Sentences with phrase «numbers of chromosome copies»

Rather gene dosage, which depends on the number of chromosome copies, is responsible for this: «If the chromosome is multiplied, then more copies of the same gene will be transcribed.

Not exact matches

They made these clones by a process called automatic parthenogenesis: The egg is formed normally (with half the species» usual number of chromosomes), then fertilized by the «polar body,» a cell that is created during oogenesis and contains the same gene copies as the egg, resulting in the shark having half the genetic variation of its mother.

They found that the number of copies of lncRNA genes on a chromosome consistently change in 12 different cancer types and lncRNA genes are widely expressed in cancer cells.

Results from the analysis confirmed previous findings of some copy number variants already associated with autism, but they also found a host of other genes (SHANK2, SYNGAP1, DLGAP2 and the X chromosome — linked DDX53 - PTCHD1 locus) in which mutations seem to be linked to autism.

Venken first sought a vector that could handle large amounts of DNA efficiently, settling on a bacterial artificial chromosome, which was designed a couple years ago and is known to maintain only a few copies of the DNA (though it can produce a high number of copies if it is induced).

As all school - children learn, cells divide using a process called mitosis, which consists of a number of phases during which duplicate copies of the cell's DNA - containing chromosomes are separated into two distinct cells.

As with most cancers, triple - negative breast cancer (TNBC) cells have abnormal amounts of chromosomes or DNA copy number aberrations (CNAs) in their genomes.

Their work, which is published in Nature Ecology and Evolution, shows for the first time the existence in Leishmania of a relation between changes in chromosome copy number and the selection of new alleles important for parasite survival.

If the cells reduce the copy number of this specific chromosome again — say upon another change in environmental conditions — then they turn back into a smooth colony.

For example, part of a description of a method for karyotyping — examining the number and structure of chromosomes in a cell — was not only copied from a paper published by a separate group, but was also not consistent with the procedure actually followed by Obokata's team.

Scientists first reported a link between a surplus of genetic material on chromosome 15 and autism in 1994, a finding that has since been replicated and confirmed to be a copy number variation.

Some research teams over the past five years have used microarray or gene - chip technology to compare genomes and quickly scan them for variations of copy numbers on each chromosome.

Both of the new studies found that copy number events involving either duplication or deletion of the 25 to 30 chromosome - 16 genes — several of which are known to play a role in the developing brain — appear to cause autism.

(Chromosome 16 is the second instance of a copy number variation to be fingered as a causative mutation of the condition.

Her thesis was entitled «Impact of copy number variation on chromatin interactions at the mouse 4qE2 chromosome region.»

This means that it has six copies of each of its seven chromosomes; the complete set numbering 42 chromosomes.

The karyotype of Drosophila comprises only four copies of chromosomes, rendering it a very amenable model to study chromosome number defects.

Use this set of files when interested in identifying CNVs (compared to the reference) in samples that exhibit widespread or long - range divergence from a copy number of two across all autosomal chromosomes.

About 90 % of solid tumors display whole - chromosome aneuploidy, while many tumors with diploid karyotypes nonetheless harbor segmental or arm - length aneuploidies that also result in significant gene copy number alterations.

The resulting DNA copy number variation and patterns of chromosome loss and gain are tumor - type specific, suggesting differential selective pressures on the two tumor cell types.

Mapping the changes in copy number to the phylogeny of these Y chromosomes previously established by the Project identified at least 20 mutational events, and investigation of flanking paralogous sequence variants showed that the mutations involved flanking sequences in 18 of these, and could extend over > 30 kb of DNA.

Changes in chromosome copy numbers were correlated with the corresponding transcript levels, but additional aneuploidy - independent regulation of gene expression was observed.