Normal mice had a gene which caused fat cells to secrete leptin, but the mutated
obese mice lacked that gene.
Not exact matches
Surprisingly, however, the
mice lacking HDAC3 in brown fat did not become
obese.
Gordon and his team found several years ago that genetically
obese mice (the animals
lacked the ability to make leptin, a hormone that limits appetite) had 50 percent fewer Bacteroidetes bacteria and 50 percent more Firmicutes bacteria than normal
mice did.