The report demonstrates phenotypic variability in regard to the presence of
observed microcephaly as well as the degree of brain damage and affected brain structures with congenital ZIKV infection.
Not exact matches
«There is no evidence linking any vaccine to the increases in
microcephaly cases that were
observed first in French Polynesia during the 2013 - 2014 outbreak and more recently in northeastern Brazil,» the WHO said in a statement.
Furthermore, the defects
observed are specific to an infection by ZIKV, as other neurotropical viruses of the flavivirus family (West Nile virus, yellow fever,...) did not cause
microcephaly, in contrast to Zika virus.
«The increased number of newborns with
microcephaly observed during the Zika outbreak in Brazil is linked to Zika infection of the mother during early pregnancy,» explains Drexler.
The findings — so far
observed only in cells and minibrains grown in the lab — offer a possible explanation for the misshapen heads that are the hallmark of
microcephaly, a condition that afflicts some babies infected with Zika.
Contracted through the bite of an infected mosquito or through sexual or other modes of transmission, Zika virus (ZIKV) infection can be prenatally passed from mother to fetus.1 The virus was first identified in the region of the Americas in early 2015, when local transmission was reported in Brazil.2 Six months later, a notable increase in the number of infants with congenital
microcephaly was
observed in northeast Brazil.3, 4 Clinical, epidemiologic, and laboratory evidence led investigators to conclude that intrauterine ZIKV infection was a cause of
microcephaly and serious brain anomalies.5 - 7 However, as with other newly recognized teratogens, these features likely represent a portion of a broader spectrum.