The first study I will be talking about was an intervention trial with two
obese groups of women.
They soared in the lean participants and picked up modestly among those in
the obese group.
Average birth weight was about 100 grams (about 0.2 pounds) heavier in
the obese group.
For fetuses in
the obese group, the average femur length was 0.8 millimeters longer (about 0.03 inches), compared to the non-obese group, and humerus length was about 1.1 millimeters longer (about 0.04 inches), compared to the non-obese group.
The methylation differences between the lean and
obese groups were consistent with those found in a recent study of methylation changes in sperm from fathers who had more than one child with autism spectrum disorder.
When this strain was fed a diet containing 60 kcal % fat, 3 month old rats separated into resistant and
obese groups.
Another randomized clinical trial found an average decrease of around 5 kg over a course of 12 weeks in the non-obese and
obese groups.
Meal frequency did not affect 24 h expenditure, in either
the obese group (2124 ± 312 vs 2142 ± 365 Kcal / day) or lean group (1724 ± 160 vs 1683 ± 166 Kcal / day).
However, the lean group had a two - year delay of disease manifestation and lived two years longer than
the obese group.