Sentences with phrase «obese mice»

They showed that in obese mice who had been fed a high - fat diet, tumor progression and dissemination outside the prostate is greater than in mice with normal body weight.

The study shows that a hormone acting on the placenta can protect the offspring of obese mice from being born overweight.

What's more, intestinal bacteria from obese mice increased fat gain more than bacteria from lean mice (1).

In similar lines increased severity of pancreatitis was also observed in diet - induced obese mice when administered with IL - 12 and IL - 18 [37].

Scientists reached this conclusion by transferring microbes from bypass - treated obese mice to a group of lean mice raised in sterile conditions that left them with no intestinal bacteria at all.

In the study, both normal and obese mice completed a 12 - week exercise program.

They've also found that omega - 3s can help fight diabetes in obese mice, pointing the way to potential therapies in humans.

Consistently, killing the intestinal bacteria of obese mice with an antibiotic treatment reduced body fat and improved insulin sensitivity (4, 5).

Since hyper - insulinemia is generally observed in genetically obese mice, the elevation of insulin is most likely the consequence of the obesity rather than the loss of Brs3 function [52].

Studies found that transplanting the gut bacteria of obese mice into lean mice caused the lean mice to gain fat cells quickly.

In the study, the authors identified a monoclonal antibody to aP2 that lowered fasting blood glucose, increased insulin sensitivity, and lowered both fat mass and incidence of fatty liver in obese mouse models.

The news wasn't all bad: When Fischbach's team put obese mice on a diet, their mammary fat tissue had fewer myofibroblasts, suggesting losing weight could make a woman's fat tissue structure more normal and lower her breast cancer risk.

Diet - induced obese mice given these agonists had reduced adiposity, plasma triglycerides, cholesterol, leptin and IL - 6.

The researchers were also able to turn normal - birthweight pups into obese mice by injecting extra leptin 5 to 10 days after birth.

In a later step of this study, microbiota from obese mice fed with a western diet were transferred to the microbiota - free mice.

«This is the first study to show that current strategies to bolster the effectiveness of flu vaccines protected lean mice from serious illness but fell short of protecting obese mice from infections,» said corresponding author Stacey Schultz - Cherry, Ph.D., a member of the St. Jude Department of Infectious Diseases.

Research say that a new enzyme has been shown to offer prevention or a cure for obese mice with diabetes (Photo: Shutterstock)

«Researchers find cancer - fighting drugs help morbidly obese mice lose weight.»

Diet induced obese mice develop peripheral, but not central resistance to leptin».

Obesity researchers made an intriguing discovery in 2001 when they found that large doses of a particular fat - cell protein, adiponectin, caused obese mice to lose weight.

The compound has been making headlines since initial research showed that it helped obese mice live longer, says James Smoliga, Ph.D., one of Baur's coauthors and an associate professor of physiology at High Point University, in High Point, N.C.

When mice are obese and they are allowed to eat as much of they want of a high fat diet, they gained twice as much weight as the non obese mice eating the same high fat diet.

Moreover, leucine supplementation in obese mice increased NAD +, mitochondrial biogenesis, insulin sensitivity, and lipid disposal [107].

The knee cartilage of obese mice who ate the oligofructose supplement was indistinguishable from that of the lean mice.

Findings presented here yesterday at the Society for Neuroscience's annual meeting strengthen the notion that leptin — the subject of a flurry of research since scientists reported 2 years ago that it made obese mice thinner — helps regulate sexual maturity and reproduction.

Research conducted at the University of Barcelona showed that obese mice living on a diet enriched with omega - 3s displayed improved sensitivity to insulin.

In 1994, it was discovered that a protein hormone called leptin, which is released from fat cells and monitored by the brain, was deficient in a certain strain of genetically mutated obese mice.

The researchers gave adiponectin intravenously to obese mice during the last 4 days of their roughly 3 - week - long pregnancies — when the majority of fetal growth occurs.

Back then, Harrison restricted calories for genetically modified obese mice, which remained extremely fat even when food was cut.

«When given to obese mouse mothers during pregnancy and lactation, we found it protected their offspring from developing symptoms of liver fat and damage that leads to NAFLD in early adulthood.»

Maratos - Flier's lab hopes to explore whether obese mice given the hormone will get lean again.

Now, a new study of obese mice reveals that whole - body vibration provides similar metabolic benefits as walking on a treadmill, suggesting it may be useful for treating obesity and type II diabetes.

«Understanding how the drug also enables crosstalk between fat cells and the liver in obese mice allows us to see more of the amlexanox picture — and also sheds light on communication between different tissues in the body.»

But Kahn's team at Beth Israel Medical Deaconess Center found that they could create obese mice that were unusually sensitive to insulin.

Kravitz has a background in studying Parkinson's disease, and when he began conducting obesity research a few years ago, he was struck by similarities in behavior between obese mice and Parkinsonian mice.

«Inactivity in obese mice linked to a decreased motivation to move.»

In addition, administration of a recently discovered adiponectin receptor agonist, AdipoRon, to genetically obese mice led to improved glucose intolerance and longer lifespans.

O'Brien KB, Vogel P, Duan S, Govorkova EA, Webby RJ, McCullers JA, Schultz - Cherry S. Impaired wound healing predisposes obese mice to severe influenza virus infection.

While a common prebiotic supplement did not help the mice shed weight, it completely reversed the other symptoms, making the guts and joints of obese mice indistinguishable from lean mice.

Deficiency of Fc?R1 Increases Body Weight Gain but Improves Glucose Tolerance in Diet - Induced Obese Mice.

In genetically programed insulin - resistant obese mice with increased appetite and reduced physical activity, targeted restoration of Pomc function only within 5 - hydroxytryptamine 2c receptor containing cells induces sex differences in energy balance (267).

Researchers do not yet know why obese mice form more microRNA - 143 than normal mice.

The use of peripherally - restricted inverse agonists in diet - induced obese mice reduces appetite, body weight, hepatic steatosis, and insulin resistance (PubMed: 22841573).

Normal mice had a gene which caused fat cells to secrete leptin, but the mutated obese mice lacked that gene.

Male C57BL / 6J obese mice fed a high - fat diet for 12 weeks and genetically diabetic db / db mice at an age of 6 weeks received dietary C3G supplementation (0.2 %) for 5 weeks.

A new thiazolidinedione, NC - 2100, which is a weak PPAR - γ activator, exhibits potent antidiabetic effects and induces uncoupling protein 1 in white adipose tissue of KKAy obese mice.