In a later step of this study, microbiota from
obese mice fed with a western diet were transferred to the microbiota - free mice.
Male C57BL / 6J
obese mice fed a high - fat diet for 12 weeks and genetically diabetic db / db mice at an age of 6 weeks received dietary C3G supplementation (0.2 %) for 5 weeks.
Handa, T., Yamaguchi, K., Sono, Y., and Yazawa, K. Effects of fenugreek seed extract in
obese mice fed a high - fat diet.
Not exact matches
In the study,
mice were given food until they became
obese, and were then
fed the drug, which increases the cellular metabolism of obesity - linked white fat cells.
«Importantly, we found that blocking the actions of the endocannabinoids with pharmacological inhibitors of cannabinoid receptors in the periphery completely normalized food intake and meal patterns in western diet - induced
obese mice to levels found in control lean
mice fed standard chow.»
«When we
feed mice high fat foods, which is like going to McDonalds every day, they become
obese and lose most of their brown fat,» said study lead author Kosaku Shinoda, a postdoc in Kajimura's lab.
«TXN is especially potent in reducing insulin resistance in
mice made
obese by
feeding a high - fat diet,» said Cristobal Miranda, an associate professor at the Linus Pauling Institute who was involved in the research.
MICROBE DIET
Mice fed microbes from
obese people tend to gain fat.
Just 12 weeks of the high fat diet made
mice obese and diabetic, nearly doubling their body fat percentage compared to
mice fed a low fat, healthy diet.
The study found that
feeding obese, pre-diabetic
mice a specialized diet low in the amino acids leucine, isoleucine and valine promoted leanness and improved the regulation of blood sugar.
Over an eight - week period, a control group of
mice fed a high - fat diet predictably became
obese, but the
mice whose Hedgehog pathway had been activated didn't gain any more weight than another control group
fed on a normal diet.
The activation of a protein pathway in fat cells in the
mice allowed the animals to be
fed a high - fat diet without becoming
obese.
The
obese mouse on the right was
fed a high - fat diet.
Studies in diet - induced
obese (DIO)
mice with IRAB - A reduced
fed blood glucose and insulinemia yet impaired glucose tolerance and led to protracted insulinemia during a meal challenge.
In another one of his studies Dr. Panda also observed at how this type of time - restricted eating within eight - hour
feeding windows would relate to
mice that were already
obese.
In experiments
mice fed processed grains put on significantly more weight and became
obese compared to
mice fed whole grains in their natural unprocessed form.
In rodents, ketogenic diets reduce reactive oxygen species in the brain34 and reduce central inflammation and reactive oxygen species in a model of multiple sclerosis.35 Two clinical papers have found that ketogenic diet
feeding of 12 weeks to 6 months reduced signs of liver inflammation in
obese patients with nonalcoholic fatty liver disease (in addition to improving various other physiological and biochemical variables).36, 37 Unfortunately, basic research into non-alcoholic fatty liver disease has been hampered by species differences between
mice and humans in their hepatic reaction to ketogenic diets.38