Sentences with phrase «number of target cells»

As a maximum number of target cells is to contact the array, a fishbone - shaped structure at the top of the channel stirs up the passing liquid.

«If we want to treat the greatest number of diseases, we need to figure out how to get these molecules inside the cells of patients — not just increasing the number of target cells but also hitting tissues other than the liver,» says Anderson, who co-founded a company called CRISPR Therapeutics to pursue those goals.

Not exact matches

Even before treatment, cancer patients in the study had a small number of infection - and tumor - fighting T cells that target these unusual proteins, the researchers found.

«A biological approach to precision medicine targets endless number of diseases: Self - assembling platform effectively delivers inhibitory RNA molecules to targeted cell populations.»

The number of fuel - cell vehicles will likely ramp up steadily in the coming years as automakers work toward reaching a corporate average fuel economy target of 54.5 mpg.

If cells were infected with an influenza A mutant lacking NS1, they proceeded to produce large number of the molecular complexes required for RNAi, which include a protein called Argonaute that slices through the target gene.

Blood testing showed an expansion in the numbers of CD19 - targeted CAR T - cells that coincided with the tumor's regression.

Participants with high - risk bacterial communities, which are commonly found in the population of women studied, also had increased numbers of genital CD4 + T cells — white blood cells that are HIV's primary target.

In an effort to expand the number of cancer gene mutations that can be specifically targeted with personalized therapies, researchers at University of California San Diego School of Medicine and Moores Cancer Center looked for combinations of mutated genes and drugs that together kill cancer cells.

Particularly prominent in the RNA - Seq analysis was the up - regulation of a number of granzymes, a group of proteinases secreted by immune cells that were originally thought to be involved in killing (via apoptosis) virus infected cells or other target cells.

The tool, a vaginal implant, decreases the number of cells that the HIV virus can target in a woman's genital tract.

On the flipside, targeting this growth factor or BCL - 2 could reduce NK cell numbers and offer potential therapies for immune disorders such as some types of autoimmune diseases, sepsis or graft versus host disease, a side effect of bone marrow transplants.

Small numbers of glioma stem - like cells, or GSCs, drive the tumorigenicity of GBM and thus are prime targets for possible treatments.

Such targeting and ease of identification of cancer cells could allow oncologists to spot even tiny numbers of diseased cells in a biopsy sample.

In cases where there are lots of T cells in the vicinity of a tumor, or where tumor cells have undergone large numbers of mutations, which creates additional targets for immune sentries, T cells will signal a full - fledged immune response to the cancer.

Using a new method, the scientists therefore isolated T cells specifically programmed to target the CMV virus from the blood of the donor and transferred small numbers of these cells to the patients.

Once in the lymph nodes, these vaccines can stimulate production of huge numbers of T cells against the vaccine target.

A number of radiotherapies that marry a small but potent amount of radioactive material and a targeted molecular compound have been gaining traction as progressive treatments for malignant NETs, which can develop wherever nerve cells and hormone - producing endocrine cells are present (e.g., gastrointestinal tract, pancreas, lungs, thyroid).

He thinks a number of cancer cell subsets are never really affected by most targeted anticancer drugs currently used.

After they have captured the data at a number of sites they can analyze the data to determine the cell phone or cell phones used by the targeted individual.

Zhao added that this stem cell - targeting approach can provide an alternative to many forms of chemotherapy, which has a number of bad side effects.

«Perhaps we can restore balance by targeting any of a large number of regulatory molecules in the cell.

There are three examples of how law enforcement typically use stingrays for surveillance: First, law enforcement officials may use the cell site simulator with the known cell phone number of a targeted individual in order to determine that individual's location.

In research published today in Cell Reports, the team identify a large number of genes that could serve as potential targets for anti-AML treatments and describe how inhibition of one of these genes, KAT2A, destroys AML cells without harming non-leukaemic blood cells.

The cut - off point for the numbers of the white blood cells targeted by the virus had been 200.

The selection strategy targeted cell populations expressing the inducible endothelial cell adhesion molecules, E-selectin and VCAM - 1, and proved successful in generating microvascular endothelial cell lines from a number of different organs.

«The successful retrieval of memories in AD mice by increasing the number of spines for normal memory processing only in the memory cells, rather than in a broad population of cells, highlights the importance of highly - targeted manipulation of neurons and their circuits for future therapies.

These promised to provide a new therapeutic target for treating obesity, with the researchers finding that they share the fat - burning abilities of brown cells, though they do decrease in number as we approach middle age.

«The successful retrieval of memories in AD mice by increasing the number of spines for normal memory processing only in the memory cells, rather than in a broad population of cells, highlights the importance of highly - targeted manipulation of neurons and their circuits for future therapies,» said Tonegawa in a statement.

Future therapies will have to be based on strategies that act by reducing or increasing the number or activity of specific subtypes of pre - and postsynaptic receptors, transporters, and ion channels, or other membrane molecules at the synapse, and by strategies that exploit the new possibilities offered by stem cell technology and targeted repair.

In the cancer cells, that means huge numbers of mutations that are good targets for immunotherapy.

Once a sufficient number of virus particles have been generated by the packaging cells, they can then be harvested and used to transduce target cells of interest.

Previously, we have described a number of practical considerations that should be taken into account when deciding where to place an FP within a fusion construct [1,2], i.e. positioning of the FP sequence relative to cell compartment targeting sequences, which often have absolute position requirements.

B7x is absent in most human tissues and immune cells, but it is overexpressed on a number of cancers, including stomach cancer, making it a promising target for cancer immunotherapy.

As outlined below, we used a microfluidic quantitative PCR (qPCR) system to elucidate the gene expression profiles of individual human oocytes and small numbers of cumulus cells using a combination of a large number of samples and targets [12], and then extended our studies via the use of parthenogenesis, in conjunction with gene expression profiling, as a functional assay of cytoplasmic maturation of oocytes.

Adoptive Cell Transfer (ACT) is a form of immunotherapy that targets tumors specifically and potently by utilizing large numbers of a patient's own immune cells to target and destroy cancer cells.

Therapy using live cells is increasingly used to replace damaged tissue, deliver gene therapies to target tissues and organs, and stimulate self - healing along with a number of other applications.

In the experiments described in the paper, the MGH team confirmed that their mesothelin - targeting fusion protein binds to mesothelin on either ovarian cancer or mesothelioma cells, activates dendritic cells, and enhances the cells» processing and presentation of several different tumor antigens, inducing a number of T - cell - based immune responses.

December 13, 2011 Molecular markers can predict spread of cancer, guide treatment Molecular markers found in cancer cells that have spread from a primary tumor to a limited number of distant sites can help physicians predict which patients with metastatic cancer will benefit from aggressive, targeted radiation therapy.

So there's a number of things that will target cancer cells because cancer cells love sweets.

The company's antibody - based product candidates target a number of potential indications including AL and AA forms of amyloidosis, Parkinson's disease and other related synucleinopathies and novel cell adhesion targets involved in inflammatory diseases and cancers.

Each level (strand) consists of a number of cells that you will need to rearrange into a target structure using a number of splice moves.

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