Sentences with phrase «obese mice increased»

Moreover, leucine supplementation in obese mice increased NAD +, mitochondrial biogenesis, insulin sensitivity, and lipid disposal [107].

Not exact matches

In the study, mice were given food until they became obese, and were then fed the drug, which increases the cellular metabolism of obesity - linked white fat cells.

Mothers who overeat during the period when they are breastfeeding may have children who are at increased risk of becoming obese and going through early puberty, a new study of mice suggests.

In the case of the obese mice, Sinclair observes, resveratrol increased insulin levels while decreasing glucose levels, resulting in healthier liver and heart tissue when compared with obese mice that did not receive treatment.

Cohousing mice harboring an obese twin's microbiota (Ob) with mice containing the lean co-twin's microbiota (Ln) prevented the development of increased body mass and obesity - associated metabolic phenotypes in Ob cage mates.

The U-M study explains how increased cAMP in fat cells promotes the secretion of the hormone interleukin - 6, which signals the liver to stop producing glucose — thus improving overall blood sugar levels in obese diabetic mice.

While hardly any inflammation occurred in the subcutaneous fat of obese mice and cGMP signaling was largely intact, things were very different for the deeper - lying abdominal fat: through the significant weight increase, inflammation had spread and the fat - burning turbocharger cGMP largely came to a standstill.

Mothers who overeat during the period when they are breastfeeding may have children who are at increased risk of becoming obese and going through early puberty, a new study of mice suggests.

Our results indicate that the percentage of macrophages in the adipose tissue that surrounds and infiltrates the extensor digitalis longus muscle is increased in obese mice compared with lean mice.

Adipose tissue within muscle contained significant numbers of F4 / 80 + macrophages, and the percentage of F4 / 80 + cells within this adipose tissue was markedly increased in obese mice compared with lean mice (41 % ± 4 % of macrophages vs. 12 % ± 2 % of macrophages, respectively; P < 0.005, mean ± SD)(Figure 4).

The percentage of F4 / 80 - positive macrophages within this adipose tissue was markedly increased in obese compared with lean mice (e, P < 0.005).

The researchers tested their theory by orally administering a drug that inhibits DNA - PK and found that, in addition to preventing weight gain in the mice, the inhibitor drug boosted mitochondrial content in skeletal muscle, increased aerobic fitness in obese and middle aged mice, and reduced the incidence of obesity and type - 2 diabetes.

In the study, the authors identified a monoclonal antibody to aP2 that lowered fasting blood glucose, increased insulin sensitivity, and lowered both fat mass and incidence of fatty liver in obese mouse models.

Deficiency of Fc?R1 Increases Body Weight Gain but Improves Glucose Tolerance in Diet - Induced Obese Mice.

In genetically programed insulin - resistant obese mice with increased appetite and reduced physical activity, targeted restoration of Pomc function only within 5 - hydroxytryptamine 2c receptor containing cells induces sex differences in energy balance (267).

Meanwhile, Granier became interested in adiponectin receptors after a Japanese group showed that a small molecule could activate the receptors for to increase insulin sensitivity in an obese mouse model.

For some years an asthma drug called amlexanox has been studied for its ability to inhibit TBK1, and a previous experiment showed that when administered to obese mice, it caused weight loss and increased the animals» sensitivity to insulin, helping improve their diabetes and fatty liver disease.

Injection of recombinant leptin into obese homozygotes sharply reduces body weight, decreases food intake, increases energy expenditure, and restores fertility in male mice.

there is a 5-fold increase in number of insulin - secreting cells per islet in obese mice with high insulin secretion

Aside from studies on obese mice, limited research has also shown reduced blood pressure, increased fat burning and increased fatty acid oxidation later in the fast, and increased metabolic rate due to the release of epinephrine and norepinephrine (again, later in the fasting period).

It was shown that the mice with the obese microbiome sample actually extracted MORE calories from the same exact food, gained more weight, and had increased insulin resistance.

Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet - induced obese mice.

Because obesity is known to increase a woman's risk of endometrial cancer by 200 percent, a team of researchers led by oncologist Leena Hilakivi - Clarke of Georgetown Lombardi Comprehensive Cancer Center in Washington, D.C., decided to examine the development of endometrial cancer in obese mice to that in non-obese mice.

Astonishingly, when germ - free mice are colonized with the gut microbiota from genetically obese mice (ob / ob), the otherwise lean mice dramatically increase body weight.

Activity through play is most effective with obese cats as, in addition to burning calories, it increases muscle mass, increases resting metabolic rate, improves mobility and mental stimulation, and often improves the cat — owner bond.10 Owners should be encouraged to increase their cat's activity level at home gradually, based on its needs, starting with 5 to 10 minutes per day of low - intensity activities for sedentary pets (e.g., walking).22 Creativity in activities, such as incorporating food - dispensing toys, placing meals in different parts of the house, and using interactive toys, laser pointers, and electronic mice can also be helpful with a long - term weight loss program.22 Any increase in physical activity is likely beneficial for a cat of any weight.