Sentences with phrase «number of variants with»

What this means is that the Galaxy S8 will have at least two variants while the S8 + will also have the same number of variants with model numbers SM - G955W, SM - G955U, and SM - G955U1.

Not exact matches

At least in part to deal with such points, Eigen more recently pointed out that each biological genome is not a single sequence of bases on DNA (a unique «point in sequence space») but rather a fairly large number of variant sequences that have quite similar — even indistinguishable — biological functions.11 b, 11 c Most of these functionally similar sequences differ from the «wild - type» sequence in only one or a few locations, but some have fairly large discrepancies.

Across all food product categories, the mean number of nutrients that were correctly identified was significantly higher for both variants of the TL system, compared with both variants of the % DI system (F3, 789 = 9.20, p < 0.001; Figure 3).

You can run an unlimited number of tests with an infinite number of variants; the only limitations are your time and the number of visitors you can test website changes on.

After adjusting for a number of factors — including age, gender, surgery type, baseline cognition, presence of a vascular comorbidity and the presence of a genetic variant that has been associated with an increased risk of Alzheimer's disease — the authors used a three - stage approach to examine the association between inflammatory cytokines and delirium.

But these copy - number variants (CNVs) tend to be extremely rare, showing up in less than 1 % of children with autism.

Anita Thapar of Cardiff University, UK, and colleagues screened DNA from 366 children with ADHD and 1047 without for copy - number variants (CNVs)-- specific regions of DNA that were either missing or duplicated.

They also plan to improve breeding programs by ensuring parental lines have the maximum number of repeats available in a given genotype, and to select for new variants with additional copies that may show superior resistance.

«We would anticipate that over time, a large number of functional variants [of HTR2B] will be identified, with a range of behavioural effects,» says David Goldman at the US National Institute on Alcohol Abuse and Alcoholism in Bethesda, Maryland, and head of the team that carried out the work.

After analyzing both scans together for DNA variants associated with differences between when each patient's movement - associated symptoms first appeared and when they would have been expected based on the number of CAG repeats, MGH CHGR investigator and lead author Jong - Min Lee, PhD, identified two locations on chromosome 15 where variants were significantly associated with either early or late symptom onset.

North Korea reworked Scud technology into a number of variants over the years, apparently with the help of Soviet engineers (many of whom fled the USSR after its 1991 collapse).

The newly identified risk regions nearly double the number that are already known, thereby bringing the number of known common variants associated with breast cancer to around 180.

In contrast, copy number variants turned up in just 2 % of 47 families with multiple cases of apparently inherited autism, the team reports today in Science.

Results from the analysis confirmed previous findings of some copy number variants already associated with autism, but they also found a host of other genes (SHANK2, SYNGAP1, DLGAP2 and the X chromosome — linked DDX53 - PTCHD1 locus) in which mutations seem to be linked to autism.

«One big problem we have is that tens of thousands of human genome variants and phenotypes are spread throughout a number of databases, each one with their own organization and nomenclature that aren't easily accessible,» said Julia Wang, an M.D. / Ph.D. candidate in the Medical Scientist Training Program at Baylor and a McNair Student Scholar in the Bellen lab, as well as first author on the publication.

Many of the variants involved in numerous types of cancer have been identified with genetic sequencing studies of large numbers of patients.

Capra and his colleagues also found that a number of Neanderthal genetic variants influenced the risk for depression, with some variants increasing the risk and others reducing it.

Also, a number of large - scale genomics studies have linked variants of the CPEB4 gene with the impairment of fat metabolism.

Through this study, the researchers almost doubled the number of genetic variants known to be associated with lung health and COPD.

Ehret, a research associate in Chakravarti's lab, crunched the numbers from all the study sites and found variants at 66 sites in the genome — 17 of them newly reported — that had statistically significant associations with blood pressure levels.

With its large sample size, this study had the power to find copy number variants with large effects that occur in more than 0.1 percent of schizophrenia caWith its large sample size, this study had the power to find copy number variants with large effects that occur in more than 0.1 percent of schizophrenia cawith large effects that occur in more than 0.1 percent of schizophrenia cases.

The team found 50 individual variants of DENV - 1 in China, with 20 variants of DENV - 2, and lower numbers of variants of DENV - 3 and DENV - 4.

The number of car models, where at least one variant has a combined city / highway label fuel economy of at least 30 mpg, has grown from 46 models in MY 2012 to more than 70 models in MY 2017, and the number of car models with 40 mpg or higher has more than doubled (comprised of hybrid, electric (EV), plug - in hybrid electric (PHEV), and fuel cell vehicles (FCV)-RRB-.

Through previous studies, many led by our team at the ICR, this brings the total number of genetic variants known to be associated with testicular cancer to 25.

Manou Sommen and colleagues report a study of a targeted resequencing panel for hearing loss was developed including 79 genes for nonsyndromic hearing loss (NSH) L and selected forms of syndromic hearing loss.They established a straightforward variant classification system to deal with the large number of variants encountered and showed that after GJB2, the most commonly mutated genes in a Western - European population are TMC1, MYO15A, and MYO7A.

«This mutation is one of a growing number of deCODE discoveries of relatively low frequency sequence variants with large effect,» said Kari Stefansson, deCODE's CEO and senior author of the study.

In contrast to traditional genetic testing, which usually checks for variants in specific genes, high - throughput sequencing has the potential to reveal a number of secondary findings, i.e., genetic variants with medical relevance but not related to the condition that merited the test.

The first reports that gene - editing of bone marrow stem cells in monkeys infected with a variant of simian immunodeficiency virus (SIV) significantly reduces the number of dormant «viral reservoirs» that pose a risk of reactivation.

A small number of tomcod carried this gene variant before this region of the Hudson River became heavily polluted with PCBs.

The alliance will employ Illumina's platform for high - multiplex single - nucleotide polymorphism (SNP) genotyping to develop tests for gene variants deCODE has previously shown to have impact on the risk of a growing number of common diseases with major public health impact.

For discovery purposes, Whole Exome Sequencing (WES) variant prioritization coupled with clinical and bioinformatics expertise is currently the primary method used to identify novel disease - causing variants, however, causation is often difficult to establish due to the number of plausible variants.

They revealed a number of genes associated with the timing of reproduction, and the genetic variants associated with spring or autumn spawning were found to be largely shared between geographically distant populations.

The first reports that gene - editing of bone marrow stem cells in monkeys infected with a variant of simian immunodeficiency virus (SIV) significantly reduces the number Read more about Gene - editing and vaccines could improve HIV treatment - Scimex

Linkage and candidate gene studies have been highly successful in the identification of genes that cause the monogenic variants of diabetes and, although progress in the more common forms of T2D has been slow, a number of genes have now been reproducibly associated with T2D risk in multiple studies.

They simulated three possible models which had seemed plausible prior to large - scale sequencing, and computed the number of associated low - frequency and rare variants that would be uncovered with their study design.

We could also quantify this contribution, noting that the expected number of sun - related mutations associated with an MC1R variant is comparable to the number gained in about 21 additional years of age.

In tumor samples, where we frequently encounter variants with a very small allele frequency due to contamination with normal tissue, copy number variation, and tumor heterogeneity, high coverage is essential for accurate detection of these variants with high power.

By performing a meta - analysis of rare coding variants in whole - exome sequences from 4,133 schizophrenia cases and 9,274 controls, de novo mutations in 1,077 family trios, and copy number variants from 6,882 cases and 11,255 controls, we show that individuals with schizophrenia carry a significant burden of rare, damaging variants in 3,488 genes previously identified as having a near - complete depletion of loss - of - function variants.

By analyzing genome sequence data from human populations, including 1269 individuals from sub-Saharan Africa, we identify a diverse array of large copy number variants affecting the host invasion receptor genes GYPA and GYPB We find that a nearby association with severe malaria is explained by a complex structural rearrangement involving the loss of GYPB and gain of two GYPB - A hybrid genes, which encode a serologically distinct blood group antigen known as Dantu.

While this calling method will inevitably miss variants in low coverage individuals, the relative numbers of shared alleles with different populations is unbiased.

We determined for each ancient sample the number of rare variants shared with each reference population (Supplementary Note 3).

It depends on the number of genetic variants affecting a trait, their frequencies in the population, the magnitude of their effects and their interactions with each other and the environment.

In the current era of personalized medicine, we have identified a large number of genetic variants in patients with various diseases using next - generation sequencing.

Methods: We did a genome - wide association study of 297 P falciparum isolates from Cambodia to investigate the relationship of 11 630 exonic single - nucleotide polymorphisms (SNPs) and 43 copy number variations (CNVs) with in - vitro piperaquine 50 % inhibitory concentrations (IC ₅₀ s), and tested whether these genetic variants are markers of treatment failure with dihydroartemisinin - piperaquine.

Isotopes are variants of the same chemical element with different atomic weights due to having different numbers of neutrons, such as the most common carbon isotope, carbon - 12, and a heavier stable isotope, carbon - 13.

Once you master the basic push - up, you can up the intensity and the number of muscle fibers trained with this challenging push - up variant.

This February, Marvel will celebrate the return of the Green Goliath with the Hulk Variant Cover Program, showcasing a number of key moments in the Hulk's past life across twenty Marvel titles.

Super Cruise is easy to operate, if you're familiar with ICC and lane - keep assist, or any of a number of variants of such technology from the past half - decade.

Then starts the long process of replacing those seven variants — no doubt with the possibility of that number rising further still.

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