Sentences with phrase «objective response»

Patients whose tumors had a normal BRAF gene showed an overall objective response rate of 61 %.

The biotech specialist said that its updated phase 2 data in a study of its poziotinib candidate treatment for non-small cell lung cancer resulted in a preliminary confirmed objective response rate and potential progression - free survival benefit in patients with the EGFR Exon 20 Mutant form of the disease.

It analyses your responses and screens through the universe of Mutual funds to pick a diversified portfolio just for you to achieve your objectives

You know, as I scroll through these comments I find that there are very few objective responses to the article.

The comprehensive and objective responses reflect the transparent principles at the heart of the independently audited process.

Among patients with NSCLC, antibiotic use 60 days out was significantly associated with worse OS, but not worse objective response or PFS.

With nivolumab monotherapy, the observed objective response rate was 23.3 % in the mucosal melanoma group compared with 40.9 % in the cutaneous melanoma group.

All five responders had a durable complete response, bringing the durable response rate (objective responses lasting at least 24 weeks) to 21.7 %.

In dogs with untreated DLBCL, BDI data will predict objective response (OR) to chemotherapy and progression free survival time (PFST) following chemotherapy; and 2.)

Previously, nivolumab plus ipilimumab had improved progression - free survival (PFS) and objective response rate (ORR) vs ipilimumab alone in the phase II CheckMate 069 and phase III CheckMate 067 trials of treatment - naive patients with advanced melanoma.

At data cutoff with a median follow - up of 52.1 weeks, 100 % of patients in the dose - finding phase and 53 % of patients in the dose - expansion phase had confirmed objective responses.

Dala, I put my view out there for an objective response and you immediately divert the subject.

Beyond that training there is, I believe, an objective response.

That's twice now that the Bears peeps have given quality and objective responses.

Overall, 34 percent of patients showed an objective response, meaning that their tumors shrank by more than 30 percent, and did not re-grow.

Data from these two trials also showed an objective response rate of 72 percent among the 18 patients who met criteria for what was defined as a phase II - eligible population.

«Although still only in an early phase trial, brigatinib is showing an objective response rate in approximately 70 percent of ALK - positive patients post-crizotinib and it's showing about a year of progression - free survival.

The objective response rate (defined as the proportion of complete response and partial responses among all evaluable patients) was also higher with chemotherapy (92/549, 16.8 percent) compared with TKI (39/540, 7.2 percent).

In addition to helping patients live longer, more patients treated with pembrolizumab responded to treatment and for a longer duration than those treated with chemotherapy; the objective response rate — the percentage of patients whose tumours shrank or disappeared — was almost twice as high with pembrolizumab: 21 % compared to 11 % on chemotherapy.

The objective response rate, the primary endpoint for the study, was 16 percent (3 of 19).

«It shows that indoximod is the first such therapy to produce an objective response in glioblastoma, an important milestone in the treatment of this serious condition.»

It has been observed that immunotherapy has the ability to enhance the duration of objective responses and provide extended prolongation of patients» survival [10].

In the pooled analysis, the objective response rate was 11 % for nivolumab and 22 % for nivolumab plus ipilimumab.

The objective response rate for the combination was 23 %; for nivolumab monotherapy, it was 11 %.

The objective response rate was 37.1 % and 60.4 % in the mucosal and cutaneous melanoma groups, respectively, and median progression - free survival was 5.9 months vs 11.7 months.

Although lack of effectiveness in the advanced setting does not preclude efficacy in the adjuvant setting, our retrospective single - center study of advanced mucosal melanoma yielded an objective response rate of only 10 % to alkylator - based cytotoxic therapy, suggesting a general lack of efficacy for chemotherapy in this disease.

A study of this combination showed that trametinib / dabrafenib resulted in an objective response rate of 76 % compared with 54 % in patients treated with the BRAF inhibitor alone.

Patients receiving the combination had an objective response rate of 50 %, compared to 40 % for nivolumab and 14 % for ipilimumab — an increase greater than either drug alone.

Objective response, commonly referred to as OR, denotes either a partial or a complete response based on the criteria outlined in the study.

In early results, of 16 evaluable patients, 9 had objective responses (56.3 %); the disease control rate was 68.8 %.

In this patient set, with a 15.4 - month median follow - up, 82 % of the 108 patients had an objective response and 58 % had a complete response — complete disappearance of their lymphoma.

Interim phase II results [12] of first treatment with electroporation of IL - 12 in 28 patients with advanced melanoma, after 24 weeks of treatment, reported at the American Society of Clinical Oncology 2014 Annual Meeting, revealed a 32.2 % objective response rate (ORR; the primary endpoint), with a CR in 10.7 %.

Of the 16 evaluable patients, 9 achieved an objective response (56.3 %) and the disease control rate was 68.8 %.

The objective response rate to the therapy was 22 %, with a slightly higher response rate (23 % vs 15 %) among those on a weekly dosing schedule than those on an every -3-weeks schedule.