Sentences with phrase «observed in cancer cells»

Recently, however, the phenomenon has also been observed in cancer cells and has even been connected with brain development.

Not exact matches

The increased mitochondrial DNA in the genomes of the cancer cells observed by the UAB team suggests somatic insertion of mitochondrial DNA occurred as the cancer developed.

In November 2010 Japanese researchers announced online in Analytical Chemistry that they had built a chip that simultaneously tests how liver, intestine and breast cancer cells respond to cancer drugs, and in February 2010 scientists publishing in the Proceedings of the National Academy of Sciences USA developed a microscale replica of the human liver that allowed them to observe the entire life cycle of hepatitis C, a virus that is difficult to observe in cultured cellIn November 2010 Japanese researchers announced online in Analytical Chemistry that they had built a chip that simultaneously tests how liver, intestine and breast cancer cells respond to cancer drugs, and in February 2010 scientists publishing in the Proceedings of the National Academy of Sciences USA developed a microscale replica of the human liver that allowed them to observe the entire life cycle of hepatitis C, a virus that is difficult to observe in cultured cellin Analytical Chemistry that they had built a chip that simultaneously tests how liver, intestine and breast cancer cells respond to cancer drugs, and in February 2010 scientists publishing in the Proceedings of the National Academy of Sciences USA developed a microscale replica of the human liver that allowed them to observe the entire life cycle of hepatitis C, a virus that is difficult to observe in cultured cellin February 2010 scientists publishing in the Proceedings of the National Academy of Sciences USA developed a microscale replica of the human liver that allowed them to observe the entire life cycle of hepatitis C, a virus that is difficult to observe in cultured cellin the Proceedings of the National Academy of Sciences USA developed a microscale replica of the human liver that allowed them to observe the entire life cycle of hepatitis C, a virus that is difficult to observe in cultured cellin cultured cells.

In the future, this model will be used to assess whether the clinical heterogeneity observed in breast cancers arises from their different cancer cell of origiIn the future, this model will be used to assess whether the clinical heterogeneity observed in breast cancers arises from their different cancer cell of origiin breast cancers arises from their different cancer cell of origin.

By creating an experimental model of leukemia in mice whose cancer cells were resistant to chemotherapy the team was able to caracterize these cells» metabolic profile and observed certain modifications at the level of the mitochondria.

In addition, when researchers tried to «turn off» the STK17A protein, they observed a reduced rate of cancer cell growth.

The researchers have shown that it is possible to produce chromosome modifications in human cells that are genetically identical to those observed in leukemia and other types of human cancer.

The researchers observed the effect of the synthetically produced molecule, JK - 31, on the growth and proliferation of a model human breast cancer cell line and found that it effectively blocked the protein cyclin - dependent kinase 1 (CDK1), which plays a key part in the process of the division of cancer cells, and therefore inhibited the proliferation of the cells.

The scientists have shown that, in all cancers, a sort of «identity crisis» is observed in cancerous cells: in the organs or tissues in which a tumor develops, genes specific to other tissues or to other stages of the development of the organism express themselves in an aberrant manner.

With a view to clinical studies (tests on humans) it is important to note that the effects on the tumor vasculature were even observed at chloroquine concentrations that had little effect on autophagy in the cancer cells.

This was observed in human ovarian cancer cells grown in culture, and then in mouse models of the disease.

Given their similar profiles, Seyedsayamdost and coworkers hypothesized that TDA might exhibit anticancer properties as well, and indeed observed its strong anticancer activity in a screen against 60 different cancer cell lines.

Abnormal centrosome numbers are commonly observed in human cancers and are thought to be at least in part responsible for the improper distribution of the genetic material that is a hallmark of many cancer cells.

Here, they observed that while estrogen receptor was absent in cancer cells, it was prevalent and in many cases increased in the so - called tumor microenvironment — the area around the tumor that helps it grow.

I also think that the next revolution in science might be new imaging techniques to observe our cells and molecules in real time within the entire body during infections or cancer or even while we watch our favorite movie star on video in our doctor's office.

By using molecular genetic tools to reduce the amount of PC in human lung cancer cells, the team observed decreased cell growth, a compromised ability to form colonies in soft agar (a gelatinous material specifically used to grow bacteria and other cells), and a reduced rate of tumor growth in mice.

In fact, when the researchers inhibited the secreted factor related to the activity of inflammatory cells, they observed a decrease in the proliferation of cancer cellIn fact, when the researchers inhibited the secreted factor related to the activity of inflammatory cells, they observed a decrease in the proliferation of cancer cellin the proliferation of cancer cells.

Reporting their laboratory findings in the journal Aging, the team observed that addition of DPI to a mixed population of cells eliminated the tumour initiating cancer stem cells.

Not only does this let them build up complex tissue components like the mammary gland, but also to experiment with specifically adding in a single cell with a known cancer mutation to different parts of the organoid to observe its effects.

Marcus and former graduate student Jessica Konen, PhD began by observing how a mass of lung cancer cells behaves when embedded in a 3 - D protein gel.

The Nature Communications paper covers lung cancer cells; a similar phenomenon of collective invasion led by distinctive cells has been observed in breast cancer, but different genes and biochemical pathways appear to be important in each system.

But by hierarchical clustering of observed alterations in endocytosis, the researchers identified two distinct cancer phenotype clusters, one marked by mutations in the oncogene KRAS in mesenchymal cells and the other by changes in epithelial cells.

In the same way, observing the migration of cancer cells in a 3 - D environment could unlock information on how cancer grows, finds nutrients, and spreadIn the same way, observing the migration of cancer cells in a 3 - D environment could unlock information on how cancer grows, finds nutrients, and spreadin a 3 - D environment could unlock information on how cancer grows, finds nutrients, and spreads.

For the first time, scientists have directly observed events that lead to the formation of a chromosome abnormality that is often found in cancer cells.

In a letter published in the cancer journal Annals of Oncology, researchers led by Professor Jean - Philippe Spano, head of the medical oncology department at Pitie - Salpetriere Hospital AP - HP in Paris, France, report that while treating an HIV - infected lung cancer patient with the cancer drug nivolumab, they observed a «drastic and persistent decrease» in the reservoirs of cells in the body where the human immunodeficiency virus (HIV) is able to hide away from attack by anti-retroviral therapIn a letter published in the cancer journal Annals of Oncology, researchers led by Professor Jean - Philippe Spano, head of the medical oncology department at Pitie - Salpetriere Hospital AP - HP in Paris, France, report that while treating an HIV - infected lung cancer patient with the cancer drug nivolumab, they observed a «drastic and persistent decrease» in the reservoirs of cells in the body where the human immunodeficiency virus (HIV) is able to hide away from attack by anti-retroviral therapin the cancer journal Annals of Oncology, researchers led by Professor Jean - Philippe Spano, head of the medical oncology department at Pitie - Salpetriere Hospital AP - HP in Paris, France, report that while treating an HIV - infected lung cancer patient with the cancer drug nivolumab, they observed a «drastic and persistent decrease» in the reservoirs of cells in the body where the human immunodeficiency virus (HIV) is able to hide away from attack by anti-retroviral therapin Paris, France, report that while treating an HIV - infected lung cancer patient with the cancer drug nivolumab, they observed a «drastic and persistent decrease» in the reservoirs of cells in the body where the human immunodeficiency virus (HIV) is able to hide away from attack by anti-retroviral therapin the reservoirs of cells in the body where the human immunodeficiency virus (HIV) is able to hide away from attack by anti-retroviral therapin the body where the human immunodeficiency virus (HIV) is able to hide away from attack by anti-retroviral therapy.

The notable differences in fluorescence intensity observed between normal cells and cancer cells, as well as different cancer types, provide important points of differentiation between different cell types and make these probes promising tools for cancer detection and diagnostics.

MUS81 plays an essential role in this killing of cancer cells because nuclear DNA was not cut in cancer cells that lacked the enzyme and no activation of the immune system was observed in these cells.

In addition, the combination of defective epithelial barrier and abnormal epithelial cell extrusion observed in this mouse model may be further exploited to study the role of Alix in canceIn addition, the combination of defective epithelial barrier and abnormal epithelial cell extrusion observed in this mouse model may be further exploited to study the role of Alix in cancein this mouse model may be further exploited to study the role of Alix in cancein cancer.

It was even more surprising to observe that in absence of Sox9, pre-cancerous cells disappear over time, suggesting that we can eliminate oncogene expressing cells before cancer formation» comments Jean - Christophe Larsimont, the first author of this study.

The team then validated this finding, by disrupting the KAT2A gene from leukemia cells in transgenic mice, and observing the effect on the cancer.

Researchers from Heidelberg University and the German Cancer Research Center have succeeded in mapping the intracellular topology by observing proteins in living cells on multiple time and length scales.

Based on empirical data obtained in cases of chronic myeloid leukemia, a myeloproliferative syndrome controlled by the immune system, and in solid tumors, we observe both the possible contribution of innate CD8 (+) T cells to cancer disease control and their susceptibility to tumor immune subversion.

One of the major parameters was the safety of these agents in the respiratory airways and lung parenchyma, since several of these agents are known to cause adverse effects.23 The main adverse effects observed were cough, transient fever and transient decrease in the respiratory functions after the aerosol administration.8, 19, 20 Moreover; it has been observed that excessive deposition of these agents in one site of the respiratory system can induce non-specific side effects in the form of pulmonary edema as observed with many other drugs.16 These side effects were milder when a premedication with bronchodilators and inhaled corticosteroids were administered.8, 19, 20 Until now no long term trial (> 9 months) has been performed since all patients included in previous studies had stage IV non-small cell lung cancer (NSCLC).

Together, our results reinforce the idea that EMT and stem cell factors work cooperatively in highly tumorigenic cancer subpopulations and raise interesting questions about their contribution to the increased metastatic capability observed in the cycling hypoxia - selected subpopulation.

When the gene is mutated or missing, as it is often observed to be in a host of cancers, growth signals affecting cells can get stuck in the «on» position, enabling cells to proliferate out of control.

Schumacher was the first to develop a technology for high - throughput analysis of immune cell reactivity to cancer neoantigens, which has allowed researchers to better observe the effects of immunotherapy in patients and has made it possible to develop personalized, patient - specific immunotherapies.

Differentiation of bCSCs led to an increase in DNA methylation suggesting that the hypomethylated state is characteristic of immature cancer cells, similar to that that observed for normal blood and skin stem cells [3].

However, the exact cytoskeletal strategy that the cell uses to cross the physical BM barrier depends on the physiological context and the physical environment, as observed by examining actin structures in invading cancer and immune cells, and in cells that invade during developmental processes such as angiogenesis and anchor cell invasion in Caenorhabditis elegans.

These allogeneic cells have the potential to participate in immune surveillance for breast or other cancers as observed in clinical hematopoietic stem cell transplantation.

PNBs were also observed on occasion in stromal cells, but their probability was below 20 %, and their size was small compared to the size of cancer - cell generated PNBs.

Earlier reports support the observed hypoxia induced increase in CSC in breast cancer cell lines (18 — 20), but the ER - α — dependent contrasting reaction has not been reported elsewhere.

The changes to cell reprogramming that the scientists observed in the young flies can occur inappropriately in adult human cells — spurring cancer, for example.

With saffron, prevention of rapid cancer cell growth has been observed in cases of pancreatic, lung, colon and breast cancer growth.

As noted in Part I of this article, γ - tocopherol is preferentially metabolized into γ - CEHC, and the latter compound has been observed to exert much stronger anti-proliferative activity than α - CEHC in prostate cancer cells and rhabdomyosarcoma cells.

In a study observing its effects on ovarian cancer cells and cell - mediated responses, Reishi inhibited cell colony formation and cell migration demonstrating its ability to protect already healthy cells.

Genistein Inhibits Both Estrogen and Growth Factor — stimulated Proliferation of Human Breast Cancer Cells Cell Growth & Differentiation 1996 (Oct); 7 (10): 1345 — 1351 Genistein is a naturally occurring dietary protein tyrosine kinase (PTK) inhibitor that is hypothesized to be responsible for the lower rate of breast cancer observed in Asian women consuminCancer Cells Cell Growth & Differentiation 1996 (Oct); 7 (10): 1345 — 1351 Genistein is a naturally occurring dietary protein tyrosine kinase (PTK) inhibitor that is hypothesized to be responsible for the lower rate of breast cancer observed in Asian women consumincancer observed in Asian women consuming soy.

And, though they were skeptical that they would observe any difference in tumor biology in the diet - treated patients with such a short - term dietary intervention, just within those few weeks, they found significantly lower cancer proliferation rates, and significantly higher rates of cancer cell death.

From the study: «In contrast to our previous studies conducted among men with prostate cancer and those with abnormal biopsies that showed high grade prostatic intraepithelial neoplasia or foci of atypical cells (5,6), we did not observe differences in PSA change between the study armIn contrast to our previous studies conducted among men with prostate cancer and those with abnormal biopsies that showed high grade prostatic intraepithelial neoplasia or foci of atypical cells (5,6), we did not observe differences in PSA change between the study armin PSA change between the study arms.

Concern about alkylphenols first surfaced decades ago when a group at Tufts observed an excessive proliferation of human breast cancer cells in certain types of plastic containers, something that would normally only be seen if the cells were exposed to some type of estrogen.

In controlled studies, the catechins in tea leaves have been observed to hinder the development of cancer cells, and are able to prevent free radicals from doing cellular damage that can potentially lead to malignancieIn controlled studies, the catechins in tea leaves have been observed to hinder the development of cancer cells, and are able to prevent free radicals from doing cellular damage that can potentially lead to malignanciein tea leaves have been observed to hinder the development of cancer cells, and are able to prevent free radicals from doing cellular damage that can potentially lead to malignancies.