Not exact matches
The large amounts of fat around the testes of
obese mice, «could alter the environment
and encourage epigenetic changes», says Teague, who presented the results at the 14th World Congress on
Human Reproduction in Melbourne, Australia, this month.
A common antioxidant found in
human breast milk
and foods like kiwi fruit can protect against nonalcoholic fatty liver disease (NAFLD) in the offspring of
obese mice, according to researchers at the University of Colorado Anschutz Medical Campus.
Based on the observation that
obese mice, rats,
and humans all had elevated serum concentrations of a protein called GDF15 compared to lean controls, Yumei Xiong
and colleagues set out to develop therapies derived from the molecule.
We estimate that the percentage of macrophages in adipose tissue ranges from under 10 % in lean
mice and humans to over 50 % in extremely
obese, leptin - deficient
mice and nearly 40 % in
obese humans.
Both
obese humans and mice have significantly elevated soluble Fabp4 / aP2 levels,
and injection of recombinant Fabp4 / aP2 into lean wild type
mice stimulates hepatic glucose production
and gluconeogenesis.
CD36 -
and GPR120 - mediated Ca2 + signaling in
human taste bud cells mediates differential responses to fatty acids
and is altered in
obese mice.
In rodents, ketogenic diets reduce reactive oxygen species in the brain34
and reduce central inflammation
and reactive oxygen species in a model of multiple sclerosis.35 Two clinical papers have found that ketogenic diet feeding of 12 weeks to 6 months reduced signs of liver inflammation in
obese patients with nonalcoholic fatty liver disease (in addition to improving various other physiological
and biochemical variables).36, 37 Unfortunately, basic research into non-alcoholic fatty liver disease has been hampered by species differences between
mice and humans in their hepatic reaction to ketogenic diets.38
Calorie Restriction - like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism
and Metabolic Profile in
Obese Humans Cell Metabolism 2011 (Nov 2); 14 (5): 612 — 622 ~ FULL TEXT The result of just 30 days on resveratrol were impressive: (1) The same gene regulators (AMPK, SIRT1 and PGC - 1a) were activated in this study as are activated by caloric restriction and resveratrol in mice and endurance training in h
Humans Cell Metabolism 2011 (Nov 2); 14 (5): 612 — 622 ~ FULL TEXT The result of just 30 days on resveratrol were impressive: (1) The same gene regulators (AMPK, SIRT1
and PGC - 1a) were activated in this study as are activated by caloric restriction
and resveratrol in
mice and endurance training in
humanshumans.