Scalfi L, Coltorti A, Contaldo F. Postprandial thermogenesis in lean and
obese subjects after meals supplemented with medium - chain and long - chain triglycerides.
Not exact matches
In this [pioneering] study,
obese patients were
subjected to a variety of performance assessments in a baseline period, then
after 1 and 6 weeks of weight loss via protein - sparing modified fast (1.2 g / kg ideal body weight from lean meat, fish, or fowl; probably around 80 grams of protein / d, 500 - 750 kcal / d).
RESEARCH DESIGN AND METHODS
Subjects (n = 54) were given a high - fat meal (75 g fat, 5 g carbohydrate, 6 g protein)
after an overnight fast (nonobese control [NOC]: age 39.9 ± 11.8 years [mean ± SD], BMI 24.9 ± 3.2 kg / m2, n = 9;
obese: age 43.8 ± 9.5 years, BMI 33.3 ± 2.5 kg / m2, n = 15; impaired glucose tolerance [IGT]: age 41.7 ± 11.3 years, BMI 32.0 ± 4.5 kg / m2, n = 12; type 2 diabetes: age 45.4 ± 10.1 years, BMI 30.3 ± 4.5 kg / m2, n = 18].
After four weeks,
obese subjects lost an average of 400g body fat and their waist circumference decreased by 1.3 cm.
A more formal study that did evaluate the effects of a ketogenic diet confirmed the efficacy of carbohydrate restriction: in a small prospective cohort,
obese subjects began a ketogenic diet
after undergoing a 24 - hour esophageal pH probe test (which measures the pH of the esophagus).
In the most impressive study performed so far, in a cohort of
obese women,
after just 10 weeks on a low - carb diet, in all
subjects with a confirmed GERD diagnosis, «all GERD symptoms and medication usage had resolved in all women» (22).