Not exact matches
Human females can live a normal life span
with the disease, as can female mice — the latter species also frequently becomes
obese.
When the researchers gave concentrated broccoli sprout extracts to 97
human type 2 diabetes patients in a 12 - week randomized placebo - controlled trial,
obese participants who entered the study
with dysregulated disease demonstrated significantly decreased fasting blood glucose levels compared to controls.
«Our knowledge gained from penguins provides novel insight into the gait mechanics of
humans with increased lateral movements, such as in pregnant women or
obese individuals,» he says.
«Perhaps supplementing the diet of
obese pregnant mothers
with PQQ, which has proven safe in several
human studies, will be a therapeutic target worthy of more study in the battle to reduce the risk of NAFLD in babies,» Jonscher said.
In one recent test, mice implanted
with fecal microbes from thin
humans stayed thin, while mice given bacteria from
obese people gained weight.
The only grave goods
with these Tarxien people (which have been dated by the radiocarbon method to around 2800 B.C.E.) were small, carefully modeled ceramic statuettes of
obese human figures.
To explore the relevance of these results to
humans, the TSRI team worked
with collaborating researchers in Australia to test fat samples from
obese humans and diabetics.
Artifacts from that period — the
obese human and animal figurines and the phallic symbols carved in stone or bone and modeled in clay — point to the idea that the people had an obsession
with the living world and its successful propagation through the descent group or lineage.
Given that adipose tissue (which makes up between 15 and 20 % of the body weight in healthy people) is a source of inflammation in
obese individuals, Christine Bourgeois and Olivier Lambotte, from the University Paris SUD, France, and colleagues, decided to investigate a possible role of the adipose tissue in
humans infected
with HIV and in macaques infected
with simian immunodeficiency virus (SIV, an HIV relative that causes AIDS - like disease in some non-human primates).
For instance,
humans with less PTEN have a very bear - like quality: being exquisitely insulin sensitive even if
obese.
Human brains naturally shrink
with age, but previous research has shown that this seems to happen more quickly in
obese people.
Skeletal muscle tissue also produces increased amounts of iNOS and TNF - α in
obese compared
with lean rodents and
humans (21, 71).
Since most
humans with NASH are
obese and insulin resistant, this represents an important difference in how MCD diets model
human NASH.
To investigate this effect in
humans, Japanese scientists conducted a double - blind trial on
obese adults
with similar body weights and waist measurements in 2009.
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«National Survey data shows that the prevalence of overweight and
obese adults in the U.S. has increased steadily over the past three decades», said Youfa Wang, MD, PhD, lead author of the study and associate professors
with the Bloomberg School's Center for
Human Nutrition.
Altering the gut genome from
obese to lean has «long lasting effects» when combined
with a «healthy diet high in fiber and low in saturated fats,» confirming multiple studies that show «that the food we eat has a direct relationship to the types of bacteria produced in the
human digestive system;»
In
obese humans, substitution of carbohydrate
with protein leads to far greater weight loss, nearly twice as much.
Calorie restriction in
humans is associated
with weight loss, reduced inflammation and improved markers for cardiovascular and metabolic health in
obese -LCB- Formatting Citation -RCB-(9,10) as well as non-
obese (11,12) subjects, proposing a novel therapy for increasing life span.
In rodents, ketogenic diets reduce reactive oxygen species in the brain34 and reduce central inflammation and reactive oxygen species in a model of multiple sclerosis.35 Two clinical papers have found that ketogenic diet feeding of 12 weeks to 6 months reduced signs of liver inflammation in
obese patients
with nonalcoholic fatty liver disease (in addition to improving various other physiological and biochemical variables).36, 37 Unfortunately, basic research into non-alcoholic fatty liver disease has been hampered by species differences between mice and
humans in their hepatic reaction to ketogenic diets.38
Norman RJ, Noakes M, Wu R, Davies MJ, Moran L and Wang JX, Improving reproductive performance in overweight /
obese women
with effective weight management,
Human Reproduction Update, 2004.
Because
humans obtain most of their vitamin D requirement from casual exposure to sunlight, the > 50 % decreased bioavailability of cutaneously synthesized vitamin D3 in the
obese subjects could account for the consistent observation by us and others that obesity is associated
with vitamin D deficiency.
Just as
with humans, cancer cells grow more readily in
obese animals than in lean animals.
Obesity is as significant a health crisis in our companion animals as it is in the
human population,
with over 50 % of dogs and cats in the overweight to
obese range.
Not only is increased bonding time beneficial to
human health, but
with more than 8.5 million
obese or overweight dogs and 14.6 million overweight cats, (according to APPA's 2015 - 2016 National Pet Owners Survey) active outings can be a great start to getting pets in shape as well.
These results concur
with studies on
human patients, which report a decrease in insulin sensitivity of between 44 and 72 % in
obese subjects compared
with normal - weight control subjects (34 — 37).
The rate of progression to absolute insulin deficiency has not been studied in dogs, but epidemiological factors closely match those of
human patients
with the LADA form of type 1 diabetes, who are usually not
obese and tend to be middle aged and older.
I particularly appreciated Foxâ $ ™ s comments about multi-cat households, such as â $ œâ $ ¦ I have found that cats who live only
with humans more often become dull,
obese and sickly than cats whose social environment is enriched by the companionship of other affectionate, playful cats.â $ His words reshaped my view of a multi-cat environment.
With news that more and more pets are joining the growing ranks of the
obese (spurred by too much processed food, sedentary culture and architecture) it's only a matter of time before someone thought of designing a stairlift for these unfortunate animals, just like their
human counterparts.