Diet - induced
obese mice develop peripheral, but not central, resistance to leptin.
The results of this initial study, and the description of the use of these two diets are presented in the paper by (4) Van Heek et al (1997), «Diet induced
obese mice develop peripheral, but not central resistance to leptin».
Diet induced
obese mice develop peripheral, but not central resistance to leptin».
Not exact matches
Both groups became
obese and
developed a
mouse form of diabetes.
Having an
obese grandfather can make
mice more likely to
develop diabetes and other weight - related disorders, an effect that may be down to sperm epigenetics
«When given to
obese mouse mothers during pregnancy and lactation, we found it protected their offspring from
developing symptoms of liver fat and damage that leads to NAFLD in early adulthood.»
«If human offspring from
obese mothers have a similar risk for
developing fibrosis as we see in
mice, we may be able to predict who is going to
develop more serious disease,» said Thompson.
Based on the observation that
obese mice, rats, and humans all had elevated serum concentrations of a protein called GDF15 compared to lean controls, Yumei Xiong and colleagues set out to
develop therapies derived from the molecule.
One - half of the
mice on the HF diet
developed obesity (diet - induced
obese (DIO)
mice), whereas the remaining
mice were diet resistant (DR).
The
mice given the Nobiletin flavonoid avoided these issues, while those that did not became
obese,
developed type 2 diabetes, and had atherosclerosis and fatty liver issues.
The healthy
mice developed low - grade intestinal inflammation and a metabolic disorder that caused them to eat more, becoming
obese, hyperglycemic, and resistant to insulin.