Sentences with phrase «numbers of diseased cells»

Such targeting and ease of identification of cancer cells could allow oncologists to spot even tiny numbers of diseased cells in a biopsy sample.

Not exact matches

A stronger immune system: Another study found that taking daily cold showers increases the number of disease - fighting white blood cells.

Those chemicals damage cells, promote widespread internal (and invisible) inflammation, and lead to a vast number of health concerns now considered common such as cardiovascular disease and cancer.

Eggplant is loaded with phytonutrients that act as antioxidants that help to reduce the number of free radicals in the body which damage cells and may contribute to certain diseases, including some cancers and heart diseases.

Breastfeeding is contraindicated in infants with classic galactosemia (galactose 1 - phosphate uridyltransferase deficiency) 103; mothers who have active untreated tuberculosis disease or are human T - cell lymphotropic virus type I — or II — positive104, 105; mothers who are receiving diagnostic or therapeutic radioactive isotopes or have had exposure to radioactive materials (for as long as there is radioactivity in the milk) 106 — 108; mothers who are receiving antimetabolites or chemotherapeutic agents or a small number of other medications until they clear the milk109, 110; mothers who are using drugs of abuse («street drugs»); and mothers who have herpes simplex lesions on a breast (infant may feed from other breast if clear of lesions).

«If we want to treat the greatest number of diseases, we need to figure out how to get these molecules inside the cells of patients — not just increasing the number of target cells but also hitting tissues other than the liver,» says Anderson, who co-founded a company called CRISPR Therapeutics to pursue those goals.

Because they can differentiate into almost any cell type in the body, stem cells have the potential to be used to create healthy cells to treat a number of diseases.

Today in Cell and associated journals, 24 research studies from the landmark BLUEPRINT project and IHEC consortia reveal how variation in blood cells» characteristics and numbers can affect a person's risk of developing complex diseases such as heart disease, and autoimmune diseases including rheumatoid arthritis, asthma, celiac disease and type 1 diabetes.

«A biological approach to precision medicine targets endless number of diseases: Self - assembling platform effectively delivers inhibitory RNA molecules to targeted cell populations.»

If this environment is harmed by chemicals, such as through damage to gut cells, it could impact the health of the organisms and would lead to a number of fish diseases but this technique will enable us to increase the tests we can carry out and improve our understanding of how to preserve gut health.»

During the active disease stage of JIA, these cells expand, grow in number, re-circulate through inflamed areas of patients» body, and migrate to the connective tissue of patients» joints.

Mice lacking certain sequences had abnormally low numbers of brain cells that have been implicated in the progression of Alzheimer's disease.

Normal cells contain as many as 35 of these repeats, but sometimes mutation pushes the number of repeats beyond 50, which can lead to symptoms of the disease.

Mice without Del - 1 that had been induced to get EAE also had significantly higher numbers of inflammatory cells in their spinal cords at the disease's peak, a fact that further experiments revealed was due to increased levels of the signaling molecule IL - 17.

«In a large number of diseases, ranging from cancer to ALS, major stress occurs in the affected cells, leading the UPR pathway to be triggered,» he said.

Red blood cell catechol - O - methyltransferase, histamine - N - methyltransferase, and a methanol - forming enzyme were examined in a number of subjects with mental diseases.

They also summarise the outcome of clinical trials that have investigated the use of mesenchymal stem cells in the treatment of a number of inflammatory, degenerative and immune - mediated diseases of cats.

On the flipside, targeting this growth factor or BCL - 2 could reduce NK cell numbers and offer potential therapies for immune disorders such as some types of autoimmune diseases, sepsis or graft versus host disease, a side effect of bone marrow transplants.

The number of extracted tumor cells allows conclusions to be drawn with respect to the success of therapy and the future course of the disease.

Kozai explains, «Dysfunction in glial cells has been implicated as a cause and / or major contributor to an increasing number of neurological and developmental diseases.

But if homologous recombination could be worked out in human (embryonic) stem cells, then cardiomyocytes with mutations in ion channels could be derived, as well as a large number of other very useful disease models of other tissues.

The researchers focused on astrocytes after their initial finding that patients with Alzheimer's disease have unusually high numbers of adenosine receptors in these cells.

A number of new clinical trials aim to take cells from a patient, such as blood cells or immune cells, edit them and transfer them back with new power to undermine diseases like cancer or sickle cell anemia.

In the future, medical researchers anticipate being able to use technologies derived from stem cell research to treat cancer, spinal cord injuries, and muscle damage, amongst a number of other diseases and impairments.

Looking for immune abnormalities throughout the lifespan of the mice, the group found that most immune system components stayed the same in number, but a type of brain - resident immune cells called microglia that are known first responders to infection begin to divide and change early in the disease.

Comparing the magnitude and characteristics of WNV - specific CD4 + T cell response in individuals of similar ages with either neuroinvasive disease or asymptomatic infection, the researchers found that, independent of age, individuals with neuroinvasive disease had higher numbers of WNV - specific CD4 + T cells.

Large numbers of these pileups and double - strand breaks are lethal to the cell, serving as a jumping off point for the development of disease.

«The kidney is a very solid organ, which makes it very difficult to bring enough number of cells upon transplantation,» explains Professor Kenji Osafune, whose lab at the Center for iPS Cell Research and Application (CiRA) at Kyoto University, Japan, is using iPSCs to investigate new treatments for kidney disease.

But if even a small number of mutant mitochondria are retained after the transfer — a common occurrence — they can outcompete healthy mitochondria in a child's cells and potentially cause the disease the therapy was designed to avoid, experiments suggest.

His group showed that a small number of stem - cell like CD8 T cells - called «memory» cells - were enough to produce and repeatedly replenish all of the T - effector cells needed to fight the disease.

A reduction in the number of these cells impairs vascular stability, and leads to cerebral small vessel disease.

«Furthermore, this strategy may be beneficial for other pathological settings in which elevated numbers of regulatory T cells are desirable, such as autoimmune diseases and solid organ transplantation,» Beilhack says.

International and regional organizations collect the numbers of transplants annually by disease, donor type, and stem cell source from countries known to perform HSCT in World Health Organization (WHO) member states.

«Because Th17 cells have been linked to a number of autoimmune diseases, including multiple sclerosis, we thought our compound might inhibit Th17 cells in type 1 diabetes and possibly interfere with disease progression,» said Solt.

The drug, called SelG1, also reduced the frequency of pain crises in people with sickle cell disease and reduced the number of days they spent in the hospital.

The researchers counted the numbers of a particular type of immune cell, known as microglia, in the samples and found that these were more numerous in the brains with Alzheimer's disease.

The deck was stacked in favor of success in the choice of this particular disease since it was known that the therapeutic gene just had to be expressed in a modest number of blood cells to achieve therapeutic benefit.

Research into Stem Cells has grown exponentially over the past two decades and has already yielded successful or promising therapies for a number of diseases.

Finkbeiner's team has already characterized a number of these cell lines for differences between people with the disease and their unaffected family members.

«Since that time, Lorenz has made a significant number of transformative contributions and developed protocols that have fundamentally changed the way we create stem cells in the lab,» said Lennart Mucke, MD, director of the Gladstone Institute of Neurological Disease.

Not so long ago, human embryonic stem cell (hESC) research and SCNT were being hailed as the future of regenerative medicine, capable of generating cures and therapies for any number of diseases and conditions.

They examined 17 cancer types in 69 countries and found a strong correlation between the number of stem - cell divisions and the incidence of the disease, regardless of the countries» environment or state of economic development.

The study was funded by Florida State University; the National Institute of Allergy and Infectious Disease (grant numbers AI119530 and AI111250), the National Institute of Neurological Disorders and Stroke (grant numbers NS048271, NS095348, NS047344, NS051630 and NS079625); and the Maryland Stem Cell Research Fund.

The massive number of cells within the OSVZ of humans «tells us we have to be careful when modeling human brain diseases in mice,» says Kriegstein.

The findings have implications for the design of cancer vaccines and what are called adoptive T cell therapies; when T cells are collected from a patient and grown in the laboratory, increasing in number before they are given back to the patient to help the immune system fight disease.

The question arises nearly every day and it is not surprising given the abundance of articles and advertisements promoting the use of «stem cell treatments» for a staggering number of diseases and injuries.

Stem cell researchers from UCLA used a high resolution technique to examine the genome, or total DNA content, of a pair of human embryonic stem cell lines and found that while both lines could form neurons, the lines had differences in the numbers of certain genes that could control such things as individual traits and disease susceptibility.

Adult stem cell therapy has been shown in a number of clinical trials to slow and, in some cases, even reverse heart deterioration in patients with coronary artery disease (CAD).

Based on positive results produced from a number of scientific clinical trials, coronary artery disease therapy using adult stem cells is a promising new method of treatment for coronary artery disease patients.

These findings will enable increasing numbers of researchers across the world to use these stem - cell like cells to study disease and explore potential regenerative therapies.