Sentences with phrase «obese mice reduces»

Not exact matches

Injections of leptin in obese mutant mice cause them to reduce food intake and lose weight (and these injections work even if tiny doses are delivered directly to the hypothalamus).

When tumor cells that no longer express CCR3 are implanted in the prostates of mice, tumor progression and dissemination are significantly reduced, especially in obese mice.

While adjuvants improved the immune response to vaccinations in both lean and obese mice, the overall immune response was reduced in the obese animals compared to their lean counterparts.

Next, they reduced the blood aP2 levels in obese and diabetic mice to low levels seen in lean healthy mice.

But in September, Umut Ozcan, an obesity researcher at Children's Hospital Boston, reported that a key inflammatory protein actually reduces insulin resistance in obese diabetic mice, curing them of diabetes.

β-less mice on a Chow diet had a reduced metabolic rate and were slightly obese.

«TXN is especially potent in reducing insulin resistance in mice made obese by feeding a high - fat diet,» said Cristobal Miranda, an associate professor at the Linus Pauling Institute who was involved in the research.

Treating obese mice with catestatin (CST), a peptide naturally occurring in the body, showed significant improvement in glucose and insulin tolerance and reduced body weight, report University of California San Diego School of Medicine researchers.

This difference may be explained by the reduced levels of normal CST in obese mice compared to the lean control animals.

The researchers tested their theory by orally administering a drug that inhibits DNA - PK and found that, in addition to preventing weight gain in the mice, the inhibitor drug boosted mitochondrial content in skeletal muscle, increased aerobic fitness in obese and middle aged mice, and reduced the incidence of obesity and type - 2 diabetes.

Diet - induced obese mice given these agonists had reduced adiposity, plasma triglycerides, cholesterol, leptin and IL - 6.

In genetically programed insulin - resistant obese mice with increased appetite and reduced physical activity, targeted restoration of Pomc function only within 5 - hydroxytryptamine 2c receptor containing cells induces sex differences in energy balance (267).

(17) Slow - aging growth hormone receptor knockout (GHRKO) mice are obese, but highly insulin sensitive: in such animals, surgical removal of visceral adipose tissue impairs insulin secretion and peripheral insulin action, in part by reducing adiponectin production.

Studies in diet - induced obese (DIO) mice with IRAB - A reduced fed blood glucose and insulinemia yet impaired glucose tolerance and led to protracted insulinemia during a meal challenge.

Injection of recombinant leptin into obese homozygotes sharply reduces body weight, decreases food intake, increases energy expenditure, and restores fertility in male mice.

Aside from studies on obese mice, limited research has also shown reduced blood pressure, increased fat burning and increased fatty acid oxidation later in the fast, and increased metabolic rate due to the release of epinephrine and norepinephrine (again, later in the fasting period).

Consistently, killing the intestinal bacteria of obese mice with an antibiotic treatment reduced body fat and improved insulin sensitivity (4, 5).

Green tea -LRB--)- epigallocatechin -3-gallate reduces body weight with regulation of multiple genes expression in adipose tissue of diet - induced obese mice

Reduced adiposity and improved insulin sensitivity in obese mice with antisense suppression of 4E — BP2 expression.

In rodents, ketogenic diets reduce reactive oxygen species in the brain34 and reduce central inflammation and reactive oxygen species in a model of multiple sclerosis.35 Two clinical papers have found that ketogenic diet feeding of 12 weeks to 6 months reduced signs of liver inflammation in obese patients with nonalcoholic fatty liver disease (in addition to improving various other physiological and biochemical variables).36, 37 Unfortunately, basic research into non-alcoholic fatty liver disease has been hampered by species differences between mice and humans in their hepatic reaction to ketogenic diets.38