Prof. De Meyts assures that «Prof. Maruyama makes a convincing case that this [dimerization] model is incorrect, and that in fact,
numerous cell membrane receptors are pre-dimerized in the membrane and are activated allosterically by ligand binding.»
Not exact matches
Sperm racing to fertilize an egg face
numerous hurdles, including burrowing through the zona pellucida, a thick wall surrounding the
cell membrane.
Furthermore, if an agent is able to penetrate one or both of these
membranes, it is often subject to rapid efflux out of the
cell by
numerous broadly acting efflux pumps - rendering the agent ineffective.
From
numerous studies in the Xenopus paired oocyte system and various
cell culture systems, a reasonable assumption might be that if two
cells express the same connexin or innexin and lie in close
membrane apposition, gap junctions will probably be established between them; this assumption has not been investigated rigorously in vivo.