Sentences with phrase «observed at high doses»

Some of the effects were only observed at high doses.

Not exact matches

At a 0.2 - millimolar sucralose dose similar to the concentration found in the blood of people with high consumption of low - calorie sweeteners — equal to four cans of diet soda per day — the researchers said they observed increased expression of genes that are markers of fat production and inflammation.

Philip Laipis of the University of Florida, who has also observed tumors in AAV vector - treated mice, agrees, at least for studies using a similarly high dose of AAV to target liver cells, which are more likely than other cell types to take up the AAV vector.

TIC10 seems to be nontoxic to normal cells or mice even at doses 10 times higher that an observed therapeutic dose, however more research needs to be completed to satisfy FDA requirements prior to initiation of clinical testing.

Embryo - fetal development studies carried out on mice and rats also observed a reduced number of pups per litter, reduced pup weight at birth, and an increased frequency of skeletal «variations» in pups after pregnant females were given high doses of DEP.

Recent research suggests that B12 pills at very high doses without intrinsic factor may work, however we have also observed failures with oral B12 if the intrinsic factor, even when not species specific, is not included.

Some variation in clinical effects can be observed; particularly at very high (> 50W) or very low (< 1 W) power settings using the same J / cm2 dose.