The constant rise in
obesity and diabetes represents a major burden of our society.
Not exact matches
Obesity is recognized as a leading risk factor for a range of serious diseases, including heart disease, stroke
and diabetes,
and its treatment
represents an area of compelling unmet medical need.
Using genomics approaches, Dr. Nobrega has identified the gene IRX3 as the strongest association to polygenic
obesity in humans,
and characterized the mechanisms by which mutations altering the expression of a gene called TCF7L2 also
represent the strongest genetic link to type 2
diabetes in humans.
Metabolic Syndrome, which includes
obesity and diabetes,
represents a major public health concern, caused by a combination of increased food consumption
and reduced physical activities, with contributions from host genetics, environment
and tissue inflammation.
Obesity (sometimes not even responsive to extreme calorie restriction), osteoarthritis, Anterior Cruciate Rupture,
diabetes, hypothyroidism, prostatic cancer, hemangiosarcoma, osteosarcoma, urinary incontinence, urinary tract infection, juvenile vulva are just a few conditions that are overly
represented in spayed
and neutered pets.