Forced aggregation of defined
numbers of human embryonic stem cells into embryoid bodies fosters robust, reproducible hematopoietic differentiation.
Congressional supporters of stem cell research have re-introduced legislation to codify President Barack Obama's 2009 executive order lifting restrictions on
the number of human embryonic stem cell lines available to federally funded researchers.
He has also been an inveterate foe of abortion, a position that informed his repeated votes against expanding
the number of human embryonic stem cell lines available to NIH - funded researchers during the George W. Bush administration.
In the last decade,
the number of human embryonic stem cells (ESC) and human induced pluripotent stem cell (iPSC) lines has dramatically increased.
In April 2004, more than 200 members of the U.S. House of Representatives sent President Bush a letter, asking him to increase
the number of human embryonic stem cell lines that should be eligible for public funding.
In April of 2004, a letter bearing 206 signatures of Members of the United States House of Representatives was sent to President George Bush, asking him to increase
the number of human embryonic stem cell lines that should be eligible for public funding.
Not exact matches
In August
of last year, President Bush approved the use
of federal funds to support research on a limited
number of existing
human embryonic stem cell lines.
He decreed that the case brought by researchers Drs James Sherley and Theresa Deisher, along with a
number of Christian groups including the Christian Medical Association, should be heard; and ordered an injunction temporarily blocking federal funding allocated for
human -
embryonic - stem - cell research.
But a
number of the invited speakers, including Alan Trounson, president
of the California Institute for Regenerative Medicine in San Francisco, and keynote speaker George Daley, a stem - cell scientist at Children's Hospital Boston in Massachusetts, are involved in research using
human embryonic stem cells, which the Catholic Church considers unethical.
But if homologous recombination could be worked out in
human (
embryonic) stem cells, then cardiomyocytes with mutations in ion channels could be derived, as well as a large
number of other very useful disease models
of other tissues.
They used the gene editing technology CRISPR to engineer a series
of human embryonic stem cell lines, which were identical apart from the
number of DNA repeats that occurred at the ends
of their HTT genes.
Earlier this year, scientists at University
of California, Los Angeles, and Advanced Cell Technology
of Marlborough, Massachusetts, reported in The Lancet about the safe and successful use
of RPE cells derived from
human embryonic stem cells, rather than iPS cells, to treat a different type
of AMD in a limited
number of human patients.
In the meantime a large
number of federally funded
human embryonic stem cell projects have been placed on hold, and even more are potentially at risk.
Not so long ago,
human embryonic stem cell (hESC) research and SCNT were being hailed as the future
of regenerative medicine, capable
of generating cures and therapies for any
number of diseases and conditions.
Stem cell researchers from UCLA used a high resolution technique to examine the genome, or total DNA content,
of a pair
of human embryonic stem cell lines and found that while both lines could form neurons, the lines had differences in the
numbers of certain genes that could control such things as individual traits and disease susceptibility.
The use
of human embryonic stem cells, as opposed to patient blood, as the starting material for AST - VAC2 provides a scalable system for the production
of a large
number of vaccine doses in a single lot, reducing manufacturing costs, enabling «off - the - shelf» availability, and ensuring product consistency.
«Basically, this study shows that the genetic makeup
of individual
human embryonic stem cell lines is unique in the
numbers of copies
of certain genes that may control traits and things like disease susceptibility,» said Teitell, who also is an associate professor
of pathology and laboratory medicine and a researcher at UCLA's Jonsson Comprehensive Cancer Center.
A
number of recent articles, however, have reported that hiPSCs are, in fact, notably distinct from
human embryonic stem cells in terms
of their gene expression, epigenetic profile, proliferative capacity and the susceptibility
of their differentiated progeny to cellular senescence and apoptosis [3 — 6].