance of cancer striking that site.

Thus, Tomasetti and Vogelstein reasoned, the tissues that host the greatest number of stem cell divisions are those most vulnerable to cancer.

(A correlation of 1 means that by knowing the variable on the x-axis — in this case, the lifetime number of stem cell divisions — one can predict the y - axis value 100 % of the time.)

Not exact matches

Indeed, although stem cells can divide indefinitely, once they are differentiated, they are locked into a limited life - span, counted down by the number of divisions they undergo.

By plotting the lifetime incidence of various cancers against the estimated number of normal stem cell divisions in the corresponding tissues over a lifetime, they found a strong correlation extending over five orders of magnitude.

Although unequal division occurs among stem cells — allowing one daughter cell to remain a stem cell while the other matures into another cell type, such as a skin or muscle cell — the goal of a normal symmetric cell division is to generate identical daughter cells and increase cell number.

However, stem cells and some cancer cells make enough telomerase to keep their telomeres from shortening, effectively stopping the aging clock and allowing a seemingly unlimited number of cell divisions.

They examined 17 cancer types in 69 countries and found a strong correlation between the number of stem - cell divisions and the incidence of the disease, regardless of the countries» environment or state of economic development.

Importantly, this results in an abnormal increase in centrosome number, a 10-fold reduction in the numbers of satellite stem cells undergoing asymmetric divisions, and a marked decrease in the generation of myogenin - expressing progenitors.

Instead, most stem cell divisions produce offspring fated to develop into neurons, reducing the number of stem cells remaining.

Publishing in Science a group of researchers studied the relationship between the number of normal stem cell divisions and the risk of 17 cancer types in 69 countries.